A5045286764- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Cardiovascular Health and Risk Factors
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Pharmacogenetics and Drug Metabolism
- Circular RNAs in diseases
- Vitamin D Research Studies
- Traditional Chinese Medicine Studies
- Extracellular vesicles in disease
- Diabetes Management and Education
- Artificial Intelligence in Healthcare
- Diet, Metabolism, and Disease
- Neurological Disease Mechanisms and Treatments
- Hepatitis C virus research
University of Oklahoma Health Sciences Center
2018-2022
Oklahoma City University
2019-2020
Dyslipidemia is a well-established risk factor for cardiovascular diseases. Although, advances in genome-wide technologies have enabled the discovery of hundreds genes associated with blood lipid phenotypes, most heritability remains unexplained. Here we performed targeted resequencing 13 bona fide candidate dyslipidemia to identify underlying biological functions. We sequenced 940 Sikh subjects extreme serum levels hypertriglyceridemia (HTG) and 2,355 were used replication studies; all...
Diversity in drug response is attributed to both genetic and non-genetic factors. However, there paucity of pharmacogenetics information across ethnically genetically diverse populations India. Here, we have analyzed 21 SNPs from 12 pharmacogenomics genes Punjabi Sikhs Indian origin (N = 1,616), as part the Sikh Diabetes Study (SDS). We compared allele frequency poor metabolism (PM) phenotype among other major global Exome Aggregation Consortium 1000 Genomes. The PM CYP1A2*1 F for slow...
To assess the burden of type 2 diabetes (T2D) and its genetic profile in endogamous populations India given paucity data, we aimed to determine prevalence T2D estimate heritability using family-based cohorts from three distinct Endogamous Ethnic Groups (EEGs) representing Northern (Rajasthan [Agarwals: AG]) Southern (Tamil Nadu [Chettiars: CH] Andhra Pradesh [Reddys: RE]) states India. For comparison, data collected previously another North Indian Punjabi Sikh (SI) EEG was used. In addition,...
Abstract Dyslipidemia is a well-established risk factor for cardiovascular diseases. Although, advances in genome-wide technologies have enabled the discovery of hundreds genes associated with blood lipid phenotypes, most heritability remains unexplained. Here we performed targeted resequencing 13 bona fide candidate dyslipidemia to identify underlying biological functions. We sequenced 940 Sikh subjects extreme serum levels hypertriglyceridemia (HTG) and 2,355 were used replication studies;...
To address the public health issue of type 2 diabetes (T2D) and its genetic profile in India, we aimed to evaluate determinants T2D using family-based cohorts from four distinct Endogamous Ethnic Groups (EEGs) representing two Northern (Punjab [Sikhs: SI] Rajasthan [Agarwals: AG]) Southern (Tamil Nadu [Chettiars: CH] Andhra Pradesh [Reddys: RE]) states examine whether variants found through targeted sequencing previously established 8 South Asian risk loci (including one Sikh population) are...
Higher education levels are known to be associated with better understanding and awareness of type 2 diabetes (T2D) its complications. Given the diverse ethnic socio-cultural characteristics Indian populations, we aimed study effect educational status on fasting glucose (FG) HbA1c from three distinct Endogamous Ethnic Groups (EEGs) in India, which part INDIGENIUS consortium, supported by an Indo-U.S. Collaborative Research Partnership T2D. We obtained data 1,548 individuals 68 families (Mean...
Background: Acute ischemic stroke (AIS) is the fifth leading cause of death in United States. Although early diagnosis difficult, no reliable biomarker that categorizes currently available. Metabolome profiling a useful method to identify such biomarkers. Correlation these biomarkers objective imaging data as infarct volume can better delineate pathophysiology and prognosis. Hypothesis: Disturbances serum metabolites AIS correlate with volume. Methods: We conducted prospective pilot study 20...
Introduction: Diversity in drug response related to cardiovascular and other diseases is attributed both genetic non-genetic factors. However, there a paucity of information across ethnically genetically diverse populations. Here, we have analyzed 20 SNPs from 12 pharmacogenomics genes Punjabi Sikhs Asian Indian origin (N= 1,616), as part the Sikh Diabetes Study (SDS)/Asian Diabetic Heart (AIDHS). Methods: Samples were genotyped using Human 660W Quad Bead Chip panel (Illumina, Valencia, CA)....
Background: Despite recent advances in treatment, early diagnosis and prognosis of acute ischemic stroke (AIS) suffers from significant limitations. Growing number mostly case-control studies have determined that noncoding, micro-ribonucleic acid (miRNAs) play a role the pathophysiologic processes related to cerebral ischemia post-stroke recovery. This pilot project is longitudinal study, which investigates difference miRNA regulation vs. chronic stage stroke. Hypothesis: Expression some...