A5101621355- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Eicosanoids and Hypertension Pharmacology
- Ferroptosis and cancer prognosis
- Orthopaedic implants and arthroplasty
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Advanced Nanomaterials in Catalysis
- Inflammatory mediators and NSAID effects
- Spinal Cord Injury Research
- Lattice Boltzmann Simulation Studies
Sichuan University
2024-2025
Air Force Medical University
2025
Soochow University
2007-2024
First Affiliated Hospital of Soochow University
2007-2024
State Key Laboratory of Oral Diseases
2024
Affiliated Hospital of Hebei University
2024
Qilu Hospital of Shandong University
2022-2023
Southwest Medical University
2022-2023
Zhejiang Wanli University
2022
Stomatology Hospital
2022
Epithelial-mesenchymal transition (EMT) is a dedifferentiation process that mainly involves in mesenchymal marker upregulation, epithelial maker downregulation and cell polarity loss. Related hypoxia factors play crucial role EMT, however, it remains few evidence to clarify the of HIF-2α EMT pancreatic cancer. In this study, we investigated expression E-cadherin by immunohistochemistry 70 cancer patients, as well correlation clinicopathologic characteristics. Then regulated cells examine on...
The newly proposed Global Leadership Initiative on Malnutrition (GLIM) framework is promising to gain global acceptance for diagnosing malnutrition. However, the role of machine learning in facilitating its application clinical practice remains largely unknown.We performed a multicenter, observational cohort study including 3998 patients with cancer. Baseline malnutrition was defined using GLIM criteria, and population randomly divided into derivation group (n = 2998) validation 1000). A...
Intermuscular bones (IBs) are small, hard-boned spicules located in the muscle tissue that mainly exist myosepta of lower teleosts, which hurt edibleness and economic value fish. The study development IBs is very important for freshwater aquaculture fish, but molecular mechanism its formation key regulatory genes remain unclear. In this study, we first constructed two types zebrafish mutants (the losing with partial deletion IBs) by knocking out bmp6. We then carried a transcriptomic...
Rationale: Sepsis-induced cardiomyopathy (SIC) is a rapidly progressing condition with poor prognosis in the absence of effective therapeutic interventions. Cardiomyocyte pyroptosis critical factor contributing to cardiac dysfunction SIC. Currently, research on this mechanism remains unclear. Methods: We performed LPS-induced primary mouse cardiomyocyte modeling and SIC modeling. Through mRNA-Seq, we found significant tissue mice. Further confocal microscopy immunoprecipitation results...
Vasculogenic mimicry (VM) is a blood supply modality that occurs independently of endothelial cell angiogenesis. Hypoxia and the epithelial-mesenchymal transition (EMT) induce VM formation by remodeling extracellular matrix. Our previous study demonstrated hypoxia-inducible factor-2 alpha (HIF-2α) promotes progress EMT in pancreatic cancer; however, whether HIF-2α cancer remains unknown. In this study, we investigated expression immunohistochemistry 70 patients as well role Twist1and Twist2...
Increasing evidence has demonstrated that malignant cells exhibit increased glucose uptake, which facilitates survival and growth in a hypoxic environment. The transporter-1 (GLUT-1) is overexpressed variety of tumors. However, the association between GLUT-1 expression clinicopathological factors, 18F-fluorodeoxyglucose uptake tumor proliferation pancreatic cancer not been investigated to date. In present study, 53 tissues was analyzed, revealed tissue correlated with poor prognosis...
In this study, we examined the effect of GP130-targeting molecule, LMT-28, on lipopolysaccharide- (LPS-) induced bone resorption around implants in diabetic models using vitro and rat animal experiments. First, LMT-28 was added to osteoblasts stimulated by LPS advanced glycation end products (AGEs), nuclear factor-κB receptor-activating factor ligand (RANKL) associated pathways were evaluated. Then, administered gavage at 0.23 mg/kg once every 5 days for 2 weeks type rats with...
