A5101941713- Epilepsy research and treatment
- Mass Spectrometry Techniques and Applications
- Ion-surface interactions and analysis
- Pharmacological Effects and Toxicity Studies
- Education and Learning Interventions
- SARS-CoV-2 and COVID-19 Research
- Psychosocial Factors Impacting Youth
- Vascular Malformations and Hemangiomas
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Viral gastroenteritis research and epidemiology
- Ear and Head Tumors
- Peripheral Neuropathies and Disorders
- Advanced Proteomics Techniques and Applications
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Autoimmune Neurological Disorders and Treatments
- Ion channel regulation and function
- COVID-19 Clinical Research Studies
- Head and Neck Surgical Oncology
- Hereditary Neurological Disorders
- Ion Channels and Receptors
- Respiratory viral infections research
- Influenza Virus Research Studies
BC Centre for Disease Control
2022-2023
University of British Columbia
2023
Simon Fraser University
2023
Ministry of Health of the Russian Federation
2023
Chonnam National University
2023
Myongji Hospital
2013-2020
Hanyang University
2020
Inje University Haeundae Paik Hospital
2020
Myongji University
2019
Korea Research Institute of Standards and Science
2011-2018
Organ development requires complex signaling by cells in different tissues. Epithelium and mesenchyme interactions are crucial for the of skin, hair follicles, kidney, lungs, prostate, major glands, teeth. Despite myriad literature on cell-cell ligand-receptor binding, roles extracellular vesicles epithelium-mesenchyme during organogenesis poorly understood. Here, we discovered that ∼100 nm exosomes were secreted epithelium a developing tooth organ diffused through basement membrane....
The Canadian Sentinel Practitioner Surveillance Network estimated vaccine effectiveness (VE) during the unusually early 2022/23 influenza A(H3N2) epidemic. Like vaccine, circulating viruses were clade 3C.2a1b.2a.2, but with genetic diversity affecting haemagglutinin positions 135 and 156, reassortment such that H156 acquired neuraminidase from 3C.2a1b.1a. Vaccine provided substantial protection VE of 54% (95% CI: 38 to 66) overall. was similar against vaccine-like S156 viruses, potential...
The objective of this study was to evaluate the role resective pediatric epilepsy surgery for Lennox-Gastaut syndrome (LGS).We analyzed clinical data 27 children and adolescents who had LGS underwent despite abundant (>30% preoperative interictal and/or ictal epileptiform discharges) generalized or contralateral maximal multiregional electroencephalogram abnormalities.On high-resolution MRI, cerebral lesions were noted in 23 (85.2%) patients but not 4 (14.8%) patients. age at time between...
Abstract Background Two- and 3-dose BNT162b2 vaccine effectiveness (VE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including Delta Omicron variants, was assessed among adolescents in Canada, where first second doses were spaced longer than the manufacturer-specified 3-week interval. Methods Test-negative design estimated VE laboratory-confirmed SARS-CoV-2 infection ≥14 days after vaccination 12–17-year-olds Quebec British Columbia, between 5 September...
Influenza virus circulation virtually ceased in Canada during the COVID-19 pandemic, re-emerging with relaxation of restrictions spring 2022. Using a test-negative design, Canadian Sentinel Practitioner Surveillance Network reports 2021/22 vaccine effectiveness 36% (95% CI: -38 to 71) against late-season illness due influenza A(H3N2) clade 3C.2a1b.2a.2 viruses, considered antigenically distinct from 3C.2a1b.2a.1 strain. Findings reinforce World Health Organization's decision update 2022/23...
Corn seed tissue sections were prepared by the tape support method using an adhesive tape, and mass spectrometry imaging (MSI) was performed. The effect of heat generated during sample preparation investigated time-of-flight secondary (TOF-SIMS) corn thaw-mounted methods. Unlike preparation, does not cause distortion because absence heat, which can migration analytes on sample. By applying tape-support method, without structural damage MSI with accurate spatial information successfully...
Population-based cross-sectional serosurveys within the Lower Mainland, British Columbia, Canada, showed about 10%, 40% and 60% of residents were infected with SARS-CoV-2 by sixth (September 2021), seventh (March 2022) eighth (July serosurveys. We conducted ninth (December tenth 2023) sought to assess risk severe outcomes from a first-ever infection during intersurvey periods.Using increments in cumulative infection-induced seroprevalence, population census, discharge abstract vital...
