A5060597607- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Air Quality Monitoring and Forecasting
- Cardiovascular Health and Disease Prevention
- Energy and Environment Impacts
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Noise Effects and Management
- Renin-Angiotensin System Studies
- Genomics, phytochemicals, and oxidative stress
- Circadian rhythm and melatonin
- Tissue Engineering and Regenerative Medicine
- Knee injuries and reconstruction techniques
- Electrospun Nanofibers in Biomedical Applications
- Vehicle emissions and performance
- Redox biology and oxidative stress
- RNA regulation and disease
- Nitric Oxide and Endothelin Effects
Rutgers, The State University of New Jersey
2007-2021
Johnson University
2011-2015
Environmental and Occupational Health Sciences Institute
2012-2014
Restricting availability of essential amino acids (EAAs) limits aminoacylation tRNAs by their cognate EAAs and activates the nutrient-sensing kinase, general control nonderepressible 2 (GCN2). Activated GCN2 phosphorylates eukaryotic initiation factor (eIF2), altering gene-specific translation initiating a transcriptional program collectively described as integrated stress response (ISR). Central activation EAA deprivation is also linked to an acute aversive feeding response. Dietary...
For many individuals, daily commuting activities on roadways account for a substantial proportion of total exposure, as well peak-level exposures, to traffic-related air pollutants (TRAPS) including ultrafine particles, but the health impacts these exposures are not well-understood. We sought determine if exposure TRAPs particles during causes acute oxidative stress in respiratory tract or changes heart rate variability (HRV), measure autonomic activity.We conducted randomized, cross-over...
Context-Epidemiologic associations between acutely increased cardiorespiratory morbidity and mortality particulate air pollution are well established, but the effects of acute exposure on human gene expression changes not understood.Objective-In order to identify potential mechanisms underlying epidemiologic morbidity, we explored in humans following inhalation fresh diesel exhaust (DE), a model for pollution.Materials methods-Fourteen ethnically homogeneous (white males), young, healthy...
Dietary sulfur amino acid restriction (SAAR) improves body composition and metabolic health across several model organisms in part through induction of the integrated stress response (ISR). We investigate hypothesis that activating transcription factor 4 (ATF4) acts as a converging point ISR during SAAR. Using liver-specific or global gene ablation strategies, both female male mice, we address role ATF4 dietary show is dispensable chronic hepatokine fibroblast growth 21 while being essential...
Type II diabetes is an established cause of vascular impairment. Particulate air pollution known to exacerbate cardiovascular and respiratory conditions, particularly in susceptible populations. This study set out determine the impact exposure traffic pollution, with without particle filtration, on endothelial function diabetes. Endothelial production nitric oxide (NO) has previously been linked health. Reactive hyperemia induces a significant increase plasma nitrite, proximal metabolite NO,...
Dietary methionine restriction (MR) produces physiological responses associated with resistance to metabolic disease and increased lifespan, but the sensing mechanism remains be established. As a part of integrated stress response pathway (ISR), eukaryotic initiation factor 2 (eIF2) kinase GCN2 is sensor amino acid insufficiency by diet, drug or genetics. We hypothesized that phosphorylation eIF2 (eIF2~P) mediates phenotype dietary MR. C57Bl/6J wildtype mice (WT) deleted for Gcn2 (KO) were...
Background. Traffic-related air pollution is associated with increased cardiopulmonary morbidity and mortality. Evidence suggests that oxidative stress may mediate these adverse effects. We hypothesized passenger vehicle rides simulating a rush-hour commute would cause measurable acute changes in biomarkers of airway among healthy volunteers. Methods. Twenty nonsmoking subjects aged 18-45 were passengers Ford Taurus sedan for two 2-hr car rides. The route was primarily on major highway heavy...
Robert J Laumbach, EOHSI and UMDNJ-Robert Wood Johnson Medical School, USA David Rich, UMDNJ School of Public Health, Jicheng Gong, Lin Zhang, Junfeng (Jim) Susan Ko, Clarimel Cepeda Kathie Kelly-McNeil, wood Pamela Ohman-Strickland, Ashley Pettit Andrew Gow, Rutgers Pharmacy, Howard M Kipen,
Endothelial cell cultures were used to see how inhaled particulates might affect lung vasculature. Human umbilical vein endothelial cells plated in 6 well dishes on plastic or Matrigel. On plastic, doubled every 24 hr, forming a confluent monolayer by 48 hr. Matrigel, proliferation was limited. Capillary tubes began within 3 complete 12 and stable for minimum of 8 days. The zero time point addition particles defined as hr after plating cells. Automobile diesel particles, courtesy Dr. Sagai,...