A5012816757- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- DNA Repair Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Carcinogens and Genotoxicity Assessment
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Innovations in Medical Education
- Cancer-related Molecular Pathways
- DNA and Nucleic Acid Chemistry
- T-cell and B-cell Immunology
- Effects and risks of endocrine disrupting chemicals
- Biofield Effects and Biophysics
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Magnetic and Electromagnetic Effects
- Celiac Disease Research and Management
- Immunotherapy and Immune Responses
- Interprofessional Education and Collaboration
- Electrolyte and hormonal disorders
- Electromagnetic Fields and Biological Effects
- Genomic variations and chromosomal abnormalities
- Cancer therapeutics and mechanisms
Jikei University School of Medicine
2012-2025
Kanagawa Rehabilitation Hospital
2016
Tokyo National Hospital
1998-2001
Genesis Research Institute
1995-1997
Aichi Cancer Center
1997
Methylation of CpG sites in the genome, which is generally conserved during cell replication, considered to play important roles differentiation and carcinogenesis. However, investigations on changes methylation status have been limited known genes. To make a genome-wide search for differentially methylated genes, we developed methylation-sensitive–representational difference analysis (MS-RDA) method. The representation genome was prepared using methylation-sensitive restriction enzyme Hpa...
BackgroundThe study aim was, for the first time, to conduct a multicenter randomized controlled trial evaluate effect of tonsillectomy in patients with IgA nephropathy (IgAN).
An early histopathologic predictor of the renal prognosis, before occurrence advanced glomerular sclerosis/interstitial fibrosis and/or apparent dysfunction, remains to be established in IgA nephropathy (IgAN). This study aimed determine whether density (GD; nonsclerotic number per cortical area) biopsy specimens obtained at an stage IgAN could predict long-term outcome.The predictive value factors biopsy, including GD, on outcome was retrospectively analyzed for 98 patients who had with...
The mutational spectra of carcinogenic heterocyclic amines (HCAs), 2-amino-3,4-dimethylimidazo[4,5-b]quinoline (MeIQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-9H-pyrido[2,3-b]indole (A alphaC) were studied in the colon Big Blue mice. In 90, 115 105 lacI mutants from mice fed 300 p.p.m. MeIQ, 400 PhIP 800 A alphaC, respectively, 92, mutations identified. G:C-->T:A transversions predominated with these HCAs. Mutational hot spots for base-substitution caused by alphaC...
Background: The cardio-ankle vascular index (CAVI) is a noninvasive of arterial stiffness that independent blood pressure at the time measurement. Although role CAVI as predictor cardiovascular events has been reported, few studies have considered kidney prognosis. This study investigated association between and long-term prognosis in patients with non-diabetic chronic disease who underwent biopsy. Methods: was longitudinal, observational, single-center stages 1–4 follow-up ≥1 year had...
The micronucleus test is used widely as an in vivo short-term assay for potential carcinogens. In the present study, results of were affected by cobalt dichloride pretreatment. Cobalt was to induce erythropoietin, a growth factor erythropoiesis. increase mutagen-induced response following pretreatment, therefore, may have been due change rate greatest interaction between pretreatment and mutagen treatment induction micronucleated polychromatic erythrocytes (MPCE) occurred when mice injected...
Introduction: There is still insufficient data concerning the clinical effects of eplerenone, a selective aldosterone blocker, in patients with non-diabetic chronic kidney disease (CKD). Methods: This study included CKD urinary protein excretion (UPE) 1.0 g/gCr or more spite long-term treatment renin–angiotensin system (RAS) inhibitors. The eplerenone (25–50 mg/day) were investigated for 12 months. Results: Eplerenone was associated 38% reduction UPE after only slight increase serum...
Glomerular enlargement is an important process that preserves the optimal surface area of glomerular capillaries under both physiological and pathological conditions. However, information limited regarding how size defined, especially in chronic kidney disease (CKD) patients.A total 206 renal biopsy specimens obtained from two different patient cohorts with or without a diagnosis glomerulonephritis (non-GN group IgAN group) were examined. The mean volume was estimated outer capillary...
In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated reduced renal survival. However, the predictors of have not yet been clarified. All who received 6-month from 2004 to 2010 in our four affiliated hospitals and achieved a reduction proteinuria <0.4 g/day 1 year treatment were retrospectively evaluated. The primary outcome was ≥1.0 during follow-up or additional antiproteinuric therapy. Two histological classifications evaluated, Oxford...
Recent studies have revealed the pivotal role of complement activation in pathogenesis antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN). This study investigated clinicopathologic and prognostic significance glomerular C3 deposition renal histopathology patients with ANCA-GN.We retrospectively identified 142 ANCA-GN from 6 hospitals Japan (2004-2020). was defined as staining ≥1+ on a scale 0 to 2+ using direct immunofluorescence (IF). The primary composite end...
Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating development a male. Three different resulting truncation the protein, detected 3 families. They 9474insA (exon 24, termination at codon 3110), C8729A 20, S2834 ter) and 982del4 9, 275). The mutation was family with case male cancer. Age onset young, range 28-43 years, 2 female mutations. One probable missense mutation, A10462G (I3412V), further families,...
<i>Background:</i> There is no clinical classification of immunoglobulin A nephropathy (IgAN) in practice. In this study, we used receiver-operating characteristic (ROC) analysis to create accurate grades based on parameters associated with the development end-stage renal disease (ESRD) IgAN patients. <i>Methods:</i> We performed a retrospective 116 patients IgAN. The association between variables and progression ESRD was examined. <i>Results:</i> Logistic...
The effects of a 4.7 tesla (T) static magnetic field (SMF) on the frequency micronucleated cells (MN-cells) in CHL/IU induced by mitomycin C (MMC) were studied vitro. Exposure to T SMF for 6 hr significantly decreased MMC-induced MN-cells expression culture periods 18, 42, 54 and 66 hr. highest was observed at period 42 gradually same manner both exposed control groups. These results suggest that may exert influence during DNA damage stage produced MMC rather than formation micronuclei...
Abstract 2‐Amino‐3,4‐dimethylimidazo[4,5‐ f ]quinoline (MelQ), a food mutagen, induces forestomach tumors in CDF 1 mice. We established polymerase chain reaction (PCR)–single‐strand conformation polymorphism (SSCP) analysis system to detect mutations the mouse p53 gene exons 2–10, which encompass all five regions conserved among species, and examine loss of heterozygosity (LOH) that uses newly identified polymorphisms between BALB/c DBA mice, parental strains Four original (one papilloma,...
This study aimed to identify training needs among primary care physicians in Japan who had no formal training. We conducted a focus group interview with seven Japanese not previously undergone specialist and been recruited family medicine program that used problem-based learning approach. At the start of program, attended interview. The discussion was recorded, transcribed analyzed using Steps for Coding Theorization method. Three main themes emerged. First, there is lack standard...
This report describes a pair of identical twins with IgA nephropathy (IgAN). One them showed diffuse mesangial proliferation crescent formations in the glomeruli, moderate proteinuria and required intensive therapies including corticosteroids for remission. In contrast, other had only focal alterations exhibited subtle level urinary abnormalities throughout follow-up without steroid therapy. Although our monozygotic have completely genotypes, clinicopathological features their IgAN were...