A5100726288- Metabolomics and Mass Spectrometry Studies
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Pharmacogenetics and Drug Metabolism
- Chromatography in Natural Products
- Endometrial and Cervical Cancer Treatments
- Ginseng Biological Effects and Applications
- Cholesterol and Lipid Metabolism
- Plasma Applications and Diagnostics
- Alkaloids: synthesis and pharmacology
- Lipid metabolism and disorders
- Genetics, Bioinformatics, and Biomedical Research
- Axial and Atropisomeric Chirality Synthesis
- Reproductive System and Pregnancy
- Phytochemistry and Biological Activities
- Ovarian cancer diagnosis and treatment
- Cardiac Ischemia and Reperfusion
- Drug Transport and Resistance Mechanisms
- Mercury impact and mitigation studies
- Advanced Proteomics Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Sphingolipid Metabolism and Signaling
- Hormonal Regulation and Hypertension
Hangzhou First People's Hospital
2024
Westlake University
2024
Sun Yat-sen University
2018-2020
Guangzhou University
2018-2019
Nanjing Agricultural University
2019
Suzhou Polytechnic Institute of Agriculture
2019
Shuguang Hospital
2018
Shanghai University of Traditional Chinese Medicine
2018
Second Military Medical University
2010-2017
The Ohio State University
2014
Activation of pregnane X receptor (PXR), a nuclear that controls xenobiotic and endobiotic metabolism, is known to induce liver enlargement, but the molecular signals cell types responding PXR-induced hepatomegaly remain unknown. In this study, effect PXR activation on enlargement change was evaluated in several strains genetically modified mice animal models. Lineage labeling using AAV-Tbg-Cre-treated Rosa26EYFP or Sox9-CreERT, performed Pxr-null AAV Yap short hairpin RNA (shRNA)-treated...
The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. clinical indicator cancer antigen 125 (CA125) performs poorly in the diagnosis minimal with a 24%. Therefore, it is urgent to explore novel biomarkers. We evaluated metabolomic profile variation eutopic endometrium between minimal-mild endometriosis patients healthy women by ultra-high-performance liquid chromatography coupled electrospray ionization...
The sensitivity and specificity of clinical diagnostic indicators noninvasive methods for endometriosis at early stage is not optimal. Previous studies demonstrated that abnormal lipid metabolism was involved in the pathological development endometriosis. Our cross-sectional study included 21 patients with laparoscopically confirmed I-II 20 infertile women who underwent laparoscopy combined hysteroscopy from January 2014 to 2015. Eutopic endometrium collected by pipelle endometrial biopsy....
Abstract This work describes a novel methodology for unequivocal identification of chemical constituents in Zhimu‐Baihe herb‐pair (ZMBHHP). Compounds were removed from ZMBHHP by ultrasonic extraction with 70% ethanol, and then analyzed fast high‐performance liquid chromatography (HPLC) coupled time‐of‐flight mass spectrometry (TOFMS). The accurate‐mass capability the TOF analyzer allowed reliable confirmation identity detected compounds, normally errors below 3 ppm routine analysis. accuracy...
Objective . This study aimed to analyze the differential metabolites and their metabolic pathways from serum of patients with hepatitis B cirrhosis, two typical patterns Gan Dan Shi Re (GDSR) Shen Yin Xu (GSYX) based on theory traditional Chinese medicine (TCM). It also investigated variation in internal material basis for types provided an objective classifying TCM using metabolomic techniques. Methods The samples taken 111 qualified (40 GDSR cases, 41 GSYX 30 Latent Pattern (LP) cases no...
To study the radiation-induced blood deficiency and combination of prescription syndrome Siwu Tang using ultra performance liquid chromatography-quadrupoles-time flight mass spectrometer (UPLC-ESI-Q-TOF-MS), in order to discover changes metabolic profiles deficient mice induced by radiation, clarify relationship between mechanism Tang.Thirty six C57 were randomly divided into three groups: control group model groups group. The was established general irradiation with 3.5 Gy60 Coy ray....
Ultrahigh-performance liquid chromatography–quadrupole-time of-flight mass spectrometry (UHPLC–Q-TOF-MS) was widely used in identification of complex ingredients traditional Chinese herbs and herbal medicinal preparations for its excellent performance. Yangxinshi tablet, a compound formula, has efficacy the clinical treatment cardiovascular diseases, but active are unclear. In this study, rapid sensitive UHPLC–Q-TOF/MS secondary (MS2) method were developed to characterize comprehensive...