A5101891562- Liquid Crystal Research Advancements
- Molecular spectroscopy and chirality
- Surfactants and Colloidal Systems
- Genomics and Phylogenetic Studies
- Synthesis and properties of polymers
- Transportation Planning and Optimization
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Chemical Synthesis and Reactions
- Traffic control and management
- Ginger and Zingiberaceae research
- Economic and Environmental Valuation
- Phytochemistry and Biological Activities
- Spectroscopy and Quantum Chemical Studies
- Metal and Thin Film Mechanics
- Urban Transport and Accessibility
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Antioxidant Activity and Oxidative Stress
- Berberine and alkaloids research
- Pressure Ulcer Prevention and Management
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Plant-derived Lignans Synthesis and Bioactivity
Zhejiang Ocean University
2023-2025
Zhejiang University
2017-2025
Xiangnan University
2024
Amazon (United States)
2024
Hunan University
2024
Nanjing University of Chinese Medicine
2023
Mayo Clinic in Arizona
2022
University of Chinese Academy of Sciences
2022
Institute of Modern Physics
2022
Chinese Academy of Sciences
2022
Danuglipron (PF-06882961), a small-molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R) developed by Pfizer, has shown significant potential to reduce blood glucose levels and weight in patients with type 2 diabetes mellitus. However, it moderate hERG inhibitory activities (IC50 = 4.3 μM), potentially conferring risk for cardiac toxicity. Here, we report new class difluorocyclobutyl derivatives that can be used inhibition caused piperidine ring danuglipron. After vitro vivo...
Based on the structure of caerulomycin A, 90 novel bipyridine derivatives were designed and synthesized. Among these, compound B19 exerted strong antitumor effects in vivo vitro. Importantly, NOP2/Sun RNA methyltransferase 3 (NSUN3) protein was identified as target specific binding to B19, which inhibits oxidative phosphorylation mitochondrial energy metabolism enhances glycolytic activity by NSUN3. Knockdown NSUN3 inhibited both proliferation migration colorectal cancer (CRC) cells...
New cholesteric liquid crystals induced by intermolecular hydrogen bonding between 3-cholesteryloxycarbonylpropanoic acid (MCB) and 4-(4-alkoxybenzoyloxy)-4-stilbazoles (n SZ); MCB N -(4-pyridylmethylidiene)anilines -PMA) were prepared. Their crystalline properties investigated DSC, polarized optical microscopy X-ray diffraction. Cholesteric smectic phases observed. In order to study the influence of covalent non-covalent upon crystal behaviour several new covalently bonded...
Abstract Carotenoids consist of a series conjugated isoprene units that are characteristically highly through double bonds, leading to the formation many isomers susceptible oxidation and other chemical modifications. Extreme hydrophobicity high complexity make carotenoids difficult identify quantify. We implemented use common Syncronis C18 column with strong eluting solvent, here isopropanol, successfully separate mixture 23 standards different structural properties. In addition, method...
NIMA-related kinase 2 (Nek2) plays a significant role in cell cycle regulation, and overexpression of Nek2 has been observed several types carcinoma, suggesting it is potential target for cancer therapy. In this study, we attempted to gain more insight into the binding mechanisms series aminopyrazine inhibitors through multiple molecular modeling techniques, including docking, dynamics (MD) simulations free energy calculations. The simulation results showed that induced fit docking ensemble...
Abstract Five new chiral liquid crystal systems induced by intermolecular hydrogen bonding between 4-[(s)-2-chloro-3-methyl]butyroyloxy-4′-stilbazole (MBSB, proton acceptor) and 4-alkoxybenzoic acids (nBA, donors) were prepared. Their crystalline properties investigated DSC polarized optical microscopy. Chiral nematic smectic phases observed, the thermal stability of one complex was studied through temperature dependent infrared spectroscopy.
Purpose: Sinomenine hydrochloride (SH) is used to treat chronic inflammatory diseases such as rheumatoid arthritis and may also be efficacious against Immunoglobulin A nephropathy (IgAN).However, no trial has investigated the molecular mechanism of SH on IgAN.Therefore, this study aims investigate effect IgAN.Methods: The pathological changes IgA C3 depositions in kidney an IgAN rat model were detected by periodic acid-Schiff (PAS) direct immunofluorescence staining.After extracting T B...
