A5101559120- Pancreatic function and diabetes
- Nerve injury and regeneration
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Selenium in Biological Systems
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Protein Kinase Regulation and GTPase Signaling
- FOXO transcription factor regulation
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Temporomandibular Joint Disorders
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Cytomegalovirus and herpesvirus research
- Cell death mechanisms and regulation
- Heavy Metal Exposure and Toxicity
- Sport and Mega-Event Impacts
- Nuclear Receptors and Signaling
- Recreation, Leisure, Wilderness Management
- Sports, Gender, and Society
- Microtubule and mitosis dynamics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Treatments and Mutations
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2023
Southwest Forestry University
2023
Liaocheng People's Hospital
2017-2022
National Clinical Research
2022
The First Affiliated Hospital, Sun Yat-sen University
2020-2021
Sun Yat-sen University
2020-2021
Air Force Medical University
2020
Liaocheng University
2019
Nanchang University
2018-2019
Taishan Medical University
2017
Mounting evidence shows that selenium possesses chemotherapeutic potential against tumor cells, including leukemia, prostate cancer and colorectal (CRC) cells. However, the detailed mechanism by which sodium selenite specifically kills cells remains unclear. Herein, we demonstrated supranutritional doses of selenite-induced apoptosis in CRC through reactive oxygen species (ROS)-dependent modulation PI3K/AKT/FoxO3a signaling pathway. First, found treatment HCT116 SW480 caused inhibition AKT...
Supranutritional selenite has anti-cancer therapeutic effects in vivo; however, the detailed mechanisms underlying these are not clearly understood. Further studies would broaden our understanding of this compound and provide a theoretical basis for its clinical application. In study, we primarily found that exposure inhibited phosphorylation cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB), leading to suppression Bcl-2 HCT116 SW480 colorectal cancer (CRC) cells....
IL‑13 is a proinflammatory cytokine associated with multiple pathological conditions and the promotion of metastasis in lung cancer. Previous studies have demonstrated that YY1 are PI3K/AKT signaling. In addition, miR‑29a has been found to play critical role cell invasion However, molecular mechanism underlying its involvement IL‑13‑induced cancer remains largely unknown. present study, we aimed investigate mediated by By using MTT wound‑scratch assays, assessed proliferation migration...
STAT3 is expressed in neural stem cells (NSCs), where a number of studies have previously shown that involved regulating NSC differentiation. However, the possible molecular mechanism and role spinal cord injury (SCI) remain unclear. In present study, potential effect NSCs was first investigated by using short hairpin RNA (shRNA)‑mediated knockdown rat <em>in vitro</em>. Immunofluorescence β3‑tubulin glial fibrillary acidic protein staining western blotting showed knocking down expression...
Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood. aim of this study was to investigate the role mitotic regulator Polo-like kinase 1 (PLK1) in development.Mouse lungs along human pulmonary arterial smooth muscle cells endothelial were used effects on PLK1. Hypoxia- or Sugen5416/hypoxia applied induce mice. Plk1 heterozygous knockout mice PLK1 inhibitors (BI 2536 BI...
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function others, and the mechanisms are unclear. In this report, we discovered that selenite, an antitumor agent, switched protective autophagy apoptosis NB4 cells. process, level survivin-2B was decreased interaction between IKK alpha nucleus attenuated, which further led decrease nuclear alpha. As result, P73, transcript factor UVRAG, downregulated....
Type 1 diabetes mellitus (T1DM) is characterized by irreversible islet β cell destruction. Accumulative evidence indicated that Cdc42 and Wnt/β-catenin signaling both play a critical role in the pathogenesis development of T1DM. Further, bio-molecular mechanisms adipose-derived mesenchymal stem cells (ADSCs)-derived insulin-producing (IPCs) remain largely unknown. Our aim was to investigate underlying mechanism Cdc42/Wnt/β-catenin pathway ADSC-derived IPCs, which may provide new insights...
Diabetes is a progressive metabolic disease characterized by hyperglycemia. Functional impairment of islet β cells can occur to varying degrees. This initially be compensated for proliferation and changes cells. Cell division control protein 42 (Cdc42) the microRNA (miRNA) miR-29 have important roles in β-cell glucose-stimulated insulin secretion (GSIS), which we further explored using mouse insulinoma cell line MIN6. Upregulation downregulation miR-29a Cdc42 were accomplished transient...
