A5010536792- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Analysis
- Multiferroics and related materials
- Magnetic and transport properties of perovskites and related materials
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Transition Metal Oxide Nanomaterials
- Head and Neck Cancer Studies
- Ferroelectric and Piezoelectric Materials
- Lung Cancer Diagnosis and Treatment
- Catalysis and Oxidation Reactions
- Prostate Cancer Diagnosis and Treatment
- Gas Sensing Nanomaterials and Sensors
- Radiation Therapy and Dosimetry
- Advanced Condensed Matter Physics
- Metallurgical and Alloy Processes
- Brain Tumor Detection and Classification
- Cutaneous Melanoma Detection and Management
- Voice and Speech Disorders
- Chemical and Physical Properties of Materials
- Catalytic Processes in Materials Science
- Endometrial and Cervical Cancer Treatments
- MRI in cancer diagnosis
Henry Ford Health System
2013-2023
Wayne State University
2009-2016
University of Connecticut
2013
To evaluate the clinical potential of deformable image registration (DIR)-based automatic propagation physician-drawn contours from a planning CT to midtreatment images for head and neck (H&N) adaptive radiotherapy.Ten H&N patients, each with (CT1) subsequent (CT2) taken approximately 3-4 week into treatment, were considered retrospectively. Clinically relevant organs targets manually delineated by radiation oncologist on both sets images. Four commercial DIR algorithms, two B-spline-based...
The development of methods to economically synthesize single wire structured multiferroic systems with room temperature spin–charge coupling is expected be important for building next-generation multifunctional devices ultralow power consumption. We demonstrate the fabrication a nanowire system, new geometry, exhibiting magnetodielectric coupling. A coaxial nanotube/nanowire heterostructure barium titanate (BaTiO3, BTO) and cobalt (Co) has been synthesized using template-assisted method....
Purpose: We have quantitatively evaluated the image quality of a new commercially available iterative cone-beam computed tomography reconstruction algorithm over standard results. Methods: This pipeline uses finite element solver (AcurosCTS)-based scatter correction and statistical (iterative) in addition to kernel-based followed by filtered back-projection-based Feldkamp-Davis-Kress reconstruction. Standard full-fan half-rotation Head, half-fan full-rotation Pelvis protocols been...
In this work, the structural, electrical, and magnetic properties of orthorhombic TbMnO3 Tb0.67Ho0.33MnO3 ceramics are presented. The lattice parameters Mn-O-Mn bond angle were found to decrease with Ho-substitution as evidenced by Rietveld refinement X-ray diffraction data Raman spectroscopy measurements. A weak ferromagnetic moment was observed in both dc ac measurements Ho-substituted sample possibly due spin canting antiferromagnetic phase. confirmed be multiferroic appearance...
We have studied the effects of doping magnetic ions on phase transitions in polycrystalline Ni${}_{3}$V${}_{2}$O${}_{8}$ samples using magnetic, dielectric, and specific heat measurements. Substituting spin-1/2 Cu results a larger suppression transition temperatures than observed with spin-3/2 Co. The multiferroic-ordering persists at small concentrations for both Co dopants, this still developing almost 30 at% However, multiferroic-magnetic structure is completely suppressed only 10 Cu. On...
The purpose of this work is to present the results a margin reduction study involving dosimetric and radiobiologic assessment cumulative dose distributions, computed using an image guided adaptive radiotherapy based framework. Eight prostate cancer patients, treated with 7–9, 6 MV, intensity modulated radiation therapy (IMRT) fields, were included in study. workflow consists cone beam CT (CBCT) localization, deformable registration CBCT simulation datasets (SIM-CT), reconstruction...
$\mathrm{FeV}{\mathrm{O}}_{4}$ is a multiferroic that undergoes two antiferromagnetic transitions at ${T}_{\mathrm{N}1}\ensuremath{\sim}21\phantom{\rule{0.28em}{0ex}}\mathrm{K}$ and ${T}_{\mathrm{N}2}\ensuremath{\sim}15\phantom{\rule{0.28em}{0ex}}\mathrm{K}$, with small ferroelectric polarization developing the 15-K transition. We have studied effect of magnetic nonmagnetic transition metal dopants on these phase in order to investigate microscopic mechanisms for magnetoelectric coupling...
To develop standard (SPCA) and regularized (RPCA) principal component analysis models of anatomical changes from daily cone beam CTs (CBCTs) head neck (H&N) patients assess their potential use in adaptive radiation therapy, for extracting quantitative information treatment response assessment.Planning CT images ten H&N were artificially deformed to create "digital phantom" images, which modeled systematic during therapy. Artificial deformations closely mirrored patients' actual interpolated...
