A5036380512- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Genetic and Kidney Cyst Diseases
- Bipolar Disorder and Treatment
- Tracheal and airway disorders
- Child and Adolescent Psychosocial and Emotional Development
- Cancer, Hypoxia, and Metabolism
- Emergency and Acute Care Studies
- Diabetes Treatment and Management
- Obstructive Sleep Apnea Research
- COVID-19 and healthcare impacts
- Family and Patient Care in Intensive Care Units
- Congenital Diaphragmatic Hernia Studies
- Sleep and related disorders
- Microplastics and Plastic Pollution
- MRI in cancer diagnosis
- Tryptophan and brain disorders
- Medical and Biological Sciences
- African history and culture analysis
- Hemispheric Asymmetry in Neuroscience
- Digital Mental Health Interventions
- Microtubule and mitosis dynamics
- Global Maritime and Colonial Histories
- Recycling and Waste Management Techniques
University of Oxford
2021-2024
John Radcliffe Hospital
2021-2022
Mary Lyon Centre at MRC Harwell
2018-2021
Oxford Fertility
2018
SUNY Fredonia
2013
York University
2013
Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory molecular machine cilia, axoneme, and have luminal surfaces patterned periodically by microtubule inner proteins (MIPs). Here we present an atomic model 48-nm repeat a mammalian DMT, derived from cryoelectron microscopy (cryo-EM) map complex isolated bovine respiratory cilia. The structure uncovers principles organization features specific to vertebrate including previously unknown MIPs, bundle tektin...
The COVID-19 pandemic changed continuous positive airway pressure (CPAP) setup pathways. We evaluated patients commenced on CPAP in 2019 (prepandemic) and 2020 (post-first UK wave). Face-to-face (F2F) numbers, with turned on, decreased from 613 (98.9%) 2019, to 6 (1.1%) 2020. In 2020, setups were F2F without (403 (71.1%)), or remote (158 (27.9%)). Prepandemic median usage at first follow-up was 5.4 (2.7–6.9) hours/night fell by 0.9 (95% CI 0.5 1.2, p<0.0001) found clinically relevant...
Primary ciliary dyskinesia (PCD) is a chronic suppurative airways disease that usually recessively inherited and has marked clinical phenotypic heterogeneity. Classic symptoms include neonatal respiratory distress, rhinitis since early childhood, otitis media, recurrent airway infections leading to bronchiectasis, sinusitis, laterality defects with without congenital heart including abnormal situs in approximately 50% of the cases, male infertility. Lung function deteriorates progressively...
Cystic fibrosis (CF) is an autosomal recessive condition that primarily manifests as a chronic respiratory disease. CF usually diagnosed in early childhood or through newborn screening although small but important group, diagnosis not made until adulthood. Highly effective cystic transmembrane conductance regulator (CFTR) modulator therapies are now available for most genetic causes of highlighting the importance identifying people with late presentations CF.We aimed to identify clinical...
Background: Infectious respiratory disease in children provides a significant seasonal workload burden to paediatric emergency departments. Studies from the Southern hemisphere during first wave of COVID-19 had shown decrease infections. During pandemic, predicted drops infectious circulating led redeployment junior doctors services adult services. Methods: We extracted data on presenting tertiary department with illness, comparing winter 2019-2020 (pre-COVID-19) 2020-2021 (post-COVID-19)....
Von Hippel Lindau (VHL) syndrome is an inherited condition that associated with retinal and central nervous system haemangioblastomas, as well renal pancreatic cysts (Varshney et al., 2017). The have a significant likelihood of neoplastic change, act pre-malignant pathological finding prior to the development clear cell carcinoma.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)