A5049728418- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Respiratory Support and Mechanisms
- Alzheimer's disease research and treatments
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Sepsis Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Stress Responses and Cortisol
- Intensive Care Unit Cognitive Disorders
- Tryptophan and brain disorders
- Nosocomial Infections in ICU
- Thyroid Disorders and Treatments
- GDF15 and Related Biomarkers
- Fatty Acid Research and Health
- Phonocardiography and Auscultation Techniques
Hospital Infantil Universitario Niño Jesús
2012-2024
Instituto de Salud Carlos III
2013-2024
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2011-2024
Hospital Universitari Joan XXIII de Tarragona
2024
Menéndez Pelayo International University
2016-2021
Institut d'Investigació Sanitària Pere Virgili
2021
Centro de Investigación Biomédica en Red
2011-2021
Hospital Universitario de La Princesa
2017
Universidad Autónoma de Madrid
2011-2016
Hospital Universitari Germans Trias i Pujol
2015
Leptin and insulin have overlapping intracellular signaling mechanisms exert anorexigenic actions in the hypothalamus. We aimed to determine how chronic exposure increased leptin affects hypothalamic response a rise insulin. analyzed activation interactions of components phosphatidylinositol 3-kinase (PI3K)/Akt pathway hypothalamus rats treated icv for 14 days with followed by central injection killed 15 min later. Insulin glycemia reduced this induced glucose. decreased association between...
An excess of saturated fatty acids can be toxic for tissues, including the brain, and this has been associated with progression neurodegenerative diseases. Since palmitic acid (PA) is a free that abundant in diet circulation harmful, we have investigated effects on lipotoxicity hippocampal astrocytes mechanism involved. Moreover, as males females different susceptibilities to some diseases, accessed responses from both sexes, well possible involvement estrogens protection against toxicity....
The growth hormone (GH)/insulin-like factor I (IGF-I) axis is involved in metabolic control. Malnutrition reduces IGF-I and modifies the thermogenic capacity of brown adipose tissue (BAT). Leptin has effects on GH/IGF-I function BAT, but its interaction with mechanisms regulation thermogenesis remains unknown. We studied activation IGF-I-related signaling metabolism related to BAT chronic central leptin infused (L), pair-fed (PF), control rats. Hypothalamic somatostatin mRNA levels were...
ABSTRACT Insulin receptor substrate-2-deficient (IRS2−/−) mice are considered a good model to study the development of diabetes because IRS proteins mediate pleiotropic effects insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis cell survival. The hypothalamus might play key role in early onset diabetes, owing its involvement control glucose homeostasis energy balance. Because some inflammatory markers elevated diabetic IRS2−/− mice, our aim was analyze whether...
Alzheimer's disease (AD) is the most common form of dementia and has a higher incidence in women. The main component senile plaques characteristic AD amyloid-beta (Aβ), with surrounding astrocytes contributing to degenerative process. We hypothesized that sex difference could be partially due differential astrocytic responses Aβ. Thus, effect Aβ1-40 on cell viability, inflammatory response, oxidative status was studied cultures hippocampal from male female rats. increased astrocyte viability...
Abstract Background: Multiplexed bead immunoassays allow simultaneous measurement of adipokines and other hormones in small serum samples, although a validation this technique with classical methods has not been fully established. The purpose pilot study was to compare the characteristics multiplexed immunoassay obesity panel for insulin various methods. Methods: A performed using from 20 obese children at baseline after reducing their body mass index, 25 controls. Insulin, adiponectin,...
Insulin resistance and type 2 diabetes correlate with impaired leptin insulin signaling. receptor substrate-2 deficient (IRS2−/−) mice are an accepted model for the exploration of alterations in these signaling pathways their relationship diabetes; however, disturbances hypothalamic effect on neuropeptides controlling food intake remain unclear. Our aim was to analyze how may differentially affect expression regulating inflammation diabetic (D) nondiabetic (ND) IRS2−/− mice. We analyzed...
