A5073471585- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Adenosine and Purinergic Signaling
- HIV-related health complications and treatments
- Cystic Fibrosis Research Advances
- HIV/AIDS drug development and treatment
- Venous Thromboembolism Diagnosis and Management
- Vibrio bacteria research studies
- Respiratory Support and Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
- Infectious Encephalopathies and Encephalitis
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Epilepsy research and treatment
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Advanced Proteomics Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Pharmacological Receptor Mechanisms and Effects
- HIV/AIDS Research and Interventions
- Coronary Artery Anomalies
- Long-Term Effects of COVID-19
Johns Hopkins University
2023-2024
University Hospital Southampton NHS Foundation Trust
2018-2024
Johns Hopkins Medicine
2023-2024
University of North Carolina at Chapel Hill
2018-2022
Hospital Universitari Germans Trias i Pujol
2020
Universidad Católica San Antonio de Murcia
2020
Universitat Autònoma de Barcelona
2020
UNC Lineberger Comprehensive Cancer Center
2018
Lycera (United States)
2018
NYU Langone Health
2018
Appropriate interactions between antiretroviral therapies (ART) and drug transporters metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of achieve HIV suppression. These proteins modulated by demographic lifestyle factors, including substance use. While understudied, illicit substances share transport metabolism pathways with ART, increasing potential for adverse drug:drug interactions. This is particularly important when considering as it...
The latent reservoir for HIV-1 in resting CD4+ T cells persists despite antiretroviral therapy as a barrier to cure. antigen-driven proliferation of infected is major mechanism persistence. However, activation through the cell antigen receptor (TCR) can induce proviruses, leading viral cytopathic effects and immune clearance. In single-cell studies, we show that, relative uninfected or with defective provirus, an intact provirus have profound proliferative defect response TCR stimulation....
The type VI secretion system (T6SS) is widely distributed in diverse bacterial species and habitats where it required for interbacterial competition interactions with eukaryotic cells. Previous work described the role of a T6SS beneficial symbiont, Vibrio fischeri, during colonization light organ Euprymna scolopes squid. However, prevalence diversity T6SSs found within distinct symbiotic structures this model host have not yet been determined. Here, we analyzed 73 genomes isolates from squid...
Primary ciliary dyskinesia (PCD) is a chronic suppurative airways disease that usually recessively inherited and has marked clinical phenotypic heterogeneity. Classic symptoms include neonatal respiratory distress, rhinitis since early childhood, otitis media, recurrent airway infections leading to bronchiectasis, sinusitis, laterality defects with without congenital heart including abnormal situs in approximately 50% of the cases, male infertility. Lung function deteriorates progressively...
Human immunodeficiency virus (HIV) infection continues to promote neurocognitive impairment, mood disorders, and brain atrophy, even in the modern era of viral suppression. Brain lipids are vulnerable HIV-associated energetic strain may contribute neurologic dysfunction due alterations lipid breakdown structural composition. HIV neuropathology is region dependent, yet there has not been comprehensive characterization spatial heterogeneity during that possibly impacts function. To address...
<b>Abstract ID 93889</b> <b>Poster Board 429</b> Neurologic deficits associated with human immunodeficiency virus (HIV) infection demonstrate the need to eliminate viral reservoirs in brain antiretroviral therapy (ART). First-line ART drugs are substrates of transporters at blood barrier (BBB), including MRP4, BCRP, and P-gp as well nucleoside kinase drug metabolizing enzymes, such creatine kinase-brain type, adenylate 2, pyruvate kinase, deoxycytidine phosphoglycerate 1, cytidine/uridine...
<b>Abstract ID 101166</b> <b>Poster Board 532</b> Appropriate interactions between antiretroviral therapies (ART) and drug transporters metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of achieve HIV suppression. These proteins modulated by demographic lifestyle factors, including substance use. While understudied, illicit substances share transport metabolism pathways with ART, increasing potential for adverse drug:drug interactions. This is...
Summary Therapeutically targeting the brain requires interactions with endothelial cells, pericytes, and astrocytes at blood barrier (BBB). We evaluated regional cell-type specific drug metabolism transport mechanisms using rhesus macaques in vitro treatment of primary human cells. Here, we report heterogenous distribution representative drugs, tenofovir (TFV), emtricitabine (FTC), their active metabolites, which cerebrospinal fluid measures could not reflect. found that all BBB cell types...
Background Many adolescents with asthma have dysfunctional breathing and poor quality of life. Breathing retraining is recommended for symptom management efficiency. This trial evaluated the feasibility conducting a definitive to evaluate effectiveness cost-effectiveness digital intervention (Breathe4T – mobile-friendly website). Specifically, recruitment, follow-up response rates, acceptability uptake measures, as well agreement between two life questionnaires were measured. Methods...
The blood brain barrier (BBB) represents a significant obstacle in drug penetration that challenges efforts the treatment of neurological disorders. Therapeutically targeting requires interactions with each BBB cell type, including endothelial cells, pericytes, and astrocytes. Yet, relative contribution these types to mechanisms facilitate disposition is not well characterized. Here, we use first-line antiretroviral therapies, tenofovir (TFV) emtricitabine (FTC), as models investigate...
ABSTRACT Background Appropriate interactions between antiretroviral therapies (ART) and drug transporters metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of achieve HIV suppression. These proteins modulated by demographic lifestyle factors, including substance use. While understudied, illicit substances share transport metabolism pathways with ART, increasing potential for adverse drug:drug interactions. This is particularly important when...
ABSTRACT Human immunodeficiency virus (HIV) infection continues to promote neurocognitive impairment, mood disorders, and brain atrophy even in the modern era of viral suppression. Brain lipids are vulnerable HIV-associated energetic strain contribute neurologic dysfunction due alterations lipid breakdown structural composition. HIV neuropathology is region dependent, yet there has not been comprehensive characterization spatial heterogeneity during that may impact function. To address this...