A5101904359- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Peroxisome Proliferator-Activated Receptors
- Solar and Space Plasma Dynamics
- Fatty Acid Research and Health
- Cancer, Hypoxia, and Metabolism
- Astro and Planetary Science
- Stellar, planetary, and galactic studies
- Metabolism, Diabetes, and Cancer
- Neuroscience and Neuropharmacology Research
- Antioxidant Activity and Oxidative Stress
- Synthesis and bioactivity of alkaloids
- Regulation of Appetite and Obesity
- Analytical Chemistry and Chromatography
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Chemical Reaction Mechanisms
- Vitamin C and Antioxidants Research
- Berberine and alkaloids research
- Ionosphere and magnetosphere dynamics
- Retinoids in leukemia and cellular processes
- Coenzyme Q10 studies and effects
- Exercise and Physiological Responses
- Cancer therapeutics and mechanisms
Universitat de Barcelona
1998-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2007-2010
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2010
Centre National de la Recherche Scientifique
2005-2009
Hôpital Rangueil
2005-2009
Université Toulouse III - Paul Sabatier
2005-2009
Hospital Clínic de Barcelona
2007
Hospital de Clínicas "José de San Martín"
1998
Universidad de Sevilla
1987-1993
Abstract In contrast to the earlier contention, adult humans have been shown recently possess active brown adipose tissue with a potential of being metabolic significance. Up now, fat precursor cells not available for human studies. We previously that multipotent adipose-derived stem (hMADS) exhibit normal karyotype and high self-renewal ability; they are known differentiate into key properties white adipocytes, is, uncoupling protein two expression, insulin-stimulated glucose uptake,...
Abstract Brown adipose tissue uncoupling protein-1 (UCP1) plays a major role in the control of energy balance rodents. It has long been thought, however, that there is no physiologically relevant UCP1 expression adult humans. In this study we show, using an original approach consisting sorting cells from various tissues and differentiating them adipogenic medium, stationary population skeletal muscle expressing CD34 surface protein can differentiate vitro into genuine brown adipocytes with...
The recently identified uncoupling protein-3 (UCP-3) gene, predicted to encode a new member of the family proteins, is preferentially expressed in skeletal muscle and has been related phenotypes obesity type 2 diabetes. We have established that during mouse ontogeny, expression UCP-3 gene switched on just after birth. induction dependent initiation suckling particularly lipid intake. Treatment newborn mice with activators peroxisome proliferator-activated receptors (PPARs), such as...
Current antidepressants, which inhibit the serotonin transporter (SERT), display limited efficacy and slow onset of action. Here, we show that partial reduction SERT expression by small interference RNA (SERT-siRNA) decreased immobility in tail suspension test, displaying an antidepressant potential. Moreover, short-term SERT-siRNA treatment modified mouse brain variables considered to be key markers action: reduced function 5-HT1A-autoreceptors, elevated extracellular forebrain increased...
The Extreme Ultraviolet Imager (EUI) on board the Solar Orbiter (SO) spacecraft observed small extreme ultraviolet (EUV) bursts, termed campfires, that have been proposed to be brightenings near apexes of low-lying loops in quiet-Sun atmosphere. underlying magnetic processes driving these campfires are not understood. During cruise phase SO and at a distance 0.523\,AU from Sun, Polarimetric Helioseismic (SO/PHI) region jointly with SO/EUI, offering possibility investigate surface field...
Uncoupling protein‐3 gene expression in skeletal muscle is up‐regulated during postnatal development of mice. A high‐carbohydrate diet at weaning induces a decrease uncoupling mRNA levels that does not occur when mice were weaned onto high‐fat diet. do increase response to fasting young pups. Only after day 15 life, increases serum non‐esterified fatty acids, by starvation. Over‐nutrition or under‐nutrition lactation decreases, respectively, muscle. Regulation mediated ontogenic and...
C/EBPβ (CCAAT/enhancer-binding protein β) is a transcriptional regulator of the UCP1 (uncoupling protein-1) gene, specific marker gene brown adipocytes that responsible for their thermogenic capacity. To investigate role in fat, we studied C/EBPβ-null mice. When placed cold, C/EBPβ−/− mice did not maintain body temperature. This cold-sensitive phenotype occurred, although and PGC-1α (peroxisome-proliferator-activated receptor γ co-activator-1α) expression was unaltered fat The promoter...
Brown fat differentiation in mice is fully achieved fetuses at term and entails the acquisition of not only adipogenic but also thermogenic oxidative mitochondrial capacities. The present study homozygous for a deletion gene CCAAT/enhancer-binding protein α (C/EBPα-null mice) demonstrates that C/EBPα essential all these processes. Developing brown from C/EBPα-null showed lack uncoupling protein-1 expression, impaired adipogenesis, reduced size number mitochondria per cell when compared with...
The expression of uncoupling protein (UCP)-3 mRNA in skeletal muscle is dramatically reduced during lactation mice. reduction UCP-3 levels lowers the amount mitochondria lactation. Spontaneous or abrupt weaning reverses downregulation but not levels. In lactating and virgin mice, however, fasting increases Changes occur parallel with modifications free fatty acids, which are upregulated due to fasting. Modifications energy nutritional stress dams achieved by manipulating litter sizes do...
Context. Traditionally, the observation time needed to build synoptic maps of solar magnetic field is bound 27 days a full Carrington rotation due single viewpoint from Earth. Aims. Our aim reduce this 13.5 by combining magnetograms two vantage points, 180° apart in longitude ideal case. Methods. We combined observations taken Polarimetric and Helioseismic Imager (SO/PHI) during superior conjunction Solar Orbiter February 2021 with data Magnetic (SDO/HMI) constructed map line-of-sight CR...
The developmental regulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) gene expression was studied in mice and compared with that marker genes liver energy metabolism. PGC-1α highly expressed fetal adults remained high neonatal liver. during the early periods dissociated from gluconeogenic genes, i.e. phosphoenolpyruvate carboxykinase (PEPCK) glucose-6-phosphatase (G6Pase) genes. Only under effects starvation induced parallel to G6Pase mRNAs perinatal period....
The expression of uncoupling protein‐2 (UCP2) mRNA is up‐regulated during the differentiation brown adipocytes in primary culture. When impaired, UCP2 down‐regulated. 9‐ cis Retinoic acid causes a dose‐dependent induction levels adipocytes, whereas all‐ trans retinoic has no effect. Specific agonists retinoid X receptors (RXR) induce expression, specific activators do not. acid, acting through RXR receptors, identified as major regulator gene fat cell.
Sodium tungstate is an anti-obesity drug targeting peripheral tissues. In vivo, sodium reduces body weight gain and food intake through increasing energy expenditure lipid oxidation, but it also modulates hypothalamic gene expression when orally administered, raising the possibility of a direct effect on central nervous system.Sodium was administered intraperitoneally (ip) to Wistar rats, its levels were measured in cerebrospinal fluid mass spectrometry. Body monitored for 24 h after...
Due to the importance of fat tissues in both energy balance and associated disorders arising when such is not maintained, adipocyte differentiation has been extensively investigated order control inhibit enlargement white adipose tissue. The ability a cell undergo one particular feature all mesenchymal cells. Up until now, peroxysome proliferator-activated receptor (PPAR) subtypes appear be keys essential players capable inducing controlling differentiation. In addition, it now accepted that...