A5025672758- Wound Healing and Treatments
- Essential Oils and Antimicrobial Activity
- Mesenchymal stem cell research
- Peripheral Artery Disease Management
- Skin Protection and Aging
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Actinomycetales infections and treatment
- Venous Thromboembolism Diagnosis and Management
- Reproductive biology and impacts on aquatic species
- Infective Endocarditis Diagnosis and Management
- Vascular Procedures and Complications
- Psoriasis: Treatment and Pathogenesis
- Abdominal vascular conditions and treatments
- Diphtheria, Corynebacterium, and Tetanus
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and Carotid Artery Diseases
- Pleural and Pulmonary Diseases
- Dermatologic Treatments and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Hair Growth and Disorders
Institute of Animal Reproduction and Food Research
2015-2024
Polish Academy of Sciences
2015-2024
Institute of Cardiology
2015-2023
Nicolaus Copernicus University
2021
Collegium Medicum in Bydgoszcz
2021
University of Bydgoszcz
2015-2017
Jan Biziel University Hospital No. 2 in Bydgoszcz
2012-2017
Pomeranian Medical University
2013
Masih Daneshvari Hospital
2004-2007
Instytut Gruźlicy i Chorób Płuc
2002
Monitoring wound progression over time is a critical aspect for studies focused on in-depth molecular analysis or evaluating the efficacy of potential novel therapies. Histopathological biopsies can provide significant insight into healing dynamics, yet there no standardized and reproducible scoring system currently available. The purpose this study was to develop statistically validate based parameters in each phase that be easily accurately assessed using either Hematoxylin & Eosin (H&E)...
Summary The value of vein ultrasonography for diagnosis symptomatic deep thrombosis (DVT) is widely accepted. We are unaware published data comparing with the “gold standard” venography DVT in asymptomatic persons patient group acutely ill medical patients. It was objective this study to evaluate sensitivity and specificity compression ultrasound (CUS) examinations proximal distal patients [with congestive heart failure (NYHA class III IV), exacerbations respiratory disease, infectious...
Triploidisation represents several advantages (e.g. sterility) and therefore is routinely applied in aquaculture of commercially important fish species, including rainbow trout. The comparative transcriptomic analysis ovaries triploid (3N) diploid (2N) female trout revealed a total 9 075 differentially expressed genes (DEGs; 4 105 upregulated 2N 970 3N ovaries, respectively). Identified clusters for DEGs were different, carbohydrate lipid metabolic process transport, protein modification,...
Psoriasis vulgaris is a genetically heterogenous disease with unclear molecular background. We assessed the association of psoriasis and its main clinical phenotypes common variants three potential susceptibility genes: ZNF750, RPTOR TRAF31P2. genotyped 10 in cohort 1,034 case-control individuals using Taqman genotyping assays sequencing. Minor alleles all four TRAF3IP2 were more frequent among cases. The strongest, significant was observed for rs33980500 (OR = 2.5, p 0.01790). allele this...
Dermal white adipose tissue (dWAT) is involved in the maintenance of skin homeostasis. However, studies concerning its molecular regulation are limited. In present paper, we ask whether introduction two transcription factors, Foxn1 and Hif-1α, into post-wounded Foxn1-/- mice regulates dWAT during wound healing (days 3 6). We have chosen lentivirus vectors (LVs) as a tool to deliver Hif-1α skin. documented that combinations both transgenes reduces number, size diameter dermal adipocytes at...
SUMMARY A population of adult stem cells responsible for cyclic reconstructing and remodeling has been proposed to reside in the highly regenerative mammalian endometrium. Recently, stem/progenitor have identified human mouse endometrium, but less is known about these livestock animals. Using Hoechst 33342 fluorescent dye staining flow cytometry, we an emerging cell side that may be regeneration process porcine The percentage side‐population on Day 19 estrous cycle was significantly higher...
Skin exposed to environmental threats, including injuries and oxidative stress, develops an efficient but not fully recognized system of repair antioxidant protection. Here, using mass spectrometry analysis (LC–MS/MS), followed by in vitro vivo experiments, we provided evidence that Foxn1 keratinocytes regulates elements the electron transport chain participates thioredoxin (Txn2, Txnrd3, Srxn1) induction, particularly a hypoxic environment. We first showed upregulates glutathione reductase...
The primary mechanism by which adipose-derived stem cells (ASCs) exert their reparative or regenerative potential relies predominantly on paracrine action. Secretory abilities of ASCs have been found to be amplified hypoxia pre-conditioning. This study investigates the impact (1% O2) secretome composition pig (pASCs) and explores effect pASCs’ conditioned media (CM) skin cell functions in vitro expression markers attributed wound healing. Exposure pASCs increased levels vascular endothelial...
