A5042013092- Malaria Research and Control
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Complement system in diseases
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood Coagulation and Thrombosis Mechanisms
- Cytomegalovirus and herpesvirus research
- Health and Medical Studies
- COVID-19 Impact on Reproduction
- Immunodeficiency and Autoimmune Disorders
- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS drug development and treatment
- Travel-related health issues
- Sepsis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Cell death mechanisms and regulation
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- HIV-related health complications and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacillus and Francisella bacterial research
University of Rostock
2014-2024
Universitätsmedizin Rostock
2005-2024
Bernhard Nocht Institute for Tropical Medicine
1989-2019
University of Prishtina
2019
University Clinical Center of Kosovo
2019
Bundeswehrkrankenhaus
2019
Universität Ulm
1992
Roche (Switzerland)
1992
Journal Article Soluble Tumor Necrosis Factor Receptors Correlate with Parasitemia and Disease Severity in Human Malaria Get access Peter Kern, Kern Reprints or correspondence: Dr. Section of Infectious Diseases, University Ulm, Robert-Koch-Str. 8, D-7900, Germany. Search for other works by this author on: Oxford Academic PubMed Google Scholar Christoph Josef Hemmer, Hemmer Harald Gallati, Gallati Stefan Neifer, Neifer Kremsner, Kremsner Manfred Dietrich, Dietrich Franz Porzsolt The Volume...
Fever tends to start at a lower level of parasitemia in Plasmodium vivax or ovale than P. falciparum malaria, but hyperparasitemia and complications are more likely occur malaria. Therefore, we compared the relationship between host response parameters before therapy 97 patients with faciparum malaria (18 complications), 28 malaria.In both types correlated blood levels tumour necrosis factor alpha (TNF-alpha), lactate dehydrogenase (LDH), Thrombin-antithrombin III (TAT) elastase, these were...
Abstract Background. Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated (CDAD) are common complications of antibiotic use. Data on the efficacy probiotics to prevent AAD CDAD unclear. We aimed evaluate Saccharomyces boulardii in hospitalized adult patients. Methods. conducted a multicenter, phase III, double-masked, randomized, placebo-controlled trial patients who received systemic treatment 15 hospitals Germany between July 2010 October 2012. Participants Perenterol...
Crimean–Congo hemorrhagic fever (CCHF) is fatal in 10 to 40% of cases. It caused by CCHF virus (CCHFV). Symptoms include fever, headache, myalgia, and often hemorrhage other complications. This report shows that may resemble HELLP syndrome (hemolysis, elevated liver enzymes, low platelets). We a pregnant mother with suspected syndrome, who survived, her infant (week 36), died six days after C-section. The high viral load bacterial sepsis have jointly contributed the death infant. should be...
ABSTRACT To date, there have been conflicting reports concerning the clinical significance of nitric oxide (NO) in Plasmodium falciparum malaria. Some authors proposed that NO contributes to development severe and complicated malaria, while others argued has a protective role. investigate these apparently contradictory reports, reverse transcription-coupled PCR was used study inducible synthase (iNOS) whole-blood RNA samples from patients with malaria or uncomplicated healthy donors. This...
Organ failure in Plasmodium falciparum malaria is associated with neutrophil activation and endothelial damage. This study investigates whether neutrophil-induced damage involves apoptosis it can be prevented by neutralization of secretory products. Endothelial cells from human umbilical veins were coincubated neutrophils healthy donors sera eight patients P. malaria, three vivax controls. was demonstrated terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL)...
Serodiagnostic tests for antibody detection to estimate the immunoprotective status regarding SARS-CoV-2 support diagnostic management. This study aimed investigate performance of serological assays COVID-19 and elaborate on test-specific characteristics. Sequential samples (n = 636) four panels (acute COVID-19, convalescent (partly vaccinated post-infection), pre-pandemic, cross-reactive) were tested IgG by indirect immunofluorescence test (IIFT) EUROIMMUN EUROLINE Anti-SARS-CoV-2 Profile...
ABSTRACT Levels of soluble Fas ligand (sFasL) in serum were elevated patients with Plasmodium falciparum malaria and showed a significant decline during disease course. sFasL levels that before antimalarial treatment began correlated significantly depressed total lymphocyte T-cell counts. These data suggest Fas-induced apoptosis might play role malaria-associated lymphopenia.
