A5030561197- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Trace Elements in Health
- Advanced Radiotherapy Techniques
- Musculoskeletal pain and rehabilitation
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Muscle activation and electromyography studies
- Iron Metabolism and Disorders
- Effects of Vibration on Health
- Hemoglobinopathies and Related Disorders
- Cerebrovascular and Carotid Artery Diseases
- Hedgehog Signaling Pathway Studies
- Scoliosis diagnosis and treatment
- Irish and British Studies
- Prosthetics and Rehabilitation Robotics
- Heavy Metal Exposure and Toxicity
- Functional Brain Connectivity Studies
- Connexins and lens biology
- Substance Abuse Treatment and Outcomes
- Cancer and Skin Lesions
- Prostate Cancer Treatment and Research
Imperial College Healthcare NHS Trust
2017-2024
Imperial College London
2017-2024
University of Nebraska Medical Center
2020
RMIT University
2015
Peter MacCallum Cancer Centre
2015
University of Warwick
2011-2013
There is a well-established literature indicating relationship between iron in brain tissue and Alzheimer's disease (AD). More recently, it has become clear that AD associated with neuroinflammatory oxidative changes which probably result from microglial activation. In this study, we investigated the correlative activation, stress, dysregulation mouse model of exhibits early-stage amyloid deposition. Microfocus X-ray absorption spectroscopy analysis intact sections prepared AβPP/PS1...
Purpose: Focal therapy has been proposed as an alternative method to whole‐gland treatment for prostate cancer when aiming reduce side effects. The authors recently validated a radiobiological model which takes into account tumor location and characteristics including cell density, Gleason score, hypoxia in order plan optimal dose distributions focal therapy. propose that this can be informed using multiparametric MRI (mpMRI) study present registration framework developed map mpMRI histology...
Alpha synuclein pathology is widespread and found in diverse cell types multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution unknown. Regional differences the of ir
Inductively coupled plasma mass spectrometry (ICP-MS) was used to quantify the total amount of trace elements in retina from adult male Sprague-Dawley rats (n = 6). Concentration within individual retinal areas frozen sections fellow eye established with use two methodologies: (1) particle-induced X-ray emission (PIXE) combination 3D depth profiling Rutherford backscattering (RBS) and (2) synchrotron fluorescence (SXRF) microscopy. The most abundant metal zinc, followed by iron copper....
Musculoskeletal models of the lumbar spine have been developed with varying levels detail for a wide range clinical applications. Providing consistency is ensured throughout modelling approach, these can be combined other computational and used in predictive studies to investigate bone health deterioration associated fracture risk. To provide precise physiological loading conditions such studies, new full-body musculoskeletal model including detailed consistent representation lower limbs was...
Background: There are currently no methods to estimate cell density in the prostate. This study aimed develop predictive models prostate from multiparametric magnetic resonance imaging (mpMRI) data at a voxel level using machine learning techniques.Material and methods: In vivo mpMRI were collected 30 patients before radical prostatectomy. Sequences included T2-weighted imaging, diffusion-weighted dynamic contrast-enhanced imaging. Ground truth maps computed histology co-registered with...
Linear scaling of generic shoulder models leads to substantial errors in model predictions. Customisation modelling through magnetic resonance imaging (MRI) improves outcomes, but development is time and technology intensive. This study aims validate 10 MRI-based models, identify the best combinations anthropometric parameters for scaling, quantify improvement predictions glenohumeral loading from this anatomical atlas. The anatomy was modelled using a validated musculoskeletal (UKNSM). Ten...
Amputation of a major limb, and the subsequent return to movement with prosthesis, requires development compensatory strategies account for loss. Such strategies, over time, lead regional muscle atrophy hypertrophy through chronic under or overuse muscles compared uninjured individuals. The aim this study was quantify lower limb parameters persons transtibial transfemoral amputations using high resolution MRI ascertain volume determine regression equations predicting femur- tibia-length,...
Purpose To explore the utility of diffusion and perfusion changes in primary renal cell carcinoma (RCC) after stereotactic ablative body radiotherapy (SABR) as an early biomarker treatment response, using weighted (DWI) dynamic contrast enhanced (DCE) MRI. Methods Patients enrolled a prospective pilot clinical trial received SABR for RCC, had DWI DCE MRI scheduled at baseline, 14 days 70 SABR. Tumours <5cm diameter single fraction 26 Gy larger tumours three fractions Gy. Apparent coefficient...
Background: Previous studies have identified apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can stratify prostate cancer into high- and low-grade disease (HG LG, respectively). In this study, we consider the improvement of incorporating texture features (TFs) T2-weighted (T2w) multiparametric magnetic resonance (mpMRI) relative to mpMRI alone predict HG LG disease.Material methods: vivo was acquired 30 patients prior radical prostatectomy. Sequences included T2w...
Chemical imaging of the human brain has great potential for diagnostic and monitoring purposes. The heterogeneity iron distribution, alterations to this distribution in Alzheimer's disease, indicate as a endogenous marker. influence on certain magnetic resonance (MRI) parameters increases with field, but is under-explored tissues above 7 T.
Abstract Background Biologically targeted radiation therapy treatment planning requires voxel-wise characterisation of tumours. Dynamic contrast enhanced (DCE) DCE MRI has shown promise in defining voxel-level biological characteristics. In this study we consider the relative value qualitative, semi-quantitative and quantitative assessment compared with diffusion weighted imaging (DWI) T2-weighted (T2w) to detect prostate cancer at voxel level. Methods Seventy patients had multiparametric...
Before MR fingerprinting (MRF) can be adopted clinically, the derived quantitative values must proven accurate and repeatable over a range of T1 T2 temperatures. Correct assessment accuracy precision as well comparison between measurements only performed when temperature is either controlled or corrected for. The purpose this study was to investigate dependence MRF evaluate repeatability temperature-corrected relaxation from B1 -corrected MRF-fast imaging with steady-state precession...
Motivation: T1 and T2 accuracy in the brain is difficult to assess, since there no ground truth available. Goal(s): To investigate how well relaxometry methods agree. Approach: We compare Magnetic Resonance Fingerprinting (MRF) mapping with Variable Flip Angle (VFA) Multi-Echo Spin Echo (T2) 11 anatomical regions for 10 healthy volunteers, relevant spheres of NIST phantom. Results: MRF underestimates comparison VFA MESE human brain, especially myelin-dense areas. Less bias present Impact:...
Motivation: Segmentation of quantitative maps is required to compute anatomical region mean relaxation times. FreeSurfer designed automatically segment conventional weighted images. Voxels CSF contaminate tissue segmentations in some healthy volunteers, skewing the T1 or T2. Goal(s): To remove contaminant fluid from regions interest and T2 maps. Approach: Mean ventricles used as a maximum threshold within brain tissue. Results: Thresholding prior 2D erosion masks removes prevents erroneous...
e16587 Background: Assessment of treatment response for renal cell carcinoma (RCC) is typically carried out using anatomical CT sized-based RECIST 1.1 criteria. Recently, our group completed a prospective pilot clinical trial delivering stereotactic ablative body radiotherapy (SABR) to patients with RCC (FASTRACK, number U1111-1132-5574). In this study, we assessed functional changes in tumours after SABR dynamic contrast enhanced MRI (DCE-MRI) and diffusion weighted imaging (DWI) see...
Abstract not available.