A5051751803- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Legume Nitrogen Fixing Symbiosis
- Plant Virus Research Studies
- Plant Molecular Biology Research
- Plant Parasitism and Resistance
- Plant Pathogens and Resistance
- Phytoplasmas and Hemiptera pathogens
- Plant Disease Resistance and Genetics
- Plant nutrient uptake and metabolism
- Plant and Fungal Interactions Research
- Insect symbiosis and bacterial influences
- Cocoa and Sweet Potato Agronomy
- Plant Pathogens and Fungal Diseases
- Plant pathogens and resistance mechanisms
- Rice Cultivation and Yield Improvement
- Regional Economic and Spatial Analysis
- Yersinia bacterium, plague, ectoparasites research
- Signaling Pathways in Disease
- Pesticide and Herbicide Environmental Studies
- Polysaccharides and Plant Cell Walls
- Toxin Mechanisms and Immunotoxins
- Nematode management and characterization studies
- Advanced Measurement and Detection Methods
- Land Use and Ecosystem Services
Sainsbury Laboratory
2021-2025
North Sichuan Medical University
2025
University of East Anglia
2021-2025
University of California, Riverside
2015-2024
Norwich Research Park
2021-2024
China Automotive Technology and Research Center
2020-2024
Chengdu University
2023-2024
Beijing Institute of Fashion Technology
2024
Weifang University of Science and Technology
2024
Minzu University of China
2024
Gram-negative bacterial pathogens deliver a variety of virulence proteins through the type III secretion system (T3SS) directly into host cytoplasm. These secreted effectors (T3SEs) play an essential role in infection, mainly by targeting immunity. However, molecular basis their functionalities remains largely enigmatic. Here, we show that Pseudomonas syringae T3SE HopZ1a, member widely distributed YopJ effector family, interacts with jasmonate ZIM-domain (JAZ) conserved Jas domain plant...
Taking the cities along Yellow River Basin (YRB) as research objects, entropy-TOPSIS model is used to evaluate urban ecological level; and main obstacle factors that restrict improvement of level are analyzed through diagnosis model. The results show YRB has been steadily increasing, there a significant correlation with city size watershed location, gap between declined; spatial pattern characterized by "high in head tail, low center". number full-time teachers colleges, college students,...
The citrus industry is facing an unprecedented challenge from Huanglongbing (HLB). All cultivars can be affected by the HLB-associated bacterium 'Candidatus Liberibacter asiaticus' (CLas) and there no known resistance. Insight into HLB pathogenesis urgently needed in order to develop effective management strategies. Here, we use Sec-delivered effector 1 (SDE1), which conserved all CLas isolates, as a molecular probe understand virulence. We show that SDE1 directly interacts with papain-like...
Pathogen infection is a dynamic process. Here, we employ single-cell transcriptomics to investigate plant response heterogeneity. By generating an Arabidopsis thaliana leaf atlas encompassing 95,040 cells during by fungal pathogen, Colletotrichum higginsianum, unveil cell-type-specific gene expression, notably enrichment of intracellular immune receptors in vasculature cells. Trajectory inference identifies that had different interactions with the invading fungus. This analysis divulges...
ABSTRACT Ethylene inhibits nodulation in various legumes. In order to investigate strategies employed by Rhizobium regulate nodulation, the 1-aminocyclopropane-1-carboxylate (ACC) deaminase gene was isolated and characterized from one of ACC deaminase-producing rhizobia, leguminosarum bv. viciae 128C53K. degrades ACC, immediate precursor ethylene higher plants. Through action this enzyme, deaminase-containing bacteria can reduce biosynthesis Insertion mutants with mutations rhizobial ( acdS...
The concept of the coevolutionary arms race holds a central position in our understanding pathogen–host interactions. Here we identify molecular mechanisms and follow stepwise progression an natural system. We show how evolution function HopZ family type III secreted effector proteins carried by plant pathogen Pseudomonas syringae are influenced between host. surveyed 96 isolates P. identified three homologs (HopZ1, HopZ2, HopZ3) distributed among ∼45% strains. All alleles were sequenced...
1-Aminocyclopropane-1-carboxylate (ACC) deaminase has been found in various plant growth-promoting rhizobacteria, including rhizobia. This enzyme degrades ACC, the immediate precursor of ethylene, and thus decreases biosynthesis ethylene higher plants. The ACC Rhizobium leguminosarum bv. viciae 128C53K was previously reported to be able enhance nodulation peas. structural gene (acdS) its upstream regulatory gene, a leucine-responsive protein (LRP)-like (lrpL), from R. were introduced into...