The objective of this study was to evaluate the anatomical changes and associated dosimetric consequences pharyngeal constrictor muscles (PCMs) that occur during head neck (H N) radiotherapy (RT).A cohort 13 oropharyngeal cancer patients with daily cone beam computed tomography (CBCT) retrospectively studied. On every 5th CBCT image, PCM manually delineated by a radiation oncologist. anterior-posterior thickness measured at midline level C3 vertebral body. Delivered dose estimated...
We have studied phase transitions in multiferroic Ni3V2O8, through dielectric measurements and by investigating the effects of Zn doping. The divergence constant near T L = 6.4 K can be approximately fit power law behaviour, but exhibits different critical exponents above below . two higher temperature magnetic (Ni1−x x )3V2O8, are strongly suppressed as doping fraction is increased. rates suppression both H with consistent two-dimensional spin systems, Ising spins Heisenberg spins.
To investigate the impact of reducing Clinical Target Volume (CTV) to Planning (PTV) margins on delivered radiation therapy (RT) dose and patient reported quality-of-life (QOL) for patients with localized prostate cancer.
Purpose: One primary limitation of using CBCT images for H' N adaptive radiotherapy (ART) is the limited field view (FOV) range. We propose a method to extrapolate by deformed planning CT dose day calculations. The aim was estimate geometric uncertainty our extrapolation method. Methods: Ten patients, each with (CT1) and subsequent (CT2) taken, were selected. Furthermore, small FOV (CT2short) synthetically created cropping CT2 size image. Then, an extrapolated (CBCTextrp) generated...
Purpose: To estimate the actual delivered dose to organs from CBCT‐based image‐guided radiation therapy for localized prostate cancer treatments. Methods: Seven treatments were retrospectively selected, each with ∼40 CBCT images. All patients treated 9 IMRT beams. The PTV margin was 6 mm in posterior direction, and 10 otherwise around prostate. For patient, original plan used calculate treatment on image at position. calculated daily then warped back planning CT via an intensity‐based...
Purpose: We evaluated the performance of two commercially available and one open source B‐Spline deformable image registration (DIR) algorithms between T2‐weighted MRI treatment planning CT using DICE indices. Methods: simulation (CT‐SIM) MR (MR‐SIM) for four prostate cancer patients were conducted on same day setup immobilization devices. images (120 kVp, 500 mAs, voxel size = 1.1×1.1×3.0 mm3) acquired an open‐bore scanner. Turbo Spine Echo (T2W‐TSE) (TE/TR/α 80/4560 ms/90°, 0.7×0.7×2.5...
Purpose: To evaluate the anatomical changes and associated dosimetric consequences to pharyngeal constrictor (PC) that occurs during head neck radiotherapy (H&N RT). Methods: A cohort of 13 oro-pharyngeal cancer patients, who had daily CBCT's for localization, was retrospectively studied. On every 5th CBCT, PC manually delineated by a radiation oncologist. The anterior-posterior thickness measured at C3 level. Delivered dose estimated calculating doses on CBCT's, accumulating corresponding...
Abstract Purpose We performed quantitative analysis of differences in deformable image registration (DIR) and dose accumulation (DDA) computed on CBCT datasets reconstructed using the standard (Feldkamp‐Davis‐Kress: FDK_CBCT) a novel iterative (iterative_CBCT) reconstruction algorithms. Methods Both FDK_CBCT iterative_CBCT images were for 323 fractions treatment 10 prostate cancer patients. Planning CT deformably registered to each data set. After daily distributions computed, they mapped...
Purpose: Accurate deformable image registration (DIR) between CT and CBCT in H&N is challenging. In this study, we propose a practical hybrid method that uses not only the pixel intensities but also organ physical properties, structure volume of interest (VOI), interactive local registrations. Methods: Five oropharyngeal cancer patients were selected retrospectively. For each patient, planning was registered to last fraction CBCT, where anatomy difference largest. A three step strategy...
Purpose: To compare the performance of two deformable image registration (DIR) algorithms for contour propagation and to evaluate accuracy DIR use with high dose rate (HDR) brachytherapy planning cervical cancer. Methods: Five patients undergoing HDR ring tandem were included in this retrospective study. All underwent CT simulation replanning prior each fraction (3–5 fractions total). CT‐to‐CT was performed using commercially available software platforms: SmartAdapt, Varian Medical Systems...
We report the synthesis and electric properties of nano-crystalline Tb 1− x Y MnO 3 ( = 0, 0.1, 0.2, 0.3 0.4) compounds prepared by gel-combustion method. These samples were characterized a number techniques including X-ray diffraction (XRD), Raman spectroscopy, specific-heat measurement, neutron diffraction, magnetic field dependent pyrocurrent measurement. All crystallize in orthorhombic structure with space group Pnma at room temperature. Anomalies observed low temperature measurement...