A5062869343- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- GDF15 and Related Biomarkers
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Obstructive Sleep Apnea Research
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Sex and Gender in Healthcare
- Genetic Associations and Epidemiology
- Complement system in diseases
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular and Diving-Related Complications
- Regulation of Appetite and Obesity
- Cardiac Health and Mental Health
- Cerebrospinal fluid and hydrocephalus
- Heart Rate Variability and Autonomic Control
- Peroxisome Proliferator-Activated Receptors
University Hospital Regensburg
2012-2024
University of Regensburg
2011-2024
University Medical Center
2016
University of Bonn
1992-2015
University Clinical Centre
2012
Abstract Background Beyond the degree of adiposity, pattern fat distribution has a profound influence on cardiometabolic risk. It is unclear if sex differences in body can potentially explain any prevalence metabolic syndrome (MetS) and individual risk factors among obese men women. Methods In this cross-sectional analysis, 432 persons from ongoing Obesity Weight Reduction Study ( n = 356 obese, ØBMI 41 ± 8 kg/m 2 , 76 non-obese, 25 3 ), were included. The relations to MetS selected assessed...
Obesity and the metabolic syndrome (MetS) are risk factors for left ventricular diastolic dysfunction (LVDD). However, little is known about impact of successful weight reduction (WR) on function physical performance.Obese subjects (øBMI 40.2 ± 8.6 kg/m2) underwent a 1-year WR program comprising diet lifestyle components. Echocardiography exercise capacity (6-minute walk) were performed at baseline after 1 year. The distribution was split sample median dichotomized in "successful WR" (% ≥...
BackgroundCardiac autonomic dysfunction after myocardial infarction identifies patients at high risk despite only moderately reduced left ventricular ejection fraction. We aimed to show that telemedical monitoring with implantable cardiac monitors in these can improve early detection of subclinical but prognostically relevant arrhythmic events.MethodsWe did a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial 33 centres Germany and Austria. Survivors...
This study aimed to examine the association of adipocyte fatty acid-binding protein (FABP4) levels with left ventricular diastolic dysfunction (LVDD) in obese subjects varying degrees metabolic syndrome (MetS).Fifty morbidly LVDD were selected at random and matched by age (±5 years) sex 50 normal (LV) function. In addition, 24 healthy lean included as controls.Median FABP4 (interquartile range) significantly higher (42 ng ml(-1) (32-53)) than LV function (24 (36-43), P=0.036), weight...
Kardiovaskuläre Erkrankungen sind weltweit sowohl bei Männern als auch Frauen die führende Todesursache. Durch fokussierte klinische und wissenschaftliche Untersuchungen hat sich das Verständnis für geschlechterspezifische Unterschiede in der Prävalenz, Pathophysiologie klinischen Präsentation von Herz-Kreislauf-Erkrankungen deutlich verbessert. Es ist mittlerweile unbestritten, dass kardiovaskuläre beiden Geschlechtern nicht immer identisch manifestieren, sondern Anatomie, Ätiologie,...
Abstract Aims Left ventricular diastolic dysfunction (LVDD) is common in obese subjects, and a relationship between epicardial adipose tissue (EAT), increased adipocytokines, cardiovascular diseases has been reported. This study sought to examine as whether the adipo‐fibrokine activin A link EAT, metabolic syndrome (MetS), LVDD severely subjects. Methods results In 236 subjects (ø body mass index 39.8 ± 7.9 kg/m 2 ) with variable degree of MetS 60 healthy non‐obese controls 24.8 3.4 ), serum...
Knowledge of the association between single nucleotide polymorphisms (SNPs) and weight loss is limited. The aim was to analyse whether selected obesity-associated SNPs within fat mass (FTO), transmembrane protein 18 (TMEM18), melanocortin-4 receptor (MC4R), SEC16 homolog B (SEC16B), brain-derived neurotrophic factor (BDNF) gene are associated with anthropometric changes during behavioural intervention for loss. genetic data from 576 individuals overweight obesity four lifestyle interventions...
Aim: Multimer complex formation of adiponectin is recognized as an important mechanism modulating the biological functions this adipokine, but role isoforms in myocardial infarction (MI) still unclear.Methods: We quantified total (TOTAL), high, middle, and low molecular weight multimers (HMW, MMW, LMW) a study non-diabetic obese (BMI ≥ 30 kg/m2) normal-weight ≤ 25 male subjects with MI healthy controls (n=180). Subsequently, we designed prospective nested-case-control to investigate...
This study sought to examine the relationships between right ventricular (RV) function and geometry, morbid obesity with without metabolic syndrome, effect of long-term weight loss. Obese (n = 153, BMI 41.2 ± 8.7 kg/m(2)) healthy non-obese control subjects 38, 25.5 3.3 similar age gender distribution were prospectively studied during course a 1-year reduction program echocardiography at baseline after one year follow up. Function geometry heart evaluated by tricuspid annular plane systolic...