"Neither Heparin nor Acetylsalicylic Acid Influence the Clinical Course in Human Plasmodium Falciparum Malaria: a Prospective Randomized Study" published on Nov 1991 by The American Society of Tropical Medicine and Hygiene.
"Supportive Pentoxifylline in Falciparum Malaria: No Effect on Tumor Necrosis Factor Alpha Levels or Clinical Outcome: A Prospective, Randomized, Placebo-Controlled Study" published Apr 1997 by The American Society of Tropical Medicine and Hygiene.
Summary We used thrombomodulin (TM) to assess the participation of vascular endothelium in human Plasmodium falciparum (P. F.) malaria. Before therapy TM plasma levels were elevated P. F. malaria and fell normal values during therapy. Parasitemia, TNFα, elastase TAT correlated directly with TM. Elevated can not be explained by increased synthesis, since incubating HUVEC pretherapy serum patients malaria, but reconvalescence serum, suppressed transcription. This was partially prevented adding...
A 40-year-old Asian circus elephant developed mouth and trunk ulcers. Three weeks later, her 19-year-old animal warden noticed a vesicle on his forearm, evolving into scab. Identical cowpox strains were isolated from lesions of the warden. Cowpox virus could no longer be after scab disappeared, but PCR still revealed orthopox DNA. Healing was complete seven leaving 1 cm scar.
Abstract During 2013–2016, a total of 32 patients were treated for Crimean-Congo hemorrhagic fever in Prishtina, Kosovo; 11 died. In the who died, findings included viral loads >1 × 108.5/mL, lactate dehydrogenase >2,700 U/mL, bleeding, and impaired consciousness. Ribavirin therapy had no noticeable effect this small patient sample.
Serological testing for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is used to detect ongoing or past SARS-CoV-2 infections. To study the kinetics of anti-SARS-CoV-2 and assess diagnostic performances eight serological assays, we 129 serum samples collected on known days post symptom onset (dpso) from 42 patients with polymerase chain reaction-confirmed disease 2019 (COVID-19) 54 healthy blood donors, children infected seasonal coronaviruses. The sera were...
Summary In an unmatched case–control study of 63 non‐immune European patients with uncomplicated ( n = 52) and complicated 11) falciparum malaria, serum levels N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), heart‐type fatty acid‐binding protein (H‐FABP), myoglobin, troponin T creatin kinase‐muscle brain were compared. Elevated NT‐proBNP H‐FABP indicated myocardial impairment in but not malaria. The clinical impact these findings remains to be evaluated. pathophysiology cardiac malaria...
Overhydration can contribute to fatal complications of falciparum malaria, even though renal function may be normal. In this context, the role inappropriate secretion antidiuretic hormone (ADH) has been controversial. Therefore, we have analyzed ADH serum concentrations together with osmolality and sodium levels in urine 17 consecutively studied patients severe malaria. Serum were low 13 upon admission returned normal during antiparasitic therapy. Urine seven before treatment increased high,...
Objective and Design: Apoptotic endothelial damage contributes to multiorgan failure in Plasmodium falciparum malaria sepsis. In malaria, apoptosis is amplified by neutrophils their secretory products, reduced inhibitors of neutrophil-derived substances vitro. We compared the mechanisms sepsis, using human umbilical vein cell as a model. Interventions: Endothelial cells were incubated with patient sera (P. Escherichia coli Staphylococcus aureus sepsis) or culture supernatants respective...
Zusammenfassung Hintergrund Bei Kindern verläuft die Infektion mit SARS-CoV-2, dem Erreger von COVID-19, in der Regel weniger schwer und häufiger symptomlos als bei Erwachsenen. Kinder können aber diese u. a. auf vulnerable Erwachsene übertragen. Daher sind zur Zeit Einrichtungen Kinderbetreuung Schulen teilweise geschlossen. Methoden Da sich Infektionsstatus unter 13 Jahren deren Müttern meist ähnlich darstellt, untersuchten wir 401 Rostocker zwischen 1 10 Rachenabstriche SARS-CoV-2...