Leptin inhibits food intake and reduces the size of body fat depots, changing adipocyte sensitivity to insulin restrain lipid accrual. This adipokine may modulate production cytokines that could diminish sensitivity, particularly in visceral adipose tissue. To explore this possibility, we examined effects chronic central administration leptin on expression key markers metabolism its possible relationship with changes inflammatory- insulin-signaling pathways epididymal Circulating...
Several studies indicate that 17β-estradiol (E2) protects against amyloid β-peptide (Aβ)-induced cell death and activates factors associated with learning memory, a function involving the hippocampal somatostatinergic system. As alterations in somatostatin have been demonstrated Alzheimer's disease, we examined whether E2 prevents changes system induced by Aβ25-35 death, as well possible involvement of leptin insulin-like growth factor (IGF)-I signaling. We also measured levels Aβ proteases...
Insulin regulates glucose homeostasis through direct effects on the liver, among other organs, with leptin modulating insulin's hepatic actions. Since central may modify insulin signaling in we hypothesized that infusion activates glycogen synthesis following peripheral administration of a bolus or insulin, thus regulating glycemia. Oral and intraperitoneal tolerance tests were performed control, intracerebroventricular leptin-treated pair-fed rats during 14 days. An improvement glycemia an...
Obesity is an inflammatory state characterized by augment in circulating factors. Leptin may modulate the synthesis of these factors white adipose tissue decreasing insulin sensitivity. We have examined effect chronic central administration leptin on levels cytokines and possible relationship with cytokine expression protein content as well signaling subcutaneous visceral tissues. In addition, we analyzed correlation between peripheral resistance. studied 18 male Wistar rats divided into...
Dietary intervention is a common tactic employed to curtail the current obesity epidemic. Changes in nutritional status alter metabolic hormones such as insulin or leptin, well insulin-like growth factor (IGF) system, but little known about restoration of these parameters after weight loss obese subjects and if this differs between sexes, especially regarding IGF system. Here male female mice received high fat diet (HFD) chow for 8 weeks, then half HFD were changed (HFDCH) 4 weeks. Both...
Alzheimer´s disease (AD) is characterized by the brain deposition of senile plaques composed amyloid-β peptides (Aβ) that increase inflammation. An endogenous peptide derived from insulin-like growth factor (IGF)-I, glycine-proline-glutamate (GPE) has IGF-I-sensitizing and neuroprotective actions. Here, we examined effects GPE on Aβ levels hippocampal inflammation generated intracerebroventricular infusion Aβ25-35 during 2 weeks (300 pmol/day) in ovariectomized rats signaling-related...
Alzheimer’s disease (AD) is characterized by the deposition in brain of senile plaques composed amyloid-β peptides (Aβs) that increase inflammation. An endogenous peptide derived from insulin-like growth factor (IGF)-I, glycine-proline-glutamate (GPE), has IGF-I-sensitizing and neuroprotective actions. Here, we examined effects GPE on Aβ levels hippocampal inflammation generated intracerebroventricular infusion Aβ25-35 for 2 weeks (300 pmol/day) ovariectomized rats signaling-related pathways...
Prader-Willi syndrome (PWS) is associated with impaired growth hormone (GH) secretion and decreased insulin-like factor (IGF)-I levels. Pappalysins (PAPP-A, PAPP-A2) stanniocalcins (STC-1, STC-2) regulate IGF binding-protein (IGFBP) cleavage bioavailability, but their implication in PWS unknown.
Leptin modulates insulin signaling and this involves the Akt pathway, which is influenced by changes in inflammatory environment with leptin regulating cytokine synthesis. We evaluated association between activation of insulin-signaling pathway alterations pro- anti-inflammatory levels inguinal fat liver chronic central infused (L), pair-fed (PF), control rats. Signal transducer activator transcription 3 (STAT3) phosphorylation was increased reduced L Phosphorylation c-Jun N-terminal kinase...
Abstract Background Over the past decade, numerous studies on potential factors contributing to ventilation-induced lung injury have been carried out. Mechanical power has pointed out as parameter that encloses all injury-contributing factors. However, conducted date provide data regarding mechanical during early hours of ventilation may not correspond real scenario. Methods Retrospective observational study at a single center in Spain. Patients admitted intensive care unit, > o = 18...