A5019711696- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Child Nutrition and Feeding Issues
- Protein Degradation and Inhibitors
- Helicobacter pylori-related gastroenterology studies
- Clinical Nutrition and Gastroenterology
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Medical and Biological Ozone Research
- Restraint-Related Deaths
- Wound Healing and Treatments
- Hydrogen's biological and therapeutic effects
- Spine and Intervertebral Disc Pathology
- Pregnancy and Medication Impact
- DNA Repair Mechanisms
- Healthcare Decision-Making and Restraints
- Tumors and Oncological Cases
- RNA regulation and disease
- Ear and Head Tumors
Wuhan Third Hospital
2021-2025
Tongren Hospital
2021-2025
Second Affiliated Hospital of Zhejiang University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2024
University of Maryland, Baltimore
2019-2022
First Affiliated Hospital of Anhui Medical University
2021-2022
Anhui Medical University
2018-2022
Zhejiang University
2021-2022
The Royal Wolverhampton NHS Trust
2019-2020
Melanoma is a highly invasive malignancy with poor prognoses in advanced stages. Developing risk model that can accurately assess prognosis and guide personalized treatment crucial for improving the clinical management of melanoma. This study aims to develop validate an immune-based prognostic melanoma through comprehensive bioinformatics analysis. We collected transcriptomic data from multiple public databases identified 9 immune features significantly associated using single-sample Gene...
A single-day hospital-acquired infections (HAIs) point prevalence study was conducted in a tertiary care hospital China. The overall rate of HAIs 3.53% (95% confidence interval 2.80-4.26%) among 2434 inpatients surveyed. Respiratory system infection the most common type HAI (49.43%), followed by surgical site (22.99%). pathogen detection results for 50 patients showed Pseudomonas aeruginosa to account 24.00% isolates, Klebsiella pneumoniae (14.00%) and Escherichia coli (14.00%).
Objective Although N 6 -methyladenosine (m A) RNA methylation is the most common mRNA modification process, few studies have examined role of m A in stomach adenocarcinomas (STADs). Methods In this retrospective study, we analyzed 293 STAD samples from The Cancer Genome Atlas with complete clinicopathological feature profiles. risk signature was derived LASSO–Cox regression analyses 15 regulators. Statistical analysis performed and figures were prepared using R software (...
Abstract Aim and objectives To identify the practice variation of individual practitioners in medications’ formulation modification for patients using enteral feeding tubing to support health involved this process. Background Blockage tubes is a common problem that can sometimes be resolved but may require replacement tube. Medications are culprit. Design A survey 73 registered nurses’ practices around medication administration via tubes. Methods questionnaire study was undertaken within...
Abstract Infection with flaviviruses, such as dengue virus (DENV) and the recently re-emerging Zika (ZIKV), represents an increasing global risk. Targeting essential host elements required for flavivirus replication attractive approach discovery of antiviral agents. Previous studies have identified several components Hrd1 ubiquitin ligase-mediated endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, a cellular protein quality control process, factors crucial DENV ZIKV...
RNF5 E3 ubiquitin ligase has multiple biological roles and been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, certain viral infections, emphasizing importance discovering small-molecule modulators for research drug development. The present study describes synthesis a new benzo[b]thiophene derivative, FX12, that acts selective inhibitor degrader RNF5. We initially identified previously reported STAT3 inhibitor, Stattic, an dislocation misfolded...
Objective: To compare the effectiveness of an intercostal nerve block after costal cartilage harvest when a multimodal cocktail or ropivacaine plus patient-controlled analgesia is used, as measured by visual analog scale (VAS) scores, rescue analgesic consumption, and related complications. Materials Methods: Eligible patients who underwent were equally randomized to receive (multimodal group) (ropivacaine group). Results: Of 112 assessed, 12 (10.7%) excluded 100 (89.3%) enrolled assigned...
Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine relapsing remitting manner. In dextran sulfate sodium (DSS)-induced UC model female mice, we found that levels cyclic guanosine monophosphate (cGMP) are reduced, while expression phosphodiesterase 9A (PDE9A) highest among all (PDEs). Since PDE9 has affinity toward cGMP, evaluated selective inhibitor PF-04447943 (PF) potential candidate for treatment. PF...
Tumor-infiltrating lymphocytes (TILs) in gastric cancer are closely related to clinical prognosis; however, little is known regarding the immune microenvironment this disease. Thus, RNA-sequencing data from patients were downloaded Gene Expression Omnibus (GEO). The proportion of cells was determined based on a deconvolution algorithm (CIBERSORT), and gene expression profiles analyzed context outcomes construct an risk score. Data using least absolute shrinkage selection operator (LASSO)...
<p>Health care workers (HCWs) are exposed to blood and body fluids (BBF) due occupational accidents. However, few studies have investigated the prevalence of exposure in Chinese HCWs thus far. There is a clearly critical need characterize its epidemiology more fully China so that effective prevention programs can be implemented. We conducted retrospective study at university hospital China, giving an epidemiological analysis on these whose pathogens BBF from patients were positive...
XBP1 variant 1 (Xv1) is the most abundant and highly enriched across cancer types but nearly none in normal tissues. Its expression associated with poor patients' survival specifically required for of malignant cells, underlying mechanism not known. Here we report that Xv1 upregulates polyglutamylase tubulin tyrosine ligase-like 6 (TTLL6) promotes mitosis cells. Like canonical XBP1, mRNA undergoes unconventional splicing by IRE1α under endoplasmic reticulum stress, it also constitutively...
Minute gastric cancers (MGCs) have a favorable prognosis, but they are too small to be detected by endoscopy, with maximum diameter ≤ 5 mm.
Since the pioneering use of autologous costal cartilage for microtia reconstruction, significant progress has been made in treating microtia, effectively improving patients' quality life and reducing their psychological burden. Cartilage auricle reconstruction is primary treatment, but many postoperative complications can occur. Common include infection hematoma at recipient site, pleural tears donor thoracic scoliosis. Among these, severe pneumonia a rare potentially fatal complication....
Objective To observe the effect of medical ozone gas on human epidermal cells in vitro by simulating bath treatment. Methods Normal skin tissue was taken, and primary culture were digested separated. The third generation used for experimental intervention 50 mg/L environment. (1) Observe inherited cells, cell morphological apoptosis changes Hoechst 33258 staining; (2) Cell viability assay divided into oxygen group (n=5), counting kit-8 (CCK-8) method enzymatic marke employed to detect...
Background: Observational studies have suggested a bidirectional association between inflammatory bowel disease (IBD) and psoriasis. However, the causality of associations is unclear because difficulty determining sequential temporality.Methods: Independent genetic variants for IBD psoriasis were selected as instruments from published genome-wide (GWAS). Summary-level statistics instrument–outcome retrieved three separate databases (IBD Genomics Consortium European Bioinformatics Institute...