A5101869812- Forensic and Genetic Research
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Yersinia bacterium, plague, ectoparasites research
- Race, Genetics, and Society
- Parkinson's Disease Mechanisms and Treatments
- DNA and Nucleic Acid Chemistry
- Animal Disease Management and Epidemiology
- Genomics, phytochemicals, and oxidative stress
- Enzyme function and inhibition
- RNA regulation and disease
- Glutathione Transferases and Polymorphisms
- Autophagy in Disease and Therapy
- Pharmacology and Obesity Treatment
- RNA Research and Splicing
- Cardiac Ischemia and Reperfusion
- Endoplasmic Reticulum Stress and Disease
- Bioactive Compounds and Antitumor Agents
- Calcium signaling and nucleotide metabolism
- Viral gastroenteritis research and epidemiology
- Bioinformatics and Genomic Networks
- Metal complexes synthesis and properties
- Gut microbiota and health
University of Maryland, Baltimore
2025
Celerion (United States)
2024
Zhejiang A & F University
2022-2023
Fudan University
2015-2022
Zunyi Medical University
2016-2019
University of Michigan–Ann Arbor
2018-2019
University of Wisconsin–Milwaukee
2014-2015
Jinan University
2012
Increasing quantitative data generated from transcriptomics and proteomics require integrative strategies for analysis. Here, we present an R package, clusterProfiler that automates the process of biological-term classification enrichment analysis gene clusters. The module visualization were combined into a reusable workflow. Currently, supports three species, including humans, mice, yeast. Methods provided in this package can be easily extended to other species ontologies. is released under...
Reducing host toxicity is one of the main challenges cancer chemotherapy. Many tumor cells contain high levels ROS that make them distinctively different from normal cells. We report a series ROS-activated aromatic nitrogen mustards selectively kill chronic lymphocytic leukemia (CLL) over lymphocytes. These agents showed powerful DNA cross-linking abilities when coupled with H2O2, most common in cells, whereas little was detected without H2O2. Consistent chemistry observation, vitro...
Abstract Three novel H 2 O ‐activated aromatic nitrogen mustard prodrugs ( 6 – 8 ) are reported. These compounds contain a DNA alkylating agent connected to ‐responsive trigger by different electron‐withdrawing linkers so that they inactive towards but can be triggered release active species. The activity and selectivity of these were investigated measuring interstrand cross‐link (ICL) formation in the presence or absence . An linker unit, such as quaternary ammonia salt ), carboxyamide 7...
We pursued a structure-guided approach toward the development of improved dihydroorotate dehydrogenase (DHODH) inhibitors with goal forming new interactions between DHODH and brequinar class inhibitors. Two potential residues, T63 Y356, suitable for novel H-bonding interactions, were identified in brequinar-binding pocket. Analogues designed to maintain essential pharmacophore form electrostatic through strategically positioned H-bond accepting groups. This effort led discovery potent...
Modern East Asians derived from the admixture of aborigines and incoming farmers expanding Yellow Yangtze River Basins. Distinct genetic differentiation subsequent between North South subsequently evidenced by mitochondrial DNA, Y-chromosomal variations autosomal SNPs. Recently, population geneticists have paid more attention to polymorphisms background southern-Han Chinese southern native populations. The legacy northern-Han remains uncharacterized. Thus, we performed this comprehensive...
Abstract Avacopan, a complement 5a receptor (C5aR) antagonist approved for treating severe active antineutrophil cytoplasmic autoantibody (ANCA)‐associated vasculitis, was evaluated in 2 clinical drug‐drug interaction studies. The studies assessed the impact of avacopan on pharmacokinetics (PK) CYP3A4 substrates midazolam and simvastatin CYP2C9 substrate celecoxib, influence inhibitor itraconazole inducer rifampin PKs avacopan. results indicated that twice‐daily oral administration 30 mg...
Abstract Short tandem repeats (STRs) located on the Y chromosome with properties of male-specific inheritance and haploidy are widely used in forensics to analyze paternal genealogies match male trace donors evidence. Besides, Y-chromosomal haplotypes play an important role providing breathtaking insights into population genetic history. However, diversity forensic characteristics Y-STRs Guizhou main ethnic groups (Hans, Miaos Bouyeis) remain uncharacterized. Here, we obtained 23-marker...
