A5014590544- Cancer-related gene regulation
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Astrophysics and Cosmic Phenomena
- Neutrino Physics Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Proteoglycans and glycosaminoglycans research
- Hematopoietic Stem Cell Transplantation
- Chromatin Remodeling and Cancer
- Oral and Maxillofacial Pathology
- dental development and anomalies
- Bone and Dental Protein Studies
- Genomics and Chromatin Dynamics
- Radio Astronomy Observations and Technology
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Lysosomal Storage Disorders Research
- Cell death mechanisms and regulation
- Periodontal Regeneration and Treatments
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- Lung Cancer Treatments and Mutations
Ankara University
2014-2024
Memorial Ankara Hospital
2014-2024
Ankara Bilkent City Hospital
2024
Bilkent University
2018-2024
Istanbul Medipol University
2019-2023
Bayındır Hastanesi
2023
Istanbul University
2022
Biruni University
2021-2022
Ruhr University Bochum
2020-2022
Ministry of Health
2014-2021
Amino acids, especially branched-chain amino acids such as l-Leucine, have been revealed to regulate activation of p70 S6 kinase and phosphorylation 4E-BP1 through mTOR signaling pathway. In this study, we showed that a cationic acid, l-Arginine, also activated pathway in rapamycin-sensitive manner rat intestinal epithelial cells, l-Arginine-induced acid signal transduction involved the transport system. The l-Arginine- l-Leucine-induced depended on stimulation time concentration each which...
Loss of heterozygosity (LOH) has been frequently detected at chromosome 7q31 region in human head and neck squamous cell carcinomas (HNSCC) many other cancers, suggesting the existence tumor suppressor genes (TSG). We analysed LOH 49 HNSCC by using six polymorphic microsatellite markers found allelic deletion 48% (22/46) informative cases. two preferentially deleted regions, one is around D7S643 D7S486. When we redefined map according to contiguous sequences, a recently identified gene,...
Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a systemic inflammatory marker, and recently, it has been used quite commonly for the assessment of inflammation in cardiovascular disorders. The aim present study investigate relevance MHR as marker assess metabolic syndrome (MetS) MetS severity clinical practice. A total 147 patients with who were diagnosed according National Cholesterol Education Program Adult Treatment Panel III criteria 134 healthy controls, matched age...
BACKGROUND:This study aimed to investigate the prevalence of malnutrition and explore somatic, psychological, functional, social or lifestyle characteristics linked in elderly people at a hospital Turkey. MATERIAL AND METHODS:This included 1030 patients older than 65 years age who were seen internal medicine geriatrics outpatient clinics centers Istanbul, Ankara, Duzce, Corum, Mardin, Malatya, Diyarbakir provinces between January December 2014. All underwent Mini Nutritional Assessment (MNA)...
In this study, we examined the distribution of heparanase protein in 75 esophageal squamous cell carcinomas by immunohistochemistry and analyzed relationship between expression clinicopathological characteristics. situ hybridization showed that mRNA pattern was similar to protein, suggesting increased at invasive front caused an increase tumor cells. Heparanase correlated significantly with depth invasion, lymph node metastasis, metastasis (TNM) stage lymphatic invasion. Overexpression...
Objective: The aim of this study was to evaluate atrial conduction abnormalities obtained by Doppler tissue imaging (DTI) and electrocardiogram analysis in ankylosing spondylitis (AS) patients. Methods: A total 40 patients with AS (22 males /18 females, 37.82 ± 10.22 years), 42 controls males/20 35.74 9.98 years) were included. Systolic diastolic left ventricular (LV) functions measured using conventional echocardiography DTI. Interatrial intraatrial electromechanical coupling (PA) intervals...
To investigate the existence of depression and/or anxiety with underlying risk factors among parents children classical phenylketonuria (PKU).This cross-sectional study was conducted in Division Pediatric Metabolism, Ankara Children`s Hospital, Dokuz Eylul University, Kirikkale and Erzurum Local Research Turkey, between January July 2014. Parents 61 patients 36 healthy controls completed self-report questionnaires. We used Beck Depression Inventory (BDI) to assess parental State-Trait...
Diabetes is an important reason for end-stage renal failure and diabetic foot wounds worsen the life qualities of these patients. Protein amino acid support accelerates wound healing. The purpose this retrospective study to examine effect beta-hydroxy-beta-methylbutyrate, arginine glutamine (Abound®) supplementation on A total 11 dialysis patients were included in aiming evaluate diet with healing Pre-treatment post-treatment depth appearance scored accordance "Bates-Jensen" assessment tool....
Background: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy previous reports using various endothelial markers individually suggested us investigate both normal tumor areas with a wide panel of vascular markers. Methods: Here, we used three antibodies (CD31, CD34, endoglin) as vessel the distribution properties oral tissues squamous cell carcinomas. Results: Many microvessels strong remodeling activity well undifferentiated...
We recently reported that heparanase, one of the extracellular matrix‐degrading enzymes, which plays a critical role in cancer progression, is located not only cytoplasm but also nucleus. Here we identified nuclear translocation heparanase as key step cell differentiation. applied an vitro differentiation model HL‐60 cells with 12–0‐tetradecanoylphorbol‐13‐acetate (TPA), was observed using immunohistochemical analysis. In this system, abolished by inhibitors heat shock protein 90 (HSP90),...
Increased inflammatory activity is known to be a pathophysiologic characteristic of atrial fibrillation. Familial Mediterranean fever (FMF) disease characterized by recurrent and sustained increased activity. Atrial conduction abnormalities in these patients have not been investigated terms P-wave duration, dispersion (Pd), electromechanical delay measured tissue Doppler echocardiography (TDE). We aimed assess time with FMF.A total 33 FMF (13 males/20 females, 28.4 +/- 12.5 years), controls...
Malnutrition is a common consequence of cancer in children, but the most effective methods nutrition intervention are under debate. We aimed to evaluate nutritional status children diagnosed with cancer, and investigate effect oral supplements on anthropometric measurements, biochemical parameters, outcome. A randomized clinical study 45 newly patients was performed. Anthropometric data related factors were assessed at 0, 3, 6 months after diagnosis. On initial assessment, prevalence...
Abstract Purpose: Both heparanase and cyclooxygenase-2 (COX-2) are thought to play critical roles for tumor malignancy, including angiogenesis, although it is unknown about their relationship with each other in cancer progression. We hypothesized that they may link on angiogenesis. Experimental Design: The expressions of COX-2 77 primary human esophageal tissues were assessed by immunohistochemistry do statistical analysis the correlation between clinicopathologic features, microvessel...