A5013473451- dental development and anomalies
- Barrier Structure and Function Studies
- Connexins and lens biology
- Magnesium in Health and Disease
- Cell Adhesion Molecules Research
- Oral and Maxillofacial Pathology
- Wound Healing and Treatments
- Cancer Cells and Metastasis
- Bone and Dental Protein Studies
- Wnt/β-catenin signaling in development and cancer
- Bone Tissue Engineering Materials
- Connective tissue disorders research
- Rice Cultivation and Yield Improvement
- Dental Trauma and Treatments
- Medicinal plant effects and applications
- Proteoglycans and glycosaminoglycans research
- Genetic Mapping and Diversity in Plants and Animals
- Cleft Lip and Palate Research
- Medicinal Plants and Neuroprotection
- GABA and Rice Research
- Hemoglobin structure and function
- Laser Applications in Dentistry and Medicine
- Salivary Gland Disorders and Functions
- Pancreatic function and diabetes
- Hedgehog Signaling Pathway Studies
Kanazawa University
2024
Fukuoka Dental College
2017-2023
University of the Ryukyus
1992
Karolinska Institutet
1957
In tooth root development, periodontal ligament (PDL) and cementum are formed by the coordination with fragmentation of Hertwig's epithelial sheath (HERS) differentiation dental follicle mesenchymal cells. However, function cells after HERS in PDL is not fully understood. Here, we found that TGF-β regulated via epithelial-mesenchymal transition (EMT), fragmented differentiated into fibroblastic expressing extracellular matrix (ECM). histochemical analysis, was expressed odontoblast layer...
Transient receptor potential melastatin-7 (TRPM7) is a bi-functional protein containing kinase domain fused to an ion channel. TRPM7 highly expressed in ameloblasts during tooth development. Here we show that kinase-inactive knock-in mutant mice (TRPM7 KR mice) exhibited small enamel volume with opaque white-colored incisors. The channel function of ameloblast-lineage cells from was normal. Interestingly, phosphorylation intracellular molecules including Smad1/5/9, p38 and cAMP response...
During palatogenesis, the palatal shelves first grow vertically on either side of tongue before changing their direction growth to horizontal. The extracellular matrix (ECM) plays an important role in these dynamic changes shelf morphology. Tenascin-C (TNC) is ECM glycoprotein that shows unique expression posterior part shelf, but little known about regulation TNC expression. Since transforming factor-beta-3 (TGF-β3) and sonic hedgehog (SHH) signaling are play roles we investigated whether...
The development of bio-three-dimensional (bio-3D) printers has led to significant advances in regenerative medicine. Three-dimensional constructs, including spheroids, are maintained by extracellular matrix proteins secreted cells so that the can be cultured conditions closer physiological environment. This study aimed create a useful 3D construct as model dentin-pulp complex.
An extremely early line of rice, T65·ER-20, was bred after 8 times backcrossings, using two heading lines, Kokusyokuto-2 harboring several unknown earliness genes besides the gene Ef-1 as a donor parent genes, and an isogenic Taichung 65 (T65) (T65·ER-1) recurrent parent. Since individuals segregated in 3:1 ratio B8F2 generation 1:1 B9F1, T65·ER-20 harbors new dominant gene, Ef-x, gene. T65·ER-21 having also bred. Segregation mode for time F2 plants showing disgenic segregation different...
The treatment of ulceration or stomatitis with laser therapy is known to accelerate healing and relieve pain, but the underlying biological mechanism not fully understood. present study used a mouse model investigate molecular mechanisms by which CO₂ accelerated wound process. An ulcer was experimentally created in palatal mucosa irradiated light from laser. Compared controls (no irradiation), irradiation induced proliferation epithelial cells faster re-epithelialization area....
Abstract Retinoic acid (RA) plays an important role in epithelial homeostasis and influences the morphology, proliferation, differentiation permeability of cells. Mouse keratinocytes, K38, reconstituted non-keratinized stratified epithelium three-dimensional (3D) cultures with serum, which contains retinol (a source RA), but morphology was different from vivo epithelium. The formed thick, loosened cell–cell contacts. Here, we investigated whether inhibition RA receptor (RAR)/retinoid X...
Cyclophosphamide (CPA) is a commonly used chemotherapeutic agent to treat cancer. Among its many side effects the well-known consequence on tooth development when administered at early ages. This study elucidated of CPA mandibular molar in mice. Mice received single intraperitoneal injection different doses and times. treatment led weight loss alopecia but had no effect disturbances eruption or crown shape. However, higher doses, there was arrested root apical foramen closure histologically...
Abstract Transient receptor potential melastatin 7 (TRPM7) is a unique ion channel connected to kinase domain. We previously demonstrated that Trpm7 expression high in mouse ameloblasts and odontoblasts, amelogenesis impaired TRPM7 kinase‐dead mice. Here, we analyzed function during Keratin 14‐Cre;Trpm7 fl/fl conditional knockout (cKO) mice knockdown cell lines. cKO showed lesser tooth pigmentation than control broken incisor tips. Enamel calcification microhardness were lower Electron probe...