A5025979498- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Temporomandibular Joint Disorders
- Drug Transport and Resistance Mechanisms
- Transcranial Magnetic Stimulation Studies
- HER2/EGFR in Cancer Research
- Pharmacological Effects and Toxicity Studies
- Orthodontics and Dentofacial Orthopedics
- Lymphoma Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Epilepsy research and treatment
- Biosimilars and Bioanalytical Methods
- Chronic Myeloid Leukemia Treatments
- Wound Healing and Treatments
- Circadian rhythm and melatonin
- Immunotherapy and Immune Responses
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Skin Protection and Aging
- Regulation of Appetite and Obesity
- Autoimmune Bullous Skin Diseases
- bioluminescence and chemiluminescence research
- Cellular Mechanics and Interactions
- Muscle metabolism and nutrition
- Laser Applications in Dentistry and Medicine
Astellas Pharma (Japan)
2019-2021
Massachusetts General Hospital
2017-2018
Kindai University
2017
Tokyo Medical and Dental University
2010-2014
Kyoto Pharmaceutical University
2012-2014
Kyoto University
1978-2014
RIKEN Center for Computational Science
2010
ABSTRACT The purpose of this study was to develop an ultra‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method 22 antiepileptics for routine therapeutic monitoring. used in the analyses were carbamazepine, carbamazepine‐10,11‐epoxide, clobazam, N ‐desmethylclobazam, clonazepam, diazepam, ‐desmethyldiazepam, ethosuximide, felbamate, gabapentin, lamotrigine, levetiracetam, ‐desmethylmesuximide, nitrazepam, phenobarbital, phenytoin, primidone, tiagabine, topiramate,...
The distribution of the indoleamine 2,3-dioxygenase activity was investigated in various parts rabbit brain using supernatant fraction (30,000 X g, 30 min) homogenates. A low but significant detected all brain. highest associated with pineal gland and choroid plexus. Specific activities fractions derived from plexus were 84.8 34.2 pmol/h/mg protein at 37 degrees C, respectively, L-tryptophan as substrate. When cultured L-[methylene-14C]tryptophan, L-[methylene-14C]kynurenine formed by action...
Abstract Brief exposure of skin to near-infrared (NIR) laser light has been shown augment the immune response intradermal vaccination and thus act as an immunologic adjuvant. Although evidence indicates that NIR adjuvant capacity activate innate subsets including dendritic cells (DCs) in conventional adjuvants do, precise immunological mechanism by which acts is largely unknown. In this study we sought identify cellular target using established mouse model influenza examining alteration...
Abstract The treatment of skin with a low-power continuous-wave (CW) near-infrared (NIR) laser prior to vaccination is an emerging strategy augment the immune response intradermal vaccine, potentially substituting for chemical adjuvant, which has been linked adverse effects vaccines. This approach proved be low cost, simple, small, and readily translatable compared previously explored pulsed-wave medical lasers. However, little known on mode laser–tissue interaction eliciting adjuvant...
Background and Objectives: Diclofenac (DIC) is metabolized to reactive metabolites such as diclofenac acyl-β-d-glucuronide (DIC-AG). It possible that could cause tissue damage by formation of covalent protein adducts other modification cellular proteins or induction immune responses against its adducts. However, the detailed mechanisms idiosyncratic drug-induced liver injury (DILI) have been unclear. The objective clarify involvement DIC-AG 4′hydroxydiclofenac (4′OH-DIC) in acute DILI....
Peficitinib is an oral pan-Janus kinase inhibitor for the treatment of rheumatoid arthritis. Co-administration peficitinib with metformin, a type 2 diabetes therapy, can occur in clinical practice. Hepatic and renal uptake metformin mediated by organic cation transporter 1 (OCT1) OCT2, respectively, its excretion multidrug toxin extrusion (MATE1) MATE2-K. This study investigated effect on pharmacokinetics vitro healthy volunteers.Inhibitory effects metabolite H2 into human OCT1/2-...
