A5083439487- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Multisensory perception and integration
- Mental Health Research Topics
- Sleep and Work-Related Fatigue
- Decision-Making and Behavioral Economics
- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Musculoskeletal pain and rehabilitation
- Advanced Neuroimaging Techniques and Applications
- Pain Mechanisms and Treatments
- Tactile and Sensory Interactions
- Face Recognition and Perception
- Technology Use by Older Adults
- Psychology of Moral and Emotional Judgment
- Educational Games and Gamification
- Pain Management and Placebo Effect
- Research Data Management Practices
- Digital Mental Health Interventions
- Mind wandering and attention
Yale-NUS College
2014-2024
National University of Singapore
2012-2024
Duke-NUS Medical School
2013-2023
A*STAR-NUS Clinical Imaging Research Centre
2020
Institut des Sciences Cognitives Marc Jeannerod
2019
Vanderbilt University
2006-2013
Duke University
2013
University of Birmingham
2013
Institute of Mental Health
2013
Allen Institute for Brain Science
2010
The association cortex supports cognitive functions enabling flexible behavior. Here, we explored the organization of human by mathematically formalizing notion that a behavioral task engages multiple components, which are in turn supported overlapping brain regions. Application model to large data set neuroimaging experiments (N = 10 449) identified complex zones frontal and parietal regions ranged from being highly specialized flexible. network was with an independent resting-state fMRI...
Abstract How individual differences in brain network organization track behavioral variability is a fundamental question systems neuroscience. Recent work suggests that resting-state and task-state functional connectivity can predict specific traits at the level. However, most studies focus on single traits, thus not capturing broader relationships across behaviors. In large sample of 1858 typically developing children from Adolescent Brain Cognitive Development (ABCD) study, we show...
Human information processing is characterized by bottlenecks that constrain throughput. These limit both what we can perceive and act on in multitask settings. Although perceptual response limitations are often attributed to independent bottlenecks, it has recently been suggested a common attentional limitation may be responsible for both. To date, however, evidence supporting the existence of such “unified” bottleneck mixed. Here, tested unified hypothesis using time-resolved fMRI....
An influential theory suggests that integrated objects, rather than individual features, are the fundamental units limit our capacity to temporarily store visual information (S. J. Luck & E. K. Vogel, 1997). Using a paradigm independently estimates number and precision of items stored in working memory (W. Zhang S. Luck, 2008), here we show storage features is not cost-free. The objects held was estimated when observers had remember either color, orientation, or both color orientation simple...
There is significant interest in using neuroimaging data to predict behavior. The predictive models are often interpreted by the computation of feature importance, which quantifies relevance an imaging feature. Tian and Zalesky (2021) suggest that importance estimates exhibit low split-half reliability, as well a trade-off between prediction accuracy reliability across parcellation resolutions. However, it unclear whether universal. Here, we demonstrate that, with sufficient sample size,...
Attention and awareness are two tightly coupled processes that have been the subject of same enduring debate: Are they allocated in a discrete or graded fashion? Using attentional blink paradigm mixture-modeling analysis, we show arises at central stages information processing an all-or-none manner. Manipulating temporal delay between targets affected subjects’ likelihood consciously perceiving second target, but did not affect precision its representation. Furthermore, these results held...
The posterior lateral prefrontal cortex—specifically, the inferior frontal junction (IFJ)—is thought to exert a key role in control of attention. However, precise nature that remains elusive. During voluntary deployment and maintenance visuospatial attention, IFJ is typically coactivated with core dorsal network consisting eye field superior parietal cortex. stimulus-driven instead couples ventrolateral network, suggesting plays attention distinct from network. Because rapidly switches...
Information enters the cortex via modality-specific sensory regions, whereas actions are produced by motor regions. Intervening central stages of information processing map sensation to behavior. Humans perform this in a flexible, abstract manner such that any modality can lead response system. Cognitive theories account for flexible behavior positing amodal (e.g., "central executive," Baddeley and Hitch, 1974; "supervisory attentional system," Norman Shallice, 1986; "response selection...
Abstract Conventional therapeutic interventions, which range from drug treatment to learning and training regimens, are often given at a fixed dose/intensity. This leads sub‐optimal responses, or even none all. Similarly, intensity can lead plateaus in trajectories outcomes. barrier will impact the field of digital therapeutics, where drug‐based therapies may be complemented replaced by platforms. A potential solution is optimize identifying N‐of‐1 (single subject) profiles that then enhance...
The cost of attending to a visual event can be the failure consciously detect other events. This processing limitation is well illustrated by attentional blink paradigm, in which searching for and target presented rapid serial presentation stream distractors impair one's ability second soon thereafter. critically depends on 'top-down' settings, it does not occur if participants are asked ignore first target. Here we show that 'bottom-up' attention also lead profound but ephemeral deficit...
Attention is a critical cognitive function, allowing humans to select, enhance, and sustain focus on information of behavioral relevance. contains dissociable neural psychological components. Nevertheless, some brain networks support multiple attentional functions. In this study, we used the visual blink (VAB) as test functional generalizability brain's networks. VAB task, attention devoted target often causes subsequent item be missed. Although frequently attributed limitations in capacity...
Patients with schizophrenia exhibit impairments in working memory that often appear attenuated form persons at high risk for the illness. The authors hypothesized deviations task-related brain activation and deactivation would occur an at-risk mental state performing a task entailed maintenance manipulation of letters.Participants ultra developing psychosis (N=60), identified using Comprehensive Assessment At-Risk Mental States, healthy comparison subjects (N=38) 14 to 29 years age underwent...
Conventional interventional modalities for preserving or improving cognitive function in patients with brain tumour undergoing radiotherapy usually involve pharmacological and/or rehabilitation therapy administered at fixed doses intensities, often resulting suboptimal no response, due to the dynamically evolving patient state over course of disease. The personalisation interventions may result more effective results this population. We have developed CURATE.AI COR-Tx platform, which...
Eyelid closures in fatigued individuals signify task disengagement attention-demanding visual tasks. Here, we studied how varying degrees of eyelid closure predict responses to auditory stimuli depending on whether a participant is well rested or sleep deprived. We also examined time-on-task effects and more less vulnerable differed frequency eye lapses.Six repetitions an vigilance were performed each two sessions: wakefulness (RW) total deprivation (TSD) (order counterbalanced).Sleep...
Object recognition becomes impaired at faster presentation rates and here we show the neuroanatomical foci of where this might be exacerbated by sleep deprivation (SD). Twenty healthy human participants were asked to detect a target house in serially presented pictures that appeared 1-15images/s. Temporal response profiles relating fMRI signal magnitude frequency derived from task-responsive regions. Following SD, inverted U-shaped profile within parahippocampal place area was lower peaked...