Significance Phytophthora is a major threat to agriculture. However, the molecular interaction of these severe pathogens with plant hosts poorly understood. Here, we report that Suppressor RNA Silencing 1 (PSR1) effectively promotes infection in Arabidopsis thaliana by directly targeting an essential protein containing aspartate–glutamate–alanine–histidine-box helicase domain. This PSR1-Interacting Protein (PINP1) required for accumulation distinct classes endogenous small RNAs and acts as...
The genus Phytophthora consists of many notorious pathogens crops and forestry trees. At present, battling diseases is challenging due to a lack understanding their pathogenesis. We investigated the role small RNAs in regulating soybean defense response infection by sojae, second most destructive pathogen soybean. Small RNAs, including microRNAs (miRNAs) interfering (siRNAs), are universal regulators that repress target gene expression eukaryotes. identified known novel differentially...
Immune response during pathogen infection requires extensive transcription reprogramming. A fundamental mechanism of transcriptional regulation is histone acetylation. However, how pathogens interfere with this process to promote disease remains largely unknown. Here we demonstrate that the cytoplasmic effector PsAvh23 produced by soybean Phytophthora sojae acts as a modulator acetyltransferase (HAT) in plants. binds ADA2 subunit HAT complex SAGA and disrupts its assembly interfering...
Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity promote pathogen colonization. However, little is known about the targets effectors and mechanisms by which increase susceptibility. Here we report that soybean sojae uses essential PsAvh262 stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin (BiPs), act as negative regulators plant resistance Phytophthora. By stabilizing BiPs, suppresses ER stress-triggered cell death...
In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can form receptor networks to confer hypersensitive cell death innate immunity. One class of NLRs, known as NLR required for (NRCs), are central nodes in a complex network that protects against multiple pathogens comprises up half the NLRome solanaceous plants. Given prevalence this network, we hypothesised convergently evolved secrete effectors target NRC activities. To test this, screened library 165...
Abstract ‘ Candidatus Liberibacter’ species are insect‐transmitted, phloem‐limited α‐Proteobacteria in the order of Rhizobiales . The citrus industry is facing significant challenges due to huanglongbing, associated with infection from Liberibacter asiaticus’ (Las). In gain greater insight into Ca. biology and genetic diversity, we have performed genome sequencing comparative analyses diverse Ca species, including those that can infect citrus. Our phylogenetic analysis differentiates...
Citrus Huanglongbing (HLB), caused by Candidatus Liberibacter asiaticus (Las), is one of the most destructive citrus diseases worldwide, yet how Las causes HLB poorly understood. Here we show that a Las-secreted protein, SDE15 (CLIBASIA_04025), suppresses plant immunity and promotes multiplication. Transgenic expression in Duncan grapefruit (Citrus × paradisi) hypersensitive response induced Xanthomonas citri ssp. (Xcc) reduces immunity-related genes. also triggered vesicatoria effector...
Pathogens produce diverse effector proteins to manipulate host cellular processes. However, how functional diversity is generated in an repertoire poorly understood. Many effectors the devastating plant pathogen Phytophthora contain tandem repeats of "(L)WY" motif, which are structurally conserved but variable sequences. Here, we discovered a module formed by specific (L)WY-LWY combination multiple effectors, efficiently recruits serine/threonine protein phosphatase 2A (PP2A) core enzyme...
Nicotinamide adenine dinucleotide (NAD + ) has emerged as a key component in prokaryotic and eukaryotic immune systems. The recent discovery that Toll/interleukin-1 receptor (TIR) proteins function NAD hydrolases (NADase) links -derived small molecules with signaling. We investigated pathogen manipulation of host metabolism virulence strategy. Using the pangenome model bacterial Pseudomonas syringae , we conducted structure-based similarity search from 35,000 orthogroups for type III...
Many bacterial pathogens employ a type III secretion system to deliver secreted effectors (T3SEs) into host cells, where they interact directly with substrates modulate defense pathways and promote disease. This interaction creates intense selective pressures on these effectors, necessitating rapid evolution overcome surveillance systems defenses. Using computational evolutionary approaches, we have identified numerous mosaic truncated T3SEs among animal plant pathogens. We propose that...