A5052713266- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Physiological and biochemical adaptations
- Receptor Mechanisms and Signaling
- Electrochemical Analysis and Applications
- Adenosine and Purinergic Signaling
- Environmental Toxicology and Ecotoxicology
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Bat Biology and Ecology Studies
- Electrochemical sensors and biosensors
- Aquaculture Nutrition and Growth
- Photoreceptor and optogenetics research
- Ocean Acidification Effects and Responses
- Biochemical effects in animals
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
Pirogov Russian National Research Medical University
2014-2024
Lomonosov Moscow State University
2015-2024
National Medical Research Center of Cardiology
2020-2024
Shenzhen MSU-BIT University
2023-2024
Moscow State University
2009-2024
Shenzhen Technology University
2023-2024
Institute of Experimental Cardiology
2008-2021
Ural Federal University
2019-2021
Institute of Chemistry, Komi Science Center
2020
Ural Branch of the Russian Academy of Sciences
2020
Acidosis often occurs during clinical complications in newborns and can lead to changes the mechanisms of arterial tone regulation. However, it is unknown how acidosis affects activity Ca2+-activated chloride channels (CaCC) arteries early ontogenesis. We hypothesized that their may increase acidosis. studied isometric contractions saphenous isolated from adult 10-13-day-old rats. Intracellular pH was measured using a fluorescent indicator BCECF-AM simultaneously with recording contractile...
Favorable versus detrimental cardiovascular responses to intermittent hypoxia conditioning (IHC) are heavily dependent on experimental or pathological conditions, including the duration, frequency and intensity of exposures. Recently, we demonstrated that a program moderate, normobaric IHC (FIO 2 9.5–10% for 5–10 min/cycle, with intervening 4 min normoxia, 5–8 cycles/day 20 days) in dogs afforded robust cardioprotection against infarction arrhythmias induced by coronary artery...
Ion homeostasis plays a central role in polarisation and polar growth. In several cell types ion channels are controlled by reactive oxygen species (ROS). One of the most important cells plant life cycle is male gametophyte, which grows under tight control both fluxes ROS balance. The precise relationship between these two factors pollen tubes has not been completely elucidated, grains it never studied to date. present study we used simple model - protoplasts obtained from lily at early...
Oil and gas exploration in the Arctic can result release of polycyclic aromatic hydrocarbons (PAHs) into relatively pristine environments. Following recent spill approximately 17 500 tonnes diesel fuel Norilsk, Russia, May 2020, our study focussed on effects phenanthrene, a low molecular weight PAH found crude oil, isolated atrial ventricular myocytes from heart polar teleost, Navaga cod (Eleginus nawaga). Acute exposure to phenanthrene navaga cardiomyocytes caused significant action...
Background Mutations in ATP1A2 gene encoding the Na,K‐ATPase α 2 isoform are associated with familial hemiplegic migraine type 2. Migraine aura is a known risk factor for heart disease. The important cardiac function, but its role disease remains unknown. We hypothesized that susceptibility and aimed to assess underlying mechanism. Methods Results Mice heterozygous 2–associated G301R mutation Atp1a2 (α +/G301R mice) matching wild‐type controls were compared. Reduced expression of increased 1...
Seasonal thermal remodelling (acclimatization) and laboratory (acclimation) can induce different physiological changes in ectothermic animals. As global temperatures are changing at an increasing rate, there is urgency to understand the compensatory abilities of key organs like heart adjust under natural conditions. Thus, aim present study was directly compare acclimatization acclimatory response within a single eurythermal fish species, European shorthorn sculpin (Myoxocephalus scorpio L.)....
Background: The three-ringed polycyclic aromatic hydrocarbon (PAH) phenanthrene (Phe) has been implicated in the cardiotoxicity of petroleum-based pollution aquatic systems, where it disrupts contractile and electrical function fish heart. Phe is also found adsorbed to particulate matter gas phase air pollution, but date, no studies have investigated impact on mammalian cardiac function. Objectives: Our objectives were determine arrhythmogenic potential acute exposure define underlying...
Temperature-induced changes in cardiac output (Q̇) fish are largely dependent on thermal modulation of heart rate (fH), and at high temperatures Q̇ collapses due to heat-dependent depression fH This study tests the hypothesis that firing sinoatrial pacemaker cells sets upper limit vivo. To this end, temperature dependence action potential (AP) frequency enzymatically isolated (pacemaker rate, fPM), spontaneous beating preparations (fSA), vivo cold-acclimated (4°C) brown trout (Salmo trutta...
Abstract Aims: Changes in the rabbit sinoatrial node (SAN) activation sequence with cholinergic and adrenergic factors were studied. The correlation between sinus rhythm rate leading pacemaker site shift was determined. hypothesis concerning suppression of nodal cell excitability as one mechanisms associated tested. Methods: A high‐resolution optical mapping technique used to register beat‐to‐beat changes SAN pattern under influence factors. Results: Acetylcholine (10 μ m ) strong intramural...
Acetylcholinesterase (AChE) inhibitors provoke typical cholinergic effects in the isolated right atrium of rat due to accumulation acetylcholine (ACh). Our study was designed show that absence vagal impulse activity, ACh is released from parasympathetic nerve fibres by means non-quantal secretion. The conventional microelectrode technique used changes action potential (AP) configuration preparation rats during application AChE inhibitors. Staining with lipophilic fluorescent dye FM1-43...
The mechanoelectrical feedback (MEF) mechanism in the heart that plays a significant role occurrence of arrhythmias, involves cation flux through nonselective stretch-activated channels (SACs). It is well known nitric oxide (NO) can act as regulator MEF. Here we addressed possibility SAC's regulation along NO-dependent and NO-independent pathways, S-nitrosylation SACs. In freshly isolated rat ventricular cardiomyocytes, using patch-clamp method whole-cell configuration, inward current I
Carbon monoxide (CO) is a toxic gas, which also acts in the organism as neurotransmitter. It generated by-product of heme breakdown catalyzed by oxygenase. We have investigated changes electrical and contractile activity isolated rat atrial ventricular myocardium preparations under influence CO. Standard microelectrode technique was used for intracellular registration myocardium. Contractions myocardial stripes were registered via force transducer. CO (10-4 - 10-3 M) caused prominent...