BACKGROUND: Inflammatory responses mediated by adipocytokines may affect both atherosclerosis development and progression, as well the risk of in-stent restenosis. The aim this study was to determine relationships between blood leptin, adiponectin tumor necrosis factor-α (TNF-α) concentrations 1-year outcome superficial femoral artery (SFA) stenting.METHODS: Blood TNF-α were determined in 70 patients undergoing SFA stenting due intermittent claudication 40 carotid (CAS). All subjects...
In birds, the zona pellucida (ZP) matrix that surrounds ovulated oocyte-called inner perivitelline layer-is involved in sperm-zona interaction and successful fertilization. To identify important genes proteins connected with final step of egg development, next-generation sequencing two-dimensional electrophoresis, combined mass spectrometry, were used for analysis mature oocytes at F1 developmental stage. A total 8161 228 annotated. Six subfamilies genes, codes ZP, ZP1-4, ZPD, ZPAX,...
Adipose-derived stem cells (ASCs) from human and animal fat have emerged as therapeutic alternatives for damaged tissues. Pre-conditioning of ASCs with hypoxia results in their functional enhancement, which might facilitate the process healing. However, there is still a critical need large-scale preclinical studies to reinforce translation these findings into clinical practice humans veterinary medicine. Here, we adapted full-thickness excisional skin wound mouse model evaluate compare...
The tissue-specific profile of alternatively spliced genes ( ASGs ) and their involvement in reproduction processes characteristic turkey testis, epididymis, ductus deferens were investigated for the first time birds. Deep sequencing male reproductive tissue RNA samples (n = 6) was performed using Illumina RNA-Seq with 2 independent methods, rMATs SUPPA2, differential alternative splicing DAS event prediction. expression selected validated quantitative real-time reverse...
The outcome of endovascular therapy can be influenced by a number factors, either demographic, biochemical, angiographic or procedural. Knowledge about these factors may help in the individualization therapeutic methods, surveillance intensity, and should, ultimately, improve intervention efficacy.The aim this study was to estimate effect clinical biochemical on late lower limb artery stenting.The medical documentation 91 patients with at least 1 year follow-up after stenting retrospectively...
About 20-30% of the population have peripheral artery disease. Many them require intervention, with a percutaneous procedure currently being first choice. However, outcomes these interventions need regular evaluation due to continuous progress in endovascular techniques and devices used.The aim this study was analyze procedural factors influencing outcome intervention patients stented for time lower extremity atherosclerosis.The medical documentation 91 at least 1 year follow-up after...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Budzyński J, Wiśniewska Wasielewski M, Suppan K. Original paperThe effect of superficial femoral artery stenting and some atherosclerosis risk factors on changes in selected global endothelial function tests patients with chronic lower limb ischemia. A pilot study. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2012;8(3):205-215. doi:10.5114/pwki.2012.30400. APA Budzyński, J.,...
Previous studies have suggested that immune mechanisms contribute to lung injury in cystic fibrosis (CF); however, there been no comprehensive of immunofluorescent staining patterns CF tissue. We performed immunofluorescence (IF) for immunoglobulins, C3, and fibrinogen on autopsy frozen tissue from 21 patients. Results were compared with findings patients without CF. In CF-derived was ubiquitous along the alveolar wall, space, interstitium. Free immunoglobulin G (IgG) IgA coated surface...
Abstract Intradermal adipocytes form dermal white adipose tissue (dWAT), a unique fat depot localized in the lower layer of dermis. However, recognition molecular factors regulating dWAT development, homeostasis, and bioactivity is limited. Using Foxn1 −/− +/+ mice, we demonstrated that epidermally expressed regulates development defines adipogenic capacity fibroblasts. In intact post‐wounded skin, contributes to initial stimulation adipogenesis participates modulation lipid metabolism...
Follow-up studies of psoriasis patients indicate an increased risk in the occurrence malignancies at different sites origin. Population stratification and/or complicated interpretation evidence on cancer (due to small number included most series) lead inconsistent data. Herein we investigated origin a series 517 and their 1st degree relatives.We evaluated tumour spectrum as well age patient diagnosis cancers families along with observed expected frequencies malignancies. The distribution 17...
Introduction. Therapeutical, cosmetical and culinary properties of lavender oil was valued from ancient. Lavandula angustifolia Mill. (Lavandula officinalis Chaix.) belonging to the family Lamiaceae. Lavender produced essential oil. It possess different property: hepatoprotective, antidiabetic, antispasmotic, antiulcers, antidepression, antioxidant, antireumatic, insect repellent antimicrobial. Aim. The aim this work investigate susceptibility anaerobes oral cavity Material methods....