Nine new compounds, including streptothiomycin A-E (1-5), two cyclopentenones (6, 7), one α-pyrone (8), wailupemycin Q (20), along with sixteen known compounds were identified from a rhizosphere strain Streptomyces sp. DS-27 derived the marine cordgrass Spartina alterniflora under different culture conditions. All of structures elucidated by extensive analysis 1D/2D NMR and HR-ESI-MS data. The absolute configurations determined NOESY analysis, ECD, specific rotation GIAO calculations, DP4+...
Abstract New liquid crystals induced by intermolecular hydrogen bonding between 4-[3, 4, 5-tridocyloxy benzoyloxy)-4′-stilbazole (3DBSZ) and malonic acid, succinic glutaric adipic pimelic suberic maleic fumaric 3,4,5,-tridocyloxy-benzoic acid(3DBA) respectively were prepared, their crystalline properties investigated using DSC, polarized optical microscopy wide-angle X-ray diffraction. The results show that most of the complexes exhibit column phases. Furthermore, a new room temperature...
Abstract A new series of chiral Schiff's bases containing 2-hydroxybenzilideneaniline moieties and their copper complexes were synthesized studied by differential scanning calorimetry, polarized optical microscopy, X-ray diffraction EPR measurement. The results show that most the only two exhibited smectic liquid crystal phases.
Abstract The synthesis of three new series chiral Schiff's bases containing benzilideneaniline and 2-hydroxybenzilideneaniline moieties as mesogenic cores is presented. Differential scanning calorimetry, optical polarizing microscopy X-ray diffraction measurements were used to study the phase transition temperatures behaviour. results reveal that most these materials show smectic mesomorphism.
A series of liquid crystalline copolymers, poly{2-hydroxyethyl methacrylate}-co-{6-[4-(S2-methyl-l-butyloxycarbonylphenylazo)phenoxy]hexyl methacrylate} with an azobenzene moiety as photoreactive mesogenic unit, was prepared and investigated by using DSC, polarized optical microscopy X-ray diffraction. The results show that these polymers exhibit smectic phases. Z-type Langmuir-Blodgett films copolymers were successfully deposited onto calcium fluoride quartz. Reversible homeotropic planar...
Alpiniamides E-G, three previously unreported linear polyketide derivatives, along with two known compounds, were isolated from Streptomyces sp. QHA48, which was the saline lakes of Qinghai-Tibet Plateau. The structures these compounds determined through analysis their spectroscopic data, as well density functional theory prediction NMR chemical shifts, application DP4+ algorithm and electronic circular dichroism (ECD) calculations. In a cell-based lipid-lowering assay, all five alpiniamides...
To summarize the best evidence of prevention strategies for pressure injury in adult hospitalized burn patients.
Two novel di-tert-butyl-type structures (1-2), and five known compounds (3-7) were isolated from the chemical investigations of a saline lake actinomycete, Streptomyces sp. XZB42. The new elucidated by extensive NMR spectroscopic analysis, HRESIMS data, GIAO (gauge-including atomic orbitals) specific optical rotation (SOR).
Dietary Guidelines for Chinese Residents (2022) states more than half (50.7%) of adult residents are overweight or obese. In global term, about 1.3 million people die in the world annually due to obesity and its complications. With increasing number weight-watcher, various ways lose weight emerge an endless stream. However, this hot-debated loss diet scientific not? This paper evaluates efficacy safety ketogenic through literature researches. Results show that Ketogenic (KD) is quite...
Abstract Previous studies have found that the prevalence of subtypes T cells may be associated with patient outcomes, but a comprehensive analysis immune profile in TM FL has not been done. In present study, we identified groups patients discretely unique TMEs and determined whether T-cell phenotypes TME differed among groups. Using cohort 82 biopsy specimens collected before treatment, defined type based on content major lineages (T, B, monocytes/macrophages NK cells) by CyTOF analysis....
A series of liquid crystalline binary polymer blends consisting P1 with a dimethylamino group as an electron donor and P2 nitro acceptor was prepared investigated by using DSC, optical polarized microscopy x-ray diffraction. The mixtures their model compounds 4-hexyloxy-4'-nitro-azobenzene (MA) 4-hexyloxybenzylidene-4'-(N,N-dimethylamino)-aniline (MD) were also investigated. results show that these have good miscibility exhibit broader mesophase ranges than the individual donor, which are...