A5044596624- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Polyomavirus and related diseases
- Pediatric Urology and Nephrology Studies
- Organ Donation and Transplantation
- Complement system in diseases
- Renal and related cancers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Transplantation Outcomes and Treatments
- Cell Adhesion Molecules Research
- IgG4-Related and Inflammatory Diseases
- Nephrotoxicity and Medicinal Plants
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Tumors and Oncological Cases
- Ocular Oncology and Treatments
- Pregnancy and Medication Impact
- Connective tissue disorders research
- Testicular diseases and treatments
- Cutaneous Melanoma Detection and Management
- Inflammatory Bowel Disease
- Diabetes and associated disorders
- Infectious Disease Case Reports and Treatments
- Soft tissue tumor case studies
- Urticaria and Related Conditions
Mayo Clinic in Arizona
2023
University of Minnesota
2016-2021
Twin Cities Orthopedics
2021
New York Proton Center
2019
Children's Medical Center
2014
Parkland Health & Hospital System
2014
The University of Texas Southwestern Medical Center
2014
Background and objectives Immune checkpoint inhibitors are increasingly used to treat various malignancies, but their application in patients with kidney transplants is complicated by high allograft rejection rates. inhibitor–associated a novel, poorly understood entity demonstrating overlapping histopathologic features immune acute interstitial nephritis, which poses challenge for diagnosis clinical management. We sought improve the understanding of these entities through biopsy-based gene...
Focal segmental glomerulosclerosis (FSGS) is a histopathologically defined kidney lesion. FSGS can be observed with various underlying causes, including highly penetrant monogenic renal disease. We recently identified pathogenic variants of UMOD, gene encoding the tubular protein uromodulin, in 8 families suspected glomerular disease.To validate we reviewed clinical and pathology reports members to have UMOD. Clinical, laboratory, pathologic data were collected, genetic confirmation for UMOD...
Alport syndrome (AS) is a hereditary nephritis caused by mutations in COL4A3, COL4A4, and COL4A5, which encode the collagen IV alpha3, alpha4, alpha5 chains, respectively.1 The alpha345 molecule major component of mature glomerular basement membrane kidney.2 Disease-causing these genes may affect synthesis, assembly, deposition and/or function molecule.1 Phenotypically, disease characterized hematuria proteinuria, progressing to end-stage renal disease.
Abstract Background Fibronectin glomerulopathy is a rare genetic nephropathy with only few cases of post-transplant recurrence being reported previously. We highlight case that was initially misdiagnosed and emphasize the importance full immunofluorescence electron microscopy evaluation in allograft biopsies. Case presentation A 36-year-old male history end-stage kidney disease secondary to biopsy-proven type 1 membranoproliferative glomerulonephritis (MPGN) status-post living unrelated...
Some renal biopsies cannot distinguish minimal change disease (MCD) from primary focal segmental glomerulosclerosis (FSGS) because of inadequate sampling and/or a lack sampled glomeruli with sclerosis. As protein excretion in MCD has been described as being albumin-selective, we examined whether the ratio immunoglobulin G (IgG)/albumin staining reabsorption droplets (tPRD) might help FSGS.Frozen tissue 144 native patients nephrotic syndrome and diagnosis or FSGS [73 MCD, 30 tip variant...
Abstract MEST of the kidney are a benign group tumors with very rare incidence malignant transformation. First described in 1998, this tumor has never been reported transplanted organ before. We present unique case de novo donor 4 years after transplant into pediatric patient. Although removal lesions is curative without risking transformation, case, surgical was not attempted to prevent reduction longevity. In report kidney, we describe patient/transplant outcomes resection.
Kidney injury associated with use of immune checkpoint inhibitors that target the programmed death-1 molecule commonly manifests as acute tubulointerstitial nephritis on kidney biopsy. We present a case 66-year-old man who developed at 6 months after initiation treatment anti-programmed antibody, nivolumab, for metastatic urothelial carcinoma. A renal biopsy showed focal moderate-to-severe lymphocytic tubulitis minimal interstitial inflammation. Programmed death ligand-1 immunopositivity was...
We describe a case of acute leukemia ambiguous lineage with novel cytogenetic abnormality. A 1-year-old boy presented abnormal complete blood count findings, and was found to have blasts mild dysgranulopoiesis. The showed immunophenotypic evidence myeloid T-lineage differentiation. Subsequent analysis r(2)(p25q31) as the sole stem line defect clonal evolution. While abnormalities can critical role in classification prognostication lymphoblastic leukemia, significance remains unclear. This...
Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN). Furthermore, immunostaining KM55, an antibody identifies Gd-IgA1, may be helpful to differentiate IgAN HSPN from secondary causes glomerular deposition. We report sequential kidney biopsies malignancy-associated HSPN, showing intense mesangial deposition at initial biopsy dramatic decrease disappearance deposits after...