To investigate the effects of an experimentally-induced increase in occlusal vertical dimension (iOVD) on functional characteristics temporomandibular joint (TMJ) mechanoreceptors rats.Sixty 13-week-old male albino Wistar rats were divided into control and iOVD groups (30 animals each). The between maxillary mandibular molars group was increased by 2.0 mm with a build-up resin molars. Single-unit activities TMJ evoked passive jaw movement. Recording performed from gasserian ganglion 1 day 1,...
This study measured and compared the exposure safety of peficitinib (ASP015K), a novel oral Janus kinase inhibitor, in subjects with normal impaired renal function after single oral, clinically relevant dose.This was an open-label, parallel-group conducted at two centres Japan. Subjects mildly, moderately, or severely received dose (one 150 mg tablet) under fasting conditions hospital setting. Blood samples were collected prior to administration up 72 h post-dose for pharmacokinetic...
To analyse the population pharmacokinetics (PK) of peficitinib in patients with rheumatoid arthritis (RA) and assess potential PK covariates to identify requirement for dose adjustment RA patients.The analysis incorporated 2464 observations from 98 healthy volunteers 4919 989 patients. A model was constructed by a nonlinear mixed effect using NONMEM prior information volunteer model.A 2-compartment sequential zero- first-order absorption lag time Covariate exploration patient revealed that...
To investigate whether low mechanical loading on the temporomandibular joint (TMJ) when ingesting a liquid diet affects response properties of neurons in trigeminal spinal tract subnucleus caudalis (Sp5C) growing rats.Shortly after weaning, 2-week-old male rats were fed chow pellets (control) or (experimental). Firing activities single sensory units recorded from Sp5C at 4, 5, 7, and 9 weeks. Neurons functionally classified by their responsiveness to TMJ stimuli. The responses Class II III...
Peficitinib pharmacokinetics and pharmacodynamics have been characterized mainly in Caucasian subjects. This study investigated the pharmacokinetics, pharmacodynamics, safety, tolerability of peficitinib healthy Japanese subjects compared with In this single-center, randomized, double-blind, placebo-controlled study, a cohort (n = 24) men received single oral dose (20, 60, or 200 mg) placebo. Another (10, 30, 100 placebo twice daily for 7 days. Pharmacokinetic pharmacodynamic parameters were...
Abstract The marketed tablet formulation of peficitinib differs from the used during clinical trials. bioequivalence and developmental tablet, food effect on formulation, were analyzed in 2 Japanese open‐label, randomized, 2‐way crossover studies healthy male volunteers. Volunteers received a single oral dose 150‐mg under fasted conditions (bioequivalence), fed or (food effect). Bioequivalence was compared with tablet. Samples for pharmacokinetic analysis collected before ≤72 hours after...
Abstract The aim was to analyze the relationship between peficitinib exposure and efficacy response according American College of Rheumatology (ACR) 20 criteria 28‐joint disease activity score based on C‐reactive protein (DAS28‐CRP) in rheumatoid arthritis (RA) patients, identify relevant covariates by developing exposure–response models. analysis incorporated results from three multicenter, placebo‐controlled, double‐blind studies. As an parameter, individual post hoc pharmacokinetic (PK)...
Recently, it has been shown that prolonged feeding of a liquid diet after being weaned impedes the functional development and leads to immature mastication in growing rats. Since jaw muscle spindles play an important role control movement during normal masticatory function, this study we investigated effects on jaw-closing Soon weaning, 40 female Wistar rats were divided into two equal groups. The group was fed solid experimental diet. At 5, 7, 9 11 weeks, anesthetized response masseter...
<h3>Background</h3> Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, was shown to be efficacious as once-daily therapy for moderate-to-severe rheumatoid arthritis (RA) in phase 2b study (NCT01649999)<sup>1</sup> and two 3 studies (NCT02308163<sup>2</sup> NCT02305849).<sup>3</sup> Mean urinary excretion of peficitinib accounted 9–15% the dose.<sup>4</sup> <h3>Objectives</h3> To assess pharmacokinetics (PK) safety single, dose 150 mg subjects with normal impaired renal function....