A5062896969- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects and Toxicity Studies
- Blood groups and transfusion
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Pleural and Pulmonary Diseases
- Platelet Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Lymphoblastic Leukemia research
- DNA Repair Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Sarcoma Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Heavy Metal Exposure and Toxicity
- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Neurological Complications and Syndromes
Ankara Yıldırım Beyazıt University
2022-2025
Pediatrics and Genetics
2024
Ankara Bilkent City Hospital
2024
Memorial Ankara Hospital
2015-2023
City Hospital
2021-2023
Sağlık Bilimleri Üniversitesi
2018-2023
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2018-2022
University of Health Science
2021-2022
Universidad CES
2022
University of Health Sciences Antigua
2022
Background: The lung is one of the organs that can be damaged in patients with thalassemia major (TM). In this study, we aimed to evaluate pattern impairment using various pulmonary tests and effects transfusion on functions TM. Materials Methods: study was performed 9-21 years age prospectively. Spirometric tests, plethysmography, CO diffusion were before 2 h after erythrocyte transfusion. Patients also underwent a methacholine stimulation test Results: A total 37 TM included study. There...
Malnutrition is a common consequence of cancer in children, but the most effective methods nutrition intervention are under debate. We aimed to evaluate nutritional status children diagnosed with cancer, and investigate effect oral supplements on anthropometric measurements, biochemical parameters, outcome. A randomized clinical study 45 newly patients was performed. Anthropometric data related factors were assessed at 0, 3, 6 months after diagnosis. On initial assessment, prevalence...
Since the beginning of Syrian civil war, more than 3.5 million Syrians have been under temporary protection status in Turkey. Because beta-thalassemia (BT) is a prevalent disorder Mediterranean countries, we decided to estimate prevalence and make an overview demographic, socioeconomic, medical characteristics, healthcare problems refugee children with BT.Eighteen Turkish Pediatric Hematology Oncology Centers (PHOC) 318 from 235 families participated study. The mean age patients was 8.1 ±...
In this study, we aimed to evaluate the incidence, risk factors, causes and clinical management of intracranial haemorrhage (ICH) diagnosed during foetal life or in first month term neonates with a discussion role haematological factors. This study included (gestational age 37-42 weeks) ICH diagnosed, treated followed up Neonatal Intensive Care Unit Hacettepe University, Ankara, Turkey, between January 1994 2014. Medical follow-up was obtained retrospectively from hospital files...
Chronic lymphocytic leukemia/lymphoma (CLL) is an extremely rare disease during childhood. We report a 16‐year‐old female who presented with lymphadenopathies and she was diagnosed as T cell lymphoblastic lymphoma. Her chemotherapy response minimal clinical findings were unusual. Therefore, her biopsy specimen re‐examined diagnosis changed to CLL. Chemotherapy protocol including fludarabine, cyclophosphamide, rituximab administrated good observed. In our patient deletion at 1q21.2 region...
Neonates born to mothers with immune thrombocytopenic purpura (ITP) have an increased risk of having thrombocytopenia and bleeding. The aim our study was determine maternal fetal factors that can predict bleeding in neonates ITP, effective treatment strategies by retrospective analysis single-center data. We performed a data review were recorded as 'neonates ITP' the Neonatal ICU Hacettepe University, Ihsan Dogramacı Children's Hospital, Ankara, Turkey. Medical records 36 from 35 analyzed....
Abstract Background Brain atrophy, abnormal pituitary morphology, corpus callosum, and posterior fossa abnormalities have been described in patients with Fanconi anemia (FA). We aimed to provide an overview of cranial neuroimaging findings evaluate the clinical implications FA patients. Procedure Cranial magnetic resonance imaging (MRI) studies 34 were retrospectively evaluated, patients’ data correlated findings. Results The median age was 17.6 (range, 3.9‐28) years. At least one...
Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiologic condition characterized by headache, seizures, impaired vision, acute hypertension, typical cranial MRI findings. Observation: A 10-year-old boy with FLT3-ITD-positive myelogenous leukemia who developed PRES during sorafenib treatment has been presented here. In English literature, there are 2 adult patients metastatic cholangiocarcinoma or hepatocellular carcinoma under treatment. Our patient the...
