A5090892013- Acute Ischemic Stroke Management
- Neurological and metabolic disorders
- Electrolyte and hormonal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Lysosomal Storage Disorders Research
- Renal function and acid-base balance
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Parkinson's Disease Mechanisms and Treatments
- Alkaline Phosphatase Research Studies
- Metabolism and Genetic Disorders
- Biochemical Acid Research Studies
- Ion Transport and Channel Regulation
- Transplantation: Methods and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetic Foot Ulcer Assessment and Management
- Metabolism, Diabetes, and Cancer
Erasmus University Rotterdam
2006-2024
Erasmus MC
2009-2024
Ikazia Ziekenhuis
2009-2018
Amsterdam UMC Location University of Amsterdam
2017
Maastricht University
2017
University Medical Center Utrecht
2017
Medisch Spectrum Twente
2017
Medisch Centrum Haaglanden
2017
Low serum sodium may be associated with cognitive impairment and dementia in the general population, but data remain inconclusive. Therefore, we aimed to determine association of low function incident population.Participants from a prospective population-based cohort were eligible if on (collected between 1997 2008), prevalence incidence available (follow-up until 2018). Global was assessed Mini-Mental State Examination (MMSE) factor (G-factor, derived principal component analysis individual...
Hyperglycemia on admission is common after ischemic stroke. It associated with unfavorable outcome treatment intravenous thrombolysis and intra-arterial treatment. Whether hyperglycemia influences the effect of reperfusion unknown. We assessed whether increased serum glucose modifies in patients acute stroke.We used data from MR CLEAN (Multicenter Randomized Clinical Trial Endovascular Treatment for Acute Ischemic Stroke Netherlands). was defined as >7.8 mmol/L. The primary measure adjusted...
Background Diagnostic errors have been attributed to reasoning flaws caused by cognitive biases. While experiments shown bias cause errors, physicians of similar expertise differed in susceptibility bias. Resisting is often said depend on engaging analytical reasoning, disregarding the influence knowledge. We examined role knowledge and mode, indicated diagnosis time confidence, as predictors anchoring Anchoring occurs when stick an incorrect triggered early salient distracting features...
Background: Angiotensin-converting enzyme inhibitors have shown antiproteinuric effects in normotensive and hypertensive diabetic patients. Angiotensin-receptor antagonists reduce urinary albumin excretion the risk for renal cardiovascular complications patients with type 2 diabetes mellitus. The effect of angiotensin-receptor microalbuminuria has not yet been reported. Objective: To assess losartan microalbuminuria. Design: Multicenter randomized, double-blind, placebo-controlled clinical...
Patients with a transient ischemic attack (TIA) or stroke and prediabetes newly diagnosed diabetes are at high risk of recurrent cardiovascular events. This underlines the importance accurate screening for impaired glucose metabolism in clinical practice. Fasting plasma levels currently most commonly measured glycemic parameter to detect diabetes, even if 2-hour postload glycosylated hemoglobin can be used as well. We assessed prevalence different methods, including fasting glucose,...
Hyperglycemia is common in acute ischemic stroke and associated with larger infarct volume unfavorable functional outcome, also patients who undergo reperfusion therapy. during may be a therapeutic target. However, previous randomized trials on the effect of glucose lowering phase failed to demonstrate effects clinical outcome. Inaccurate measurements not focussing therapy are possible explanations. Our aim was study feasibility accuracy continuous monitoring (CGM) undergoing endovascular...
Newly diagnosed disturbed glucose metabolism is highly prevalent in patients with stroke. Limited data are available on their prognostic value outcome after We aimed to assess the association of prediabetic and diabetic range unfavourable short-term stroke.We included 839 consecutive ischemic stroke 168 intracerebral haemorrhage. In all nondiabetic patients, fasting levels were determined day 2-4. Prediabetic was defined as 5.6-6.9 mmol/L, ≥7.0 pre-existent diabetes use anti-diabetic...
ABSTRACT Objective To evaluate the association between different pre‐eclampsia (PE) phenotypes and development of metabolic syndrome postpartum, in order to identify subgroup formerly pre‐eclamptic women with a worse cardiovascular risk profile requiring tailored postpartum follow‐up. Methods This was cohort study 1102 whom cardiometabolic evaluation performed at least 3 months postpartum. Women were divided into four subgroups based on PE resulting delivery before 34 weeks (early‐onset...
Abstract Objective Current guidelines recommend treating symptomatic hyponatremia with rapid bolus-wise infusion of fixed volumes hypertonic saline regardless body weight. We hypothesize that this approach is associated overcorrection and undercorrection in patients low high Design Single-center, retrospective cohort study. Methods Data were collected on treated ≥1 bolus 100 or 150 mL 3% NaCl for between 2017 2021. Outcomes (plasma sodium rise > 10 mmol/L/24 h, 18 mmol/L/48 relowering...
Oral urea is being used more commonly to treat hyponatremia, but factors contributing the correction rate are unknown. We hypothesized that clinically relevant can be identified help guide hyponatremia with oral urea.
Microalbuminuria is associated with cardiovascular complications and all-cause mortality in patients diabetes (1–3). Inhibitors of the renin-angiotensin system (RAS) protect renal cardiac function these patients, at least partly independent blood pressure reduction (4–9). Recently, a few studies showed that albuminuria hypertensive diabetic reduces risk subsequent events (10–12). The question remains whether this explained by high pressure. No data are available for normotensive patients....
Background and purpose We aimed to assess the safety, feasibility, effects on glucose metabolism of treatment with metformin in patients TIA or minor ischemic stroke impaired tolerance. Methods performed a multicenter, randomized, controlled, open-label phase II trial blinded outcome assessment. Patients previous six months tolerance (2-hour post-load levels 7.8–11.0 mmol/l) were randomized metformin, daily dose 2 g, no for three months. Primary measures safety feasibility adjusted...
The excess risk of macrovascular disease and death associated with diabetes seems higher in women than men. pathogenesis for this difference has not been fully elucidated. We investigated whether female sex was death, independently known factors related to type 2 diabetes, nephropathy, or retinopathy normotensive patients microalbuminuria.We conducted a prospective, prolonged follow-up study subgroup 67 diabetic (46 men 21 women) without established cardiovascular who participated larger...
Impaired glucose tolerance is present in one third of patients with a TIA or ischemic stroke and associated two-fold risk recurrent stroke. Metformin improves tolerance, but often leads to side effects. The aim this study explore the feasibility, safety, effects on metabolism metformin sitagliptin minor impaired tolerance. We will also assess whether slow increase dose better support information treatment reduce incidence these patients. sitAgliptin impAired recent Stroke trial (MAAS trial)...