A5020312330- Immune Response and Inflammation
- Neonatal and Maternal Infections
- Bacterial Infections and Vaccines
- Cancer Research and Treatments
- Gut microbiota and health
- Barrier Structure and Function Studies
- Molecular Biology Techniques and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Research Data Management Practices
- Microbial Community Ecology and Physiology
- Bacterial biofilms and quorum sensing
- RNA and protein synthesis mechanisms
- Oral microbiology and periodontitis research
- Virus-based gene therapy research
- Mast cells and histamine
- Antimicrobial Peptides and Activities
- Neonatal and fetal brain pathology
- interferon and immune responses
- Genomics and Phylogenetic Studies
- Cytokine Signaling Pathways and Interactions
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
ZB MED - Information Centre for Life Sciences
2019-2025
University of Cologne
2025
University of Würzburg
2019-2022
TH Köln - University of Applied Sciences
2019
Meningococcal meningitis is a severe central nervous system infection that occurs when Neisseria meningitidis (Nm) penetrates brain endothelial cells (BECs) of the meningeal blood-cerebrospinal fluid barrier. As human-specific pathogen, in vivo models are greatly limited and pose significant challenge. In vitro cell have been developed, however, most lack critical BEC phenotypes limiting their usefulness. Human BECs generated from induced pluripotent stem (iPSCs) retain properties offer...
The Gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of adaptation to antibiotics, we analyzed transcriptome changes after 10 min exposure subinhibitory amount tetracycline (Tc). RNA-seq revealed 297 differentially expressed genes. Besides ten upregulated ribosomal genes, there was no recognizable functional pattern in the observed changes. Instead, genes were mostly first operons and often...
Bacterial meningitis is a life-threatening infection of the central nervous system (CNS) that occurs when bacteria are able to cross blood-brain barrier (BBB) or meningeal-cerebrospinal fluid (mBCSFB). The BBB and mBCSFB comprise highly specialized brain endothelial cells (BECs) typically restrict pathogen entry. Group B
spherical virus (MetSV), infecting
The capacity of Staphylococcus aureus to survive and persist within phagocytic cells has been associated with antibiotic treatment failure recurrent infections. Here, we investigated the molecular mechanisms leading S. persistence macrophages using a reporter system that enables distinguish between intracellular bacteria high low metabolic activity in combinstion dual RNA-seq approach.
Strategically located at mucosal sites, mast cells are instrumental in sensing invading pathogens and modulating the quality of ensuing immune responses depending on nature infecting microbe. It is believed that produce type I IFN (IFN-I) response to viruses, but not bacterial infections, because incapacity internalize within cells, where signaling cascades leading IFN-I production generated. However, we have previously reported that, contrast with other pathogens, Staphylococcus aureus can...
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Abstract Dual or Multi RNA-seq simultaneously analyze the transcriptomes of two more interacting species to gain insights about their interplay. The RNA is collected and sequenced together only separated in silico by mapping reads corresponding genomes. We developed READemption 2.0, our knowledge first tool that performs all necessary steps handle data from any number species. These comprise basic quality filtering adapter trimming raw reads, aligning reference genomes, generating...