A5051612896- Genetic factors in colorectal cancer
- Digestive system and related health
- Blood disorders and treatments
- Viral gastroenteritis research and epidemiology
- Vitamin D Research Studies
- Clinical Nutrition and Gastroenterology
- Cancer Cells and Metastasis
- Gut microbiota and health
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- TGF-β signaling in diseases
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Barrier Structure and Function Studies
- Neuroblastoma Research and Treatments
- Celiac Disease Research and Management
- Geological Modeling and Analysis
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Cholinesterase and Neurodegenerative Diseases
- Histone Deacetylase Inhibitors Research
- Biochemical effects in animals
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
Baylor College of Medicine
2015-2022
The University of Texas Health Science Center at Houston
2019
The University of Texas at Austin
2015
Current therapy for Alzheimer's disease (AD) focuses on delaying progression, illustrating the need more effective therapeutic targets. Histone deacetylase 6 (HDAC6) modulates tubulin acetylation and has been implicated as an attractive target. HDAC6 is also elevated in postmortem tissue samples from patients. However, inhibitors have had limited success preclinically due to low blood-brain barrier penetration.We investigated a specific, potent inhibitor (ACY-738) mouse model of AD. We...
Abstract Colorectal cancer is the third most common and leading cause of death in United States. Growth factor–independent 1 (GFI1) a zinc finger transcriptional repressor responsible for controlling secretory cell differentiation small intestine colon. GFI1 plays significant role development human malignancies, including leukemia, lung cancer, prostate cancer. However, colorectal progression largely unknown. Our results demonstrate that RNA protein expression are reduced advanced-stage...
Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of human epithelium. Here, we explored effect on transcriptome common variations in culture methods, including extracellular matrix substrate, format, segment, differentiation status, patient heterogeneity. RNA-sequencing datasets from 276 experiments performed 37 enteroid colonoid lines 29 patients were aggregated several groups Texas Medical Center. DESeq2 gene set...
Enteroaggregative Escherichia coli (EAEC) is a significant cause of acute and chronic diarrhea, foodborne outbreaks, infections the immunocompromised, growth stunting in children developing nations. There no vaccine resistance to antibiotics rising. Unlike related E. pathotypes that are often associated with bouts infection, EAEC persistent diarrhea subclinical long-term colonization. Several secreted virulence factors have been pathogenesis linked disease humans, less certain molecular...
Although vitamin D is critical for the function of intestine, most studies have focused on duodenum. We show that transgenic expression receptor (VDR) only in distal intestine VDR null mice (KO/TG mice) results normalization serum calcium and rescue rickets. it had been suggested transport involves a paracellular process, we found 1,25-dihydroxyvitamin
Abstract Background Inflammatory bowel diseases (IBDs) comprise a heterogenous group of chronic gastrointestinal disorders that are multifactorial in etiology. Experimental vitro and vivo studies suggest intestinal vitamin D receptor (VDR) signaling plays role modulating the immune response IBD as cause and/or consequence inflammation. Aim The aim this study is to associations between gene single nucleotide polymorphisms(SNPs), levels, endoscopic disease activity IBD. Methods This...
Abstract Calcium phosphate‐based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects in procedures such as percutaneous vertebroplasty. With a view to use low load bearing applications sinus augmentation or filling extraction sites. However, inclusion certain species into cement formulations has diminish mechanical properties and thereby reduce their prospects clinical translation. Consequently, we have prepared α‐tricalcium phosphate...
Abstract Background & Aims Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of epithelium. Here, we explored effect on transcriptome common variations in culture methods, including extracellular matrix substrate, format, segment, differentiation status, patient heterogeneity. Methods RNA-sequencing datasets from 251 experiments performed 35 human enteroid colonoid lines 28 patients were aggregated several groups...
Background: Oxidative stress has been implicated in metabolic syndrome (MetS); however, antioxidants such as vitamin E have had limited success the clinic. This prompts question of what effects amore potent antioxidant might produce. A prime candidate is recently developed bioengineered antioxidant, poly(ethylene glycol)-functionalizedhydrophilic carbon clusters (PEG-HCCs), which are capable neutralizing reactive oxygen species (ROS) superoxide anion and hydroxyl radical at106/molecule...
<p>Supplementary Figure 1. Specificity of GFI1 antibody. Supplementary 2. Cell cycle and apoptosis analysis GFI1-expressing CRC cancer cell lines in vitro. 3. Expression CDX2 the intestine. 4. Loss Gfi1 affects secretory lineages.</p>
<p>Supplementary Figure 1. Specificity of GFI1 antibody. Supplementary 2. Cell cycle and apoptosis analysis GFI1-expressing CRC cancer cell lines in vitro. 3. Expression CDX2 the intestine. 4. Loss Gfi1 affects secretory lineages.</p>
<div>Abstract<p>Colorectal cancer is the third most common and leading cause of death in United States. Growth factor–independent 1 (GFI1) a zinc finger transcriptional repressor responsible for controlling secretory cell differentiation small intestine colon. GFI1 plays significant role development human malignancies, including leukemia, lung cancer, prostate cancer. However, colorectal progression largely unknown. Our results demonstrate that RNA protein expression are reduced...
<div>Abstract<p>Colorectal cancer is the third most common and leading cause of death in United States. Growth factor–independent 1 (GFI1) a zinc finger transcriptional repressor responsible for controlling secretory cell differentiation small intestine colon. GFI1 plays significant role development human malignancies, including leukemia, lung cancer, prostate cancer. However, colorectal progression largely unknown. Our results demonstrate that RNA protein expression are reduced...
Abstract Colorectal cancer (CRC) is the third most common and leading cause of death in United States, causing about 50,000 deaths each year. Growth Factor-Independent 1 (GFI1) a critical zinc finger transcriptional repressor responsible for controlling secretory cell differentiation small intestine colon. GFI1 plays significant role development human malignancies, including leukemia, lung prostate cancer. However, CRC progression largely unknown. Our results demonstrate that RNA protein...
Abstract Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the intestine that affect children and adults. The etiology is multifactorial with contribution genetic, immune, microbial, environmental risk factors a substantial involvement host:microbial cross-talk in lumen. Whether how antiviral responses contribute to IBD pathogenesis under intense investigation. Here, we identified two unrelated patients diagnosed very early onset (VEOIBD) rare variants type III...
Human intestinal enteroids (HIE) models have contributed significantly to our understanding of diarrheal diseases and other infections, but their routine culture conditions fail mimic the mechanical environment native wall. Because characteristics intestine alter how pathogens interact with epithelium, we used different concentrations polyethylene glycol (PEG) generate soft (~2 kPa), medium (~10 stiff (~100 kPa) hydrogel biomaterial scaffolds. The height HIEs cultured in monolayers atop...