Abstract Background Lowering LDL-cholesterol is a fundamental goal for both primary and secondary prevention of atherosclerotic cardiovascular diseases. Our study aims to analyse potential sex disparities regarding the tolerability effectiveness lipid-lowering therapy in patients with without reported statin intolerance who are being treated at lipid-outpatient clinic. Methods From 2017 2022, n = 1062 ( 612 men, 450 women) high-risk were referred our clinic because difficulties lipid control...
Aim: In subjects with metabolic syndrome (MetS) endothelial dysfunction is a very consistent finding. Processes leading to and atherosclerosis involve the altered control of subclinical inflammation by innate immune defenses that possibly include mannose-binding lectin (MBL). We investigated associations MBL traits MetS early in obese before after marked weight reduction.Methods: prospective longitudinal study, concentrations 96 severely without (Ø BMI 41.0±7.9kg/m2, Ø 39.4±7.7kg/m2) were...
Some years ago, Nidek developed a new imaging system for the anterior eye segment, which offers possibility of recording Scheimpflug and retroillumination images. The consists 2 different technical units, camera unit image computer storage, operation analysis. To evaluate clinical use its reproducibility, study with 31 volunteers/patients was performed that were photographed EAS 1000 at meridians 0°, 45° 180°. Two examinations 1-week interval performed. In addition, direct comparison Topcon...
Background: Prolongation of the QT interval has been related to various components metabolic syndrome (MetS), including type 2 diabetes and obesity. The underlying mechanisms QTc prolongation in these subjects are still unknown. We conducted a prospective study determine ventricular repolarization parallel detailed parameters during course standardized weight reduction. Methods: In longitudinal QTc-interval (QTc) was determined severely obese (n= 221, mean BMI 40,8±8,2 kg/m2) with without...
Abstract Background and objectives Atrial fibrillation is common in patients with chronic heart failure associated poor outcome these patients. Plasmatic NT-proBNP represents the gold standard biomarker for failure. Further, recent studies showed prognostic impact of urinary NT-proBNP. Aim study was to assess association plasmatic as well atrial a cohort implantable cardioverter defibrillator (ICD). Methods 412 were included study. Fresh spot urine blood samples used Urinary normalized...
Abstract Background and objectives Atrial fibrillation is common in patients with chronic heart failure associated poor outcome these patients. Plasmatic NT-proBNP represents the gold standard biomarker for failure. Further, a recent analysis showed strong association of plasmatic atrial (AFib). Aim study was to assess depending on left ventricular ejection fraction (LVEF) cohort implantable cardioverter defibrillator (ICD). Methods 412 were included study. Blood samples used NT-proBNP....
Aim: The study focused on biomarkers of kidney injury as predictors mortality in patients with chronic heart failure (CHF) a long-term follow-up (median 104 months). Methods/results: KIM-1, NAG and NGAL were assessed from urine, NT-proBNP blood samples. 149 (age 62 ± 12 years) CHF (mean EF 30% [IQR 24-40%]) enrolled. 79 (53%) died. Cox regression analysis revealed Log2NAG (HR: 1.46, CI: 1.12-1.89), Log2KIM-1 1.23, 1.02-1.49) Log2NT-proBNP 1.50, 1.32-1.72) significant all-cause opposed to...
Chronic heart failure may lead to chronic kidney disease. Previous studies suggest tubular markers N-acetyl-b-D-glucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential for the cardiorenal syndrome (CRS). The prognostic value of NAG KIM-1 regarding implantable cardioverter defibrillator (ICD) shock therapies is unknown.We included 314 patients with an ICD collected plasma urine samples. Urine-values got related urinary creatinine. Outcomes interest were sustained adequate a...
Genome wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small. Therefore, the aim our study was to investigate whether a genetic risk score (GRS) comprising alleles in GIANT consortium meta-analyses shows body mass index (BMI) and other BMI related metabolic alterations cohort an extreme phenotype. Genotyping 93 performed 314 obese individuals (mean 40.5 ± 7.8 kg/m², aged 45 12 years),...
Aim: We assessed the 10-year prognostic role of 11 biomarkers with different pathophysiological backgrounds. Materials & methods/results: Blood samples from 144 patients heart failure were analyzed. After 10 years follow-up (median was 104 months), data regarding all-cause mortality acquired. Regarding Kaplan-Meier analysis, all markers, except TIMP-1 and GDF-15, significant predictors for mortality. created a multimarker model nt-proBNP, hs-TnT IGF-BP7 found that in whom three markers...