A5101752219- Natural product bioactivities and synthesis
- Ziziphus Jujuba Studies and Applications
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Biochemical effects in animals
- Protein Hydrolysis and Bioactive Peptides
- Autophagy in Disease and Therapy
- Dermatology and Skin Diseases
- Proteins in Food Systems
- Wound Healing and Treatments
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Polysaccharides and Plant Cell Walls
- Chromatography in Natural Products
- Coenzyme Q10 studies and effects
- melanin and skin pigmentation
- Biological Activity of Diterpenoids and Biflavonoids
- Lipid metabolism and disorders
- Transgenic Plants and Applications
- Biological and pharmacological studies of plants
- Bee Products Chemical Analysis
- Toxin Mechanisms and Immunotoxins
Changchun University of Chinese Medicine
2012-2025
Hangzhou DAC Biotech (China)
2025
Nanjing Drum Tower Hospital
2025
Peking University
2024
Dalian Medical University
2024
Second Affiliated Hospital of Dalian Medical University
2024
Jilin Jianzhu University
2023
Henan University of Technology
2022
Changchun University
2010
Polysaccharides from Panax ginseng C. A. Meyer (P. ginseng) are the main active component of P. and exhibit significant intestinal anti-inflammatory activity. However, therapeutic mechanism polysaccharide is unclear, this hinders application for medicine or functional food. In study, a was isolated (GP). The primary structure morphology GP were studied by HPLC, FT-IR spectroscopy, scanning electron microscopy (SEM). Further, its activity function evaluated in experimental systems using...
Two new p-hydroxybenzoic acid glycosides, namely acid-4-O-α-d-manopyranosyl-(1 → 3)-α-l-rhamnopyranoside (compound 1) and 4-O-α-l-rhamnopyran-osyl-(1 6)-α-d-manopyranosyl-(1 2), seven known compounds, compound 3, 6, 7 (acid components), 8, 9 (flavonoids), 4 (a coumarin) 5 (an alkaloid), were isolated from the 70% ethanol aqueous extract of aerial parts Melilotus officinalis (Linn.) Pall. The structures all compounds elucidated by use extensive spectroscopic methods Infrared Spectroscopy...
Hedansanqi Tiaozhi Tang extract (HTT) consists of Notoginseng, Danshen, Hawthorn and Lotus leaf from traditional Chinese medicine, which has significant therapeutic effects on hyperlipidemia in patients with non-alcoholic fatty liver disease (NAFLD).This study sought to evaluate the pharmacological molecular mechanism HTT for treatment adipocytes animal model NAFLD.Quantitative phytochemical analysis was performed by HPLC. Antioxidant activity adipogenesis 3T3-L1 cells were assessed. In rat...
Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F . Chow [Rhamnaceae; Ziziphi Spinosae Semen (ZSS)] has attracted extensive attention as the first choice of traditional Chinese medicine in treatment insomnia. However, recent studies on sleep-improving mechanism ZSS have mainly focused role single components. Thus, to further reveal potential ZSS, an assessment its multiple constituents is necessary. In this study, extract (ZSSE) was obtained from via detailed modern extraction, separation, and...
Extracellular matrix (ECM) and angiogenesis are critical controls of wound regeneration, their dysfunction delays diabetes recovery. CXXC5 belongs to the CXXC protein family that can regulate function human dermal fibroblasts (HDFs) umbilical vein endothelial cells (HUVECs); However, awareness its functional role remains limited. Mice were divided into control (CON), diabetic (DM), + KY19382 (DM KY19382), vehicle Vehicle) groups. HDFs HUVECs stimulated under different conditions mice treated...
Danuglipron (PF-06882961), a small-molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R) developed by Pfizer, has shown significant potential to reduce blood glucose levels and weight in patients with type 2 diabetes mellitus. However, it moderate hERG inhibitory activities (IC50 = 4.3 μM), potentially conferring risk for cardiac toxicity. Here, we report new class difluorocyclobutyl derivatives that can be used inhibition caused piperidine ring danuglipron. After vitro vivo...
Whitening cosmetics have a large market scale and broad development prospects, while whitening products of traditional Chinese medicine always been research hotspot. In this study, the active extract Platycodon grandiflorum (PGE) was isolated purified for first time, activity mechanism chemical composition PGE were elucidated. A total 45 components identified via high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis, including arbutin, syringin, chlorogenic acid,...
Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied with itchy and scaly rash. Compound traditional Chinese medicine ointment (CTCMDO) consists of mixture extracts from five plants, which had been used in AD treatment due to good anti-inflammatory anti-allergic effects.In this study, high-performance liquid chromatography (HPLC) chromatography/mass spectrometer (LC/MS) were performed analyze the active ingredients CTCMDO detail establish its HPLC fingerprint....
We investigated the structural properties, foaming capacity and stability, antioxidant activity, amino acid composition of Kudzu protein (KP) hydrolysate (KPH). The peptide sequence KPH was analyzed using ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS), binding ability to Keap1 predicted through molecular docking simulations. electrophoresis weight distribution analysis results showed that significantly lower than KP, with a mean approximately 2000-5000 Da....
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We determined and analyzed the structural, physicochemical functional properties of Semen Ziziphi Spinosae protein. It shows that SZSP has good processing can become a new plant protein source.
Abstract Wild jujube seed protein (WJSP) as one kind of functional food material has attracted much attention due to its highly nutritive and medicinal value in anti‐inflammatory improving immunomodulatory ability. However, owing large molecular weight complex structure, biological activities WJSP were greatly limited cannot be fully utilized by the human body. Therefore, how improve bioavailability develop promising nutritious materials is a great challenge. In this work, wild hydrolysates...
The glycoprotein from Schisandra chinensis was obtained with alkali extraction and acid precipitation, purified DEAE Sepharose Fast Flow Superdex G-75 column. molecular composition structure antifatigue activities of were studied. SCGP's weight approximately 10 KDa, it consisted a carbohydrate component (52.94%) protein (47.06%). SCGP comprised mannose, galactoside, rhamnose, glucose, galactose, xylose, arabinose, fucose, its molar ratio 2.14 : 1.43 1.59 8.17 8.99 3.18 18.51 1, contained 16...
Filipendula palmata (Pall.) Maxim. remains unexplored and underutilized resources with a high potential to improve human health. In this study, new ursane-type triterpenoid, namely, 2α, 3β-dihydroxyurs-12-en-28-aldehyde (compound 10), other 23 known compounds were isolated. 5 triterpenoids (compounds 6, 8, 10–12), 11 flavonoids 13–15 17–24), 6 phenolic 1, 2, 4, 5, 9, 16), 2 sterols 3 7) isolated from the aqueous solution extract of aerial parts F. palmata. The structures all elucidated by...
Potato tubers tend to sprout during long-term storage, resulting in quality deterioration and shortened shelf life. Restrictions on the use of chlorpropham, major potato suppressant, have led a need seek alternative methods. In this study, effects methyl jasmonate (MeJA) solutions MeJA microcapsules sprouting other key attributes tuber were investigated. The results showed that solution was most effective at 300 μmol L−1 according TOPSIS analysis. To prepare microcapsules, optimal...
Abstract Semen Ziziphi Spinosae protein (SZSP) is a new plant resource with good food functional properties and health care function. However, the biological activity of SZSP has not been further studied, which greatly limits development utilization in industry. The aim this study was to investigate protective effect on immunosuppressed mice its inhibitory immune-stimulated RAW264.7 cells. results demonstrated that remarkably improved immunomodulatory secretion serum (interleukin-2, tumor...
To study the flavonoids of Erigeron canadensis.The constituents EtOH extraction from whole plant E. canadensis were isolated and purified by repeated column chromatography. These compounds identified their physical spectral data.Twelve as quercetin-7-O-beta-D-galactopyranoside(1),quercetin(2), luteolin(3), apigenin(4),5,7,4'-trihydroxy-3'-methoxy flavone(5), quercetin-3-alpha-rhamnopyranoside(6), quercetin-3-O-beta-D-glucopyranoside(7), apigenin-7-O-beta-D-glucopyranoside(8),...
Background and Purpose: Polysaccharides from Panax ginseng C. A. Meyer (P. ginseng) are the main active component exhibit significant intestinal anti-inflammatory activity. However, unclear therapeutic mechanism of polysaccharide hinders application for medicine or functional food. Experimental Approach: In this study, a was isolated P. (GP). The primary structure morphology GP were studied by HPLC, FT-IR spectra, scanning electron microscopy (SEM). Further, its activity function evaluated...