Abstract X-chromosome short tandem repeat markers (X-STRs), due to their special inheritance models, physical location on a single chromosome and the absence of recombination in male meiosis, play an important role forensic population genetics. While series genetic analyses focusing diversity characteristics X-STRs are well studied for ethnically/linguistically diverse demographically large Chinese populations, evidence from Gelao ethnicity is still sparse. Here, we genotyped first batch 19...
X-chromosomal short tandem repeats (X-STRs) may assist resolution of complex forensic kinship cases and complement autosomal Y-chromosomal STRs in routine practice population genetics. In the present study, we investigated allele/haplotype diversity genetic characteristics 19 X- 206 Guizhou Han 1344 Meta-Han Chinese individuals using AGCU X19 PCR amplification system. Population relationships within five groups (1344 individuals), between other reference populations belonging to four...
Using reported glutathione S-transferase omega 1 (GSTO1-1) cocrystal structures, we designed and synthesized acrylamide-containing compounds that covalently bind to Cys32 on the catalytic site. Starting from a thiazole derivative 10 (GSTO1-1 IC50 = 0.6 μM), compound 18 was cocrystallized with GSTO1. Modification amide moiety of hit significantly increased GSTO1-1 inhibitory potency. We solved structures new derivatives, 37 44, bearing an side chain bound These showed reorientation phenyl...
Bovine viral diarrhea virus (BVDV) is the causative agent of bovine diarrhea-mucosal disease, which a leading cause economic losses in cattle industry worldwide. To date, many underlying mechanisms involved BVDV-host interactions remain unclear, especially functions long noncoding RNAs (lncRNAs). In our previous study, lncRNA expression profiles BVDV-infected Madin-Darby kidney (MDBK) cells were obtained by RNA-seq, and significantly downregulated IALNCR targeting MAPK8/JNK1 (a key...
Four novel photoactivated binitroimidazole prodrugs were synthesized. These agents produced DNA interstrand cross-links (ICLs) and direct strand breaks (DSB) upon UV irradiation, whereas no or very few ICLs DSBs observed without treatment. Although these four molecules (1-4) contain the same moiety, they bear different leaving groups, which resulted in their producing yields of damage. Compound 4, with nitrogen mustard as a group, showed highest ICL yield. Surprisingly, compounds 1-3, any...
Abstract Taurine, which is found at high concentration in the heart, exerts several protective actions on myocardium. Physically, level of taurine heart maintained by a transporter (TauT), expression suppressed under ischemic insult. Although supplementation upregulates TauT expression, elevates intracellular content and ameliorates injury cardiomyocytes (CMs), little known about regulatory mechanisms governing ischemia. In this study, we describe TonE (tonicity-responsive element)/TonEBP...
Investigation of haplotype/allele frequency data Y-STR loci in ethnically diverse populations is essential for forensic reference database construction and genetic application. However, the population characteristics Chinese Miao minority from Guizhou Province remain uncharacterised.To assess 23 Y-Chromosomal STR explore relationships with geographically neighbouring populations.Twenty-three STRs were genotyped using Powerplex® Y23 system 103 unrelated males Province, southwest China....
Allele frequency data and forensic statistical parameters were determined for 20 autosomal short tandem repeat (STR) loci of the PowerPlex 21 System in 214 unrelated healthy individuals a Uyghur ethnic minority group living Xinjiang province, northwest China. A total 232 alleles observed with corresponding allele frequencies ranging from 0.0023 to 0.5304. All consistent Hardy–Weinberg equilibrium (HWE) after Bonferroni correction (p > 0.0025). The combined probability exclusion, power...
Human E3 ubiquitin protein ligase parkin (Parkin) mediates mitophagy to maintain mitochondrial homeostasis. Parkin mutations are common genetic causes of early onset familial Parkinson's disease. The molecular mechanism activation has been widely studied with emerging evidence suggesting an essential role the phosphorylated (phospho)‑ubiquitin interaction. However, underlying mecha-nism phospho‑ubiquitin interaction remains elusive. In present study, replica exchange dynamics simulations...