A5101912846- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Heart Failure Treatment and Management
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Hemodynamic Monitoring and Therapy
- Diet, Metabolism, and Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Pesticide and Herbicide Environmental Studies
- Orthopaedic implants and arthroplasty
- Fibroblast Growth Factor Research
- Parathyroid Disorders and Treatments
- Inflammasome and immune disorders
- Berberine and alkaloids research
- Nerve injury and regeneration
- Metastasis and carcinoma case studies
- Synthesis and biological activity
- Sulfur Compounds in Biology
- Synthesis of heterocyclic compounds
- Cardiac Valve Diseases and Treatments
- Hydrogen's biological and therapeutic effects
- Cannabis and Cannabinoid Research
- Endoplasmic Reticulum Stress and Disease
Nanjing Tech University
2024
Guangdong Medical College
2023
Macau University of Science and Technology
2021-2023
Guizhou University
2023
Air Force Medical University
2009-2022
Fudan University
2022
Henan Provincial People's Hospital
2021
Tang Du Hospital
2019-2020
Thomas Jefferson University
2016-2019
GlaxoSmithKline (China)
2018
SERPINA1/AAT/α-1-antitrypsin (serpin family A member 1) deficiency (SERPINA1/ AAT-D) is an autosomal recessive disorder characterized by the retention of misfolded SERPINA1/AAT in endoplasmic reticulum (ER) hepatocytes and a significant reduction serum level. The Z variant SERPINA1/AAT, containing Glu342Lys (E342K) mutation (SERPINA1E342K/ATZ), most common form SERPINA1/AAT-D, prone to misfolding polymerization, which retains it ER leads liver injury. Both proteasome macroautophagy/autophagy...
Closely associated with type 2 diabetes mellitus (T2DM), hepatic steatosis and cardiac hypertrophy resulting from chronic excess intake can exacerbate insulin resistance (IR). The current study aims to investigate the pharmacological effects of hirsutine, one indole alkaloid isolated Uncaria rhynchophylla, on improving IR, elucidate underlying mechanism. T2DM IR in vivo were established by high-fat diet (HFD) feeding for 3 months C57BL/6 J mice. In vitro models induced high-glucose...
CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurological abnormalities in the central nervous system (CNS). Herein, we describe discovery of novel 1-cyclopentenyl-3-phenylurea series potent and CNS penetrant antagonists. Extensive SAR studies, wherein molecules' property forecast index (PFI) was carefully optimized overall balanced developability profiles, led to advanced lead compound 68 with desirable PFI. Compound demonstrated good...
Abstract It remains disputable about perioperative use of renin-angiotensin system inhibitors (RASi) and their outcome effects. This multicenter retrospective cohort study examines association between RASi outcomes in patients undergoing coronary artery bypass graft and/or valve surgery. After the exclusion, are divided into 2 groups with or without preoperative (PreRASi, n = 8581), postoperative (PostRASi, 8130). With using propensity scores matching to reduce treatment selection bias,...
Ulinastatin exerts protective effects against lipopolysaccharide (LPS)-induced cardiac dysfunction. Autophagy has been demonstrated to serve an important role in sepsis-induced cardiomyopathy; however, whether ulinastatin anti-autophagic effect sepsis requires further investigation. The present study aimed determine the of on dysfunction and its autophagy during sepsis. C57BL/6J mice were randomly divided into a control, LPS + group, survival status was observed every 6 h rate at each time...
Hydrogen sulfide (H2S) is a gasotransmitter with important physiological effects, including anti-inflammatory properties, regulation of oxidative stress, vasodilation, etc. Functional therapy involves using treatments that target the underlying cause disease, rather than simply treating symptoms. Epigenetics refer to changes in gene expression occur through modifications DNA, proteins package or non-coding RNA mechanisms. Recent research suggests H2S may play role epigenetic by altering DNA...
Abstract This study aimed to examine association between perioperative uses of aspirin and long-term survival in patients undergoing CABG. A retrospective cohort was performed 9,584 consecutive receiving cardiac surgery from three tertiary hospitals. Of all the patients, 4,132 CABG met inclusion criteria were divided into four groups: with or without preoperative postoperative respectively. 30-day mortality compared use propensity scores inverse probability weighting adjustment reduce...
Our study investigated the effects of terbuthylazine (TBA) and metribuzin (MT) on rice radish at field application concentrations. Both herbicides induced oxidative stress severely inhibited growth in two crops. However, cultivar T-33 exhibited significantly lower levels compared to sensitive S-24, suggesting its higher tolerance TBA MT. To explore potential role metabolism this tolerance, we developed a novel HPLC-Q-TOF-MS method, which demonstrated excellent performance identified 18 20 MT...
article: Application of rapid rehabilitation surgical concept in perioperative nursing patients undergoing single-port thoracoscopic lobectomy - Minerva Medica 2022 December;113(6):1055-6 Journals
Objective: The aim of this study was to the association perioperative administration renin angiotensin system inhibitors (RASi) and clinical outcomes patients with heart failure (HF) undergoing cardiac surgery. Summary Background Data: It is controversial whether RASi should be administered in HF Methods: A total 2338 CABG and/or valve surgeries at multiple hospitals from 2001 2015 were identified STS database. After adjustment using propensity score instrumental variable, logistic...
Background: Continuing or stopping aspirin prior to coronary artery bypass graft (CABG) surgery remains controversial with a major concern of risk bleeding, but some studies have shown that did not increase the bleeding and may be beneficial continued until time after surgery. Hypothesis: The preoperative could short- long-term effects on patients CABG valve Methods: Consecutive (9584) cardiac from Thomas Jefferson University hospital, Abington Memorial hospital UC Davis Medical Center...