Adequate nutrient intake should be provided for the cure of children diagnosed with cancer. The aim this study was to evaluate serum trace elements and vitamins cancer at diagnosis during treatment. Children newly who were admitted our center evaluated selenium, iron, ferritin, C-reactive protein, vitamin B12, folate, 25-OH D levels presentation, third sixth months Forty-two (male/female: 15/27) a median age 8 years (range, 2 17) included in study. Mean iron within normal ranges, but...
Peripheral neuropathy is one of the complications β-thalassemia (β-thal) that has been investigated in limited reports. We aimed to detect rate peripheral and risk factors for development patients with β-thal. The study was performed β-thal intermedia (β-TI) or major (β-TM). Prospective electrophysiological studies were achieved via standard procedures. A total 27 enrolled study. Electrophysiological both motor sensory nerves within normal range. In nerve studies, delayed peroneal latency...
Anaphylaxis with midazolam in pediatric hematologyoncology unit: a case report Dear Editor, Four courses of chemotherapy were given to 17-yearold male patient (body weight 73 kg) who was being followed up diagnosis acute myeloid leukemia our Pediatric Hematology-Oncology Clinic and bone marrow aspiration lumbar puncture performed before each course.Throughout these treatments, sedation provided seven times performed.The had no known history drug allergy or food allergy.The taken into the...
The aim of the study was to analyze characteristics posterior reversible encephalopathy syndrome (PRES) cases treated at 10 different institutions in our country. Fifty-eight patients diagnosed with PRES were included this study. data from departments pediatric hematology/oncology analyzed. mean age time diagnosis 8.95±3.66 years. Most (80.4%) had a primary acute leukemia. Patients received chemotherapy (71.4%) and/or used steroids within 14 days before (85.7%). Hypertension found 83.9%...
Background Fanconi anemia (FA) is a heterogeneous autosomal recessive (and rarely X linked) disorder, which characterized by congenital malformations, progressive bone marrow failure, and predisposition to malignancies. Hematopoietic stem cell transplantation (HSCT) the only definitive treatment for hematological manifestations in FA. Procedure Twenty‐seven patients with FA underwent HSCT using fludarabine (Flu) based regimen at our center between April 2004 May 2014. One patient who...
Figure 1.The peripheral blood smear of the patient: prominent elliptocytic erythrocytes, in addition to microcytic erythrocytes (arrows) and fragmented (circles).
Iron chelation therapy is one of the mainstays management patients with β-thalassemia (BT) major. Deferasirox an oral active iron chelating agent. Proteinuria potential renal adverse effects deferasirox, and monthly follow-up for proteinuria suggested by Food Drug Administration European Medicine Agency.We aimed to investigate necessity monitoring among BT on deferasirox. A retrospective laboratory clinic data review was performed major or intermedia who were treated deferasirox therapy. All...
Myocarditis can develop secondary to several medications. Here, we report a case of myocarditis related the use lamotrigine. A 15-year-old boy was admitted another hospital because chest pain that sustained for 30 minutes. He transferred our after detection cardiac enzyme elevation. evaluated in center, where electrocardiography revealed non-specific ST elevation at inferior derivations, and level troponin T found be 0.47 ng/ml (0-0.1), while creatinin kinase MB 38 (0-4.97). Systolic...
Hypereosinophilic syndrome (HES) is a very rare disease during childhood. It involves the different organs like skin, gastrointestinal system, heart and lungs, besides pulmonary hypertension (PHT) morbidity of HES that may cause life-threatening complications. PHT improves with treatment hypereosinophilia, without need for vasodilator therapy. Here, we present case developed after recovery infiltration in an infant idiopathic HES. We revealed pressure returned to normal range parallel...
Background: Port catheters facilitate the administration of chemotherapy, antibiotics, blood products, fluid and parenteral nutritional support to pediatric patients with hematological malignancies. However, as its use has become widespread, local, systemic catheter-related infections have emerged important causes morbidity mortality. In our study, we aimed evaluate success antibiotic lock therapy in port catheter- related followed up acute leukemia. Methods: catheter cultures taken from a...
Background/aimTransfusion of blood products is a life-saving clinical practice in patients with bleeding, hemoglobinopathy and cancer. In this study, we aimed to analyze the frequency types component-related acute transfusion reactions (ATR) pediatric patients.Materials methodsThis retrospective study was conducted at tertiary care academic hospital.ResultsDuring period, 30,811 transfusions were administered 25,448 patients. 103 ATRs detected 81 (0.33%; 3.34 per 1000 transfusions, mean age...