// Ye Li 1, 2, * , Xu Zhang 3, 4, Jian Yang Yi 1 Dongming Zhu 2 Lifeng Yanbo 5 Dechun and Zhou Department of General Surgery, The First Affiliated Hospital Soochow University, Suzhou 215006, China Pancreatic Disease Research Centre, 3 Science & Technology Town Hospital, 4 to Nanjing Medical Oncology, These authors have contributed equally this work Correspondence to: Zhou, email: zhoujian20150602@126.com Keywords: BNIP3, HIF-1α, apoptosis, methylation, pancreatic cancer Received:...
The prognostic value of postoperative 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to patients with gastric cancer remains unclear. This study aims investigate the whole body (WB) metabolic tumor burden (MTBWB) on postsurgical 18F-FDG PET/CT cancer. A total 376 surgeries-confirmed were enrolled. Clinicopathologic information, overall survival (OS) and MTBWB parameters PET/CT, in terms WB maximum standardized uptake (SUVWBmax), volume (MTVWB),...
Molecular residual disease (MRD) is a promising biomarker in colorectal cancer (CRC) for prognosis and guiding treatment, while the whole-exome sequencing (WES) based tumor-informed assay standard evaluating MRD on circulating tumor DNA (ctDNA). In this study, we assessed feasibility of fixed-panel CRC.
Traumatic spinal cord injury (SCI) represents a complex neuropathological challenge that significantly impacts the well-being of affected individuals. The quest for efficacious antioxidant and anti-inflammatory therapies is both compelling necessity formidable challenge. Here, in this work, innovative synthesis electron-rich Ru clusters on non-stoichiometric copper hydroxide contain oxygen vacancy defects (Ru/def-Cu(OH)
Although colorectal cancer (CRC) is common, there a paucity of information regarding its molecular pathogenesis. Studies have shown that miRNAs play pivotal roles in the development and progression CRC. There need to further investigate biological functions In particular, it has been reported miR-942-5p exhibits tumor-suppressive properties. Thus, we analyzed functional significance CRC underlying mechanisms. We found was downregulated tissues cells. Cell Counting Kit-8, EdU, colony...
It is currently unclear if a low insertion torque (IT) should prompt clinician to submerge the dental implant at time of placement.This study aimed analyze failure rates and marginal bone loss (MBL) as function IT surgical approach.A total 197 patients who had received 295 Mozo Grau (MG) implants were included in this study. The healing submerged or nonsubmerged was evaluated regular (≥20-25 Ncm) (<20-25 cases. Implant MBL before prosthesis placement 6 12 months after functional loading with...
Purpose: Colorectal cancer (CRC) is the third most common in China and poses high morbidity mortality.In recent years, increasing evidence has indicated that microRNAs played important functions occurrence development of tumors.The purpose this study was to identify biological mechanisms miR-362 CRC.Materials Methods: Quantitative real-time PCR carried out assess expression SIX1.The Kaplan-Meier method employed evaluate 5-year overall survival CRC patients.The proliferative invasive...
Why MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort
This study aimed to develop and validate a nomogram with preoperative nutritional indicators tumor markers for predicting prognosis of patients pancreatic ductal adenocarcinoma (PDAC). We performed bicentric, retrospective including 155 eligible PDAC. Patients were divided into training group (n = 95), an internal validation 34), external 26), entire 60). Cox regression analysis was conducted in the identify independent prognostic factors construct overall survival (OS) prediction. The...
To investigate the differential expression of RBPs in cervical squamous cell carcinoma (CESC), analyze regulatory effect narcotic drugs on RBPs, and establish prognostic risk model CESC patients.RNA-SEQ data clinical case cancer normal samples from patients were obtained Cancer Genome Atlas (TCGA) database Genotype-Tissue Expression (GTEx) database. Differentially expressed screened by R language enriched. The CMAP is used to predict anesthetic that regulate RBPs. score was constructed COX...