A5101438561- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Uterine Myomas and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemoglobinopathies and Related Disorders
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
- Cancer-related molecular mechanisms research
- Neonatal Health and Biochemistry
- Blood transfusion and management
- Iron Metabolism and Disorders
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Blood groups and transfusion
- Hemoglobin structure and function
- Dental Implant Techniques and Outcomes
- Vitamin K Research Studies
- Dental materials and restorations
- Virus-based gene therapy research
- Blood properties and coagulation
- Sports injuries and prevention
- Cancer Research and Treatments
- Vitamin D Research Studies
- Dental Health and Care Utilization
Delhi Pharmaceutical Science and Research University
2021-2024
Koç University
2022
Marmara University
2022
University of Alabama at Birmingham
2022
University of Michigan–Ann Arbor
2022
Hemophilia Center of Western Pennsylvania
2016-2020
Women & Children's Hospital of Buffalo
2015-2020
Devi Ahilya Vishwavidyalaya
2020
University at Buffalo, State University of New York
2018-2020
MDS Associates (United States)
2020
Rationale: A major abnormality that characterizes the red cell "storage lesion" is increased hemolysis and reduced lifespan after infusion. Low levels of intravascular transfusion aged stored cells disrupt nitric oxide (NO) bioavailabity, via accelerated NO scavenging reaction with cell-free plasma hemoglobin. The degree post-transfusion effects on endothelial-dependent vasodilation responses to acetylcholine have not been fully characterized in humans.Objectives: To evaluate blood limits...
Abstract Blood clotting at the vascular injury site is a complex process that involves platelet adhesion and clot stiffening/contraction in milieu of fluid flow. An integrated understanding hemodynamics tissue mechanics regulating this currently lacking due to absence an experimental system can simultaneously model formation measure under shear Here we develop microfluidic-integrated microclot-array-elastometry (clotMAT) recapitulates dynamic changes physiological shear. Treatments with...
Heavy menstrual bleeding is common in adolescents. The frequency and predictors of disorders adolescents, especially with anovulatory bleeding, are unknown. Adolescents referred for heavy underwent an evaluation patterns, determined a priori. primary outcome was the diagnosis disorder. Two groups were compared: ovulatory bleeding. Multivariable logistic regression analysis baseline characteristics performed. Kaplan Meier curves constructed time from first bleed to disorder diagnosis. In 200...
Abstract Cold storage of blood for 5 to 6 weeks has been shown impair endothelial function after transfusion and associated with measures end-organ dysfunction. Although the products hemolysis, such as cell-free plasma hemoglobin, arginase, heme, iron, in part mediate these effects, a complete analysis transfused metabolites that may affect organ not evaluated date. Blood stored either or 42 days was collected from 18 healthy autologous volunteers, prior into forearm circulation, followed by...
Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers risk thromboembolic complications. The role for post-transcriptional regulation the transcriptome by microRNAs (miRNAs) SCD has not been previously explored. This is first study determine whether platelets from exhibit an altered miRNA expression profile.We analyzed miRNAs isolated primary cohort (SCD = 19, controls 10) validation 7, 7) hybridizing Agilent microarrays. A...
Abstract Low von Willebrand factor (VWF) in adults is associated with significant bleeding, most notably heavy menstrual bleeding (HMB) and postpartum hemorrhage, although this has not been characterized adolescents. The objectives of analysis a multicenter single arm observational cohort study adolescents low VWF–associated HMB were to describe the phenotype, severity, related complications. Eligibility criteria included postmenarchal females <21 years age (Pictorial Blood Assessment...
Increased awareness of von Willebrand Disease (VWD) has led to more frequent diagnostic laboratory testing, which insurers often dictate be performed at a facility with off-site processing, instead coagulation onsite processing. Off-site processing is prone preanalytical variables causing falsely low levels Factor (VWF) due the additional transport required. Our aim was determine percentage discordance between and specimen for VWD in this multicenter, retrospective study. We enrolled females...
The identification of individuals at a higher risk developing caries is great interest. Isolated forms cleft lip and palate are among the most common craniofacial congenital anomalies in humans. Historically, several reports suggest that born with clefts have for caries. Caries continues to be infectious noncontagious disease worldwide burden any health system. susceptibility In this paper, we assessed experience 1,593 from three distinct populations. study included clefts, their unaffected...
To compare the rise in temperature using trephines over conventional ones during bone site preparation.An-vitro, evaluative study.Twenty implant sites were prepared pilot drill up to depth of 10 mm on bovine femoral bone. In first part, no irrigation was used. Five 2.8 mm, and other five with help trephine drills. On completion each drill, infrared thermometer used measure both tip shaft. The same procedure repeated immersed saline.Student t test evaluate significance difference.Study showed...
Adolescents with low von Willebrand factor (VWF) levels and heavy menstrual bleeding (HMB) experience significant morbidity. There is a need to better characterize these patients genetically improve our understanding of the pathophysiology bleeding. We performed whole-exome sequencing on 86 postmenarchal diagnosed VWF (30-50 IU/dL) HMB compared them 660 in-house controls. number rare stop-gain/stop-loss ClinVar "pathogenic" variants between cases controls, as well gene burden gene-set...