To report clinical, virological, and epidemiological features of the first death caused by a H5N6 avian influenza virus in Yunnan Province, China.The case was described clinical expression, chest radiography, blood test treatment. Real-time RT-PCR used to detect RNA environment samples. Epidemiological investigation performed including exposure history determinant, close contacts follow up, sample collection.The patient initially developed sore throat coughs on 27 January 2015. The disease...
Abstract Background Neutralizing antibodies are approved drugs to treat coronavirus disease-2019 (COVID-19) patients, yet mutations in severe acute respiratory syndrome (SARS-CoV-2) variants may reduce the antibody neutralizing activity. New monoclonal (mAbs) and remolding strategies recalled battle with COVID-19 epidemic. Results We identified multiple mAbs from phage display library made patients further characterized R3P1-E4 clone, which effectively suppressed SARS-CoV-2 infection rescued...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of global disease 2019 (COVID-19) pandemic, contains a unique, four amino acid (aa) "PRRA" insertion in spike (S) protein that creates transmembrane protease serine (TMPRSS2)/furin cleavage site and enhances viral infectivity. More research into immunogenic epitopes protective antibodies against this SARS-CoV-2 furin is needed.Combining computational experimental methods, we identified characterized an epitope...
From 1973 to 2005, the lung cancer mortality in Xuanwei had increased constantly. Effect analysis of age and non-age factors on is important for local policy-making. Demographic death data was collected used. Factors were classified into factors. The contribution two evaluated by method decomposing differences rate. For males, major contributor growth mortality, 78.46 % all attributed females, absolute 1973–1992. 1992 proportion reduced 75.39 %. Aging one risk Xuanwei, but not main factor....
Abstract Background Descending necrotizing mediastinitis (DNM) is one of the most virulent forms mediastinitis. The main causes high mortality in DNM are believed to stem from difficulty and delay diagnosis. Fast accurate identification pathogens important for treatment these patients. Metagenomics next-generation sequencing (mNGS) a powerful tool identify all kinds pathogens, especially rare complex infections. Case presentation A 64-year-old male patient was admitted intensive care unit...
Ureaplasma parvum encephalitis is a rare disease with high mortality in the neonates. While manifestations are atypical and identification of U. difficult, diagnosis would always be delayed. Metagenomic next-generation sequencing (mNGS) pre-hypothesis free technique which could theoretically detect all microbes sample. Herein we report case meningitis identified by mNGS an extremely low birth weight neonate complicated multi-system lesions. The patient was treated erythromycin ciprofloxacin,...
Abstract Background Signal transducer and activator of transcription protein 3 (STAT3) is expressed in neural stem cells (NSCs), some studies have shown that STAT3 involved regulating NSC differentiation. However, the possible molecular mechanism role spinal cord injury (SCI) are unknown. Thus, present study, we identified mechanisms by which regulates differentiation vitro investigated potential therapeutic effect transplanting STAT3-silenced NSCs rat SCI models vivo . Methods In , were...
Objective To efficiently isolate human skin fibroblast cells with rapid proliferation and to investigate the multi-lineage differentiation potential of fibroblasts into adipogenic, osteogenic, chondrogenic neurogenic directions. Methods The primary were isolated cultured from tissues. Morphological structures, flow cytometry vimentin staining used identify fibroblasts. Growth curves analysis, mitochondrial karyotype analysis cell state different generations. And finally induced...
Abstract This paper establishes a scientific training model for sports tourism based on the nonlinear differential equation. takes as research object. Then equation method is used to communication, access, risk assessment and transparency. this analyzes discusses how improve residents' participation in projects. Finally, finds that has good application prospect analysis modeling basketball projects by experimental simulation.
Objective To explore whether human umbilical cord blood mononuclear cells (HUCB-MNC) transplantation could treat Parkinson's disease (PD) . Methods 6-OHDA-lesioned PD rats were divided into two groups randomly: one group was treated with HUCB-MNCs, which isolated from and the other PBS as control. Apomorphine-induced rotation test used to evaluate motor behavior of at different times after cell transplantation. Immunochemistry conducted confirm differentiation grafted in...