We demonstrate that the microwave-assisted protein enzymatic digestion (MAPED) method can be successfully applied to mass spectrometric characterization of proteins captured on affinity surfaces chips. The on-chip tryptic was developed using a domestic microwave, completing proteolysis reaction in minutes, whereas previous methods by incubation took hours time. For model chips, antibody-presenting were prepared, where anti-α-tubulin1 and antibovine serum albumin (BSA) immobilized...
This study investigated the long-term efficacy, safety, and compliance associated with sublingual immunotherapy (SLIT) in Korean patients allergic rhinitis sensitized to house dust mites.This is a retrospective cohort study. A total of 164 who were Dermatophagoides pteronyssinus farinae received SLIT enrolled between November 2007 January 2010. Each patient was followed up using diary card, on which symptom score, rescue medication adverse events (AEs) recorded.All symptoms improved after 3...
Relapsed herpes simplex virus (HSV) encephalitis after neurosurgery is a very rare condition.An 11-year-old boy suffered from relapsed HSV five days to remove the epileptogenic focus six years prior encephalitis.He was diagnosed with reactivation positive polymerase chain reaction results following lumbar puncture, and this diagnosis supported by consistent radiologic histopathologic findings.Moreover, focal cortical dysplasia coexisted inflammatory changes resulting viral infection based...
Background Inflammation is an important underlying mechanism in the pathogenesis of atherosclerosis, and elevated resting heart rate underlies process atherosclerotic plaque formation. We hypothesized association between subclinical inflammation. Methods Resting was recorded at baseline KoGES-ARIRANG (Korean Genome Epidemiology Study on Atherosclerosis Risk Rural Areas Korean General Population) cohort study, then divided into quartiles. Subclinical inflammation measured by white blood cell...
Reported herein are high-color-rendering index two-stack phosphorescent tandem white organic light-emitting diodes using three-color dopants: iridium(III) bis(3,5-difluoro-2-(2-pyridyl)phenyl-(2-carboxypyridyl) (472 nm) as a blue emitter for the first stack layer, and bis(4-methyl-2-(3,5-dimethylphenyl)quinolinato-N,C2′) tetramethylheptadionate (612 bis(4-(4-tbutylphenyl)thieno[3,2-c]pyridinato-N,C2′)acetylacetonate (562 red yellow triplet emitters second respectively. By locating emissive...
The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant anti-inflammatory effects. It shown a protective effect on kanamycin (KM)-induced ototoxicity mouse model. In the present study, we administered at different time points after inducing hair cell damage, examined if it rescues loss restores hearing. A deaf model was created by intraperitoneal injection of KM furosemide. First, to test early temporal change hearing extent...
We investigated the thermal mechanism involved in laser desorption/ionization (LDI) of thermally labile molecules from flat surfaces amorphous Si (a-Si) and crystalline (c-Si). a-Si was selected for this study because its property, such as low conductivity; thus, it predicted to be highly susceptible laser-induced surface heating. By virtue lack nanostructures, offer a simple model system focus on mechanism, avoiding other effects, including possible non-thermal contributions that can arise...
Rett syndrome is a severe neurodevelopmental disorder in females. Most have mutations the methyl-CpG-binding protein 2 (MECP2) gene (80-90%). Epilepsy significant commonly accompanied feature syndrome. Our study was aimed at comprehensive analysis of genetic and clinical features patients, especially regards to epileptic features.We retrospectively reviewed 20 patients who were diagnosed with MECP2 Severance Children's Hospital between January 1995 July 2010. All met criteria for Evaluations...
Brain imaging using time-of-flight secondary ion mass spectrometry (ToF-SIMS) has been reported to produce the distorted biomolecular distributions due cholesterol-induced matrix effect when cholesterol migrates surface, particularly in white matter, which contains a high level of cholesterol. Frozen-hydrated analysis used inhibit movement brain. In this paper, authors propose new sample preparation and drying methods that can be obtain accurate images at room temperature, instead...