A5061783240- Gun Ownership and Violence Research
- Immune Response and Inflammation
- Injury Epidemiology and Prevention
- Suicide and Self-Harm Studies
- Pancreatic and Hepatic Oncology Research
- Innovations in Medical Education
- Cardiac electrophysiology and arrhythmias
- Palliative Care and End-of-Life Issues
- Cardiac Fibrosis and Remodeling
- Diversity and Career in Medicine
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- Neonatal and Maternal Infections
- Health and Medical Research Impacts
- Hernia repair and management
- Phagocytosis and Immune Regulation
- Patient-Provider Communication in Healthcare
- Gastrointestinal disorders and treatments
- X-ray Diffraction in Crystallography
- Cell death mechanisms and regulation
- Heart Rate Variability and Autonomic Control
- Crystallization and Solubility Studies
Northwell Health
2020-2025
Cohen Children's Medical Center
2023-2025
Feinstein Institute for Medical Research
2022-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020-2025
Long Island Jewish Medical Center
2022-2025
Hofstra University
2022-2024
Icahn School of Medicine at Mount Sinai
2023-2024
North Shore University Hospital
2022-2023
New York Institute of Technology
2016-2020
William & Mary
2017
In 2020, firearm injuries became the leading cause of death among US children and adolescents. This study aimed to evaluate new 2021 data on pediatric deaths disparities understand trends compared with previous years.
Sepsis is characterized by life-threatening organ dysfunction caused a dysregulated host response to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) damage-associated molecular pattern (DAMP) that promotes inflammation and induces cell death via apoptosis, NETosis, and/or pyroptosis. Ferroptosis form of regulated the accumulation lipid peroxide on cellular membranes. We hypothesize eCIRP ferroptosis in macrophages lung tissue during sepsis. RAW 264.7 cells stimulated with...
BACKGROUND AND OBJECTIVES Diagnosis of adnexal torsion is challenging due to variable clinical presentations and often inconclusive imaging results. We hypothesized that diagnostic delays are common, leading prolonged ischemia subsequent tissue loss. aimed identify factors associated with in pediatric patients torsion. METHODS performed a multi-institutional retrospective review females aged 5 18 years confirmed between 2013 2022. Delay care was defined as prior emergency department...
Abstract Background Firearms became the leading cause of death in United States pediatric population 2019 and have persisted as through 2021, with widening racial ethnic disparities. We aimed to examine recent trends U.S firearm mortality, how they differ by intent, identify which ages, groups been most impacted over time. Methods The Centers for Disease Control Prevention Wide-Ranging Online Data Epidemiologic Research database was queried mortalities children aged 0–19 years from...
Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also acquired forms of heart disease including failure (HF) atrial fibrillation (AF). Thus, stabilizing RyR2 may exert therapeutic effects these conditions.The purpose this study was investigate the with chronic dantrolene treatment on HF development AF inducibility a myocardial infarction (MI)-induced model rats.MI induced adult...
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease primarily affecting premature neonates, marked by poorly understood pro-inflammatory signaling cascades. Recent advancements have shed light on subset of endogenous molecular patterns, termed chromatin-associated patterns (CAMPs), which belong to the broader category damage-associated (DAMPs). CAMPs play crucial role in recognizing pattern recognition receptors and orchestrating inflammatory responses. This review focuses...
Extracellular cold-inducible RNA-binding protein (eCIRP) is an endogenous pro-inflammatory mediator that exacerbates injury in inflammation and sepsis. The mechanisms which eCIRP released have yet to be fully explored. Necroptosis a programmed cell death dependent on the activation of mixed lineage kinase domain-like pseudo (MLKL) causes release damage-associated molecular patterns. We hypothesize through necroptosis intensifies sepsis.RAW264.7 cells were treated with pan-caspase inhibitor...
Abstract Sepsis is a life-threatening inflammatory condition partly orchestrated by the release of various damage-associated molecular patterns such as extracellular cold-inducible RNA-binding protein (eCIRP). Despite advances in understanding pathogenic role eCIRP diseases, novel therapeutic strategies to prevent its excessive response are lacking. Milk fat globule-epidermal growth factor-VIII (MFG-E8) critical for opsonic clearance apoptotic cells, but potential involvement removal was...
A three-step domino reaction between 1-aryl-3-hexyne-2,6-diol derivatives and aldehydes is used to construct tricyclic 1,4-dihydro-2H-benzo[f]isochromenes. The cascade initiated by BF3·OEt2 involves alkynyl-Prins cyclization, Friedel-Crafts alkenylation, dehydration/aromatization create a new, central aromatic ring eliminate 2 equiv. of water. Electron-donating substituents on the aryl 1-aryl-3-hexyne-2,6-diols significantly increase overall yields as do electron-rich aldehyde partners. For...
Introduction: Gut ischemia and reperfusion (I/R) injury promotes the release of damage-associated molecular patterns (DAMPs) such as extracellular cold-inducible RNA-binding protein (eCIRP). I/R often leads to acute lung (ALI), a major contributor mortality. Milk fat globule-epidermal growth factor-factor VIII-derived oligopeptide-3 (MOP3) is novel peptide that attenuates sepsis by opsonizing eCIRP facilitating its phagocytic clearance. We hypothesized MOP3 reduces inflammation, mitigates...
This study was aimed to understand the mechanism of persistent cardiac myocyte (CM) survival in myocardial infarction (MI) scars. A transmural MI induced 12-month-old Sprague–Dawley rats by permanent coronary artery ligation. The hearts were collected 3 days, 1, 2, 4, 8, and 12 weeks after evaluated with histology, immunohistochemistry, quantitative morphometry. Vasculature patency assessed 4-, 8-, 12-week-old scars infusion 15-micron microspheres into left ventricle before euthanasia....