A5042315511- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- RNA and protein synthesis mechanisms
- Microplastics and Plastic Pollution
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Energy and Environment Impacts
- Recycling and Waste Management Techniques
- Genomics and Phylogenetic Studies
- Plant and Biological Electrophysiology Studies
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Mass Spectrometry Techniques and Applications
- Graphene and Nanomaterials Applications
- Crystallography and molecular interactions
- Plant biochemistry and biosynthesis
- Glutathione Transferases and Polymorphisms
- Plant Reproductive Biology
- Peptidase Inhibition and Analysis
- Nanocluster Synthesis and Applications
- Anesthesia and Neurotoxicity Research
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
Wuhan Institute of Technology
2024
Hong Kong Baptist University
2010-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Xiamen University
2021-2023
Hong Kong University of Science and Technology
2013-2020
University of Hong Kong
2013-2020
HKUST Shenzhen Research Institute
2018-2020
Zhejiang Ocean University
2020
Jiamusi University
2012-2016
-Phenylenediamines (PPDs) have been extensively used in the rubber industry and found to be pervasive various environmental compartments for decades, while their transformation products associated ecological human health risks remain largely unknown. Herein, we developed implemented a mass spectrometry-based platform combined with self-synthesized standards investigation of rubber-derived quinones formed from PPD antioxidants. Our results demonstrated that five are ubiquitously present urban...
Plastic debris in the global biosphere is an increasing concern, and nanoplastic (NPs) toxicity humans far from being understood. Studies have indicated that NPs can affect mitochondria, but underlying mechanisms remain unclear. The liver lungs important metabolic functions are vulnerable to NP exposure. In this study, we investigated effects of 80 nm on mitochondrial pathways normal human hepatic (L02) cells lung (BEAS-2B) cells. exposure did not induce mass cell death; however,...
-Phenylenediamine quinones (PPD-Qs) are a newly discovered class of transformation products derived from
Fine particulate matter (PM 2.5 ) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM components to toxicity, especially considering regional disparities. Moreover, prevention solutions -associated health effects are scarce. In present study, we comprehensively characterized and compared primary constituents their altered metabolites from two locations: Taiyuan Guangzhou. Analysis year-long samples revealed 84...
Wastewater treatment plants (WWTPs) converge multiple sourced microplastics (MPs) and serve as a temporary repository in the case of releasing them into environment. The process involves two critical scientific problems, including source composition MPs their fate WWTPs. Therefore, this study conducted full-scale investigation each stage four WWTPs Hong Kong, with results showing that was mainly affected by physicochemical characteristics WWTP parameters. Moreover, three conventional machine...
Ethylene is an important plant hormone that regulates numerous cellular processes and stress responses. The mode of action ethylene both dose- time-dependent. Protein phosphorylation plays a key role in signaling, which mediated by the activities receptors, constitutive triple response 1 (CTR1) kinase, phosphatase. To address how alters protein profile time-dependent manner, differential quantitative phosphoproteomics based on (15)N stable isotope labeling Arabidopsis was performed...
Cadmium is a well-known hazardous pollutant that mainly comes from dietary, tobacco and occupational exposure, posing threat to kidney. However, there still lack of systematic study on metabolic pathways urinary biomarkers related its nephrotoxicity under cadmium exposure for both females males. In this study, mass spectrometry-based metabolomics investigation cohort 144 volunteers was conducted explore sex-specific alteration screen cadmium-induced nephrotoxicity. When the concentration...
Inhalation of fine particulate matter PM2.5-bound arsenic (PM2.5-As) may cause significant cardiovascular damage, due to its high concentration, long transmission range, and good absorption efficiency in organisms. However, both the contribution effect exposure pathway, with PM2.5 as medium, on system damage nonferrous smelting sites remain be studied. In this work, a one-year site sample collection analysis work showed that annual concentration PM2.5-As reached 0.74 μg/m3, which was 120...
Driven by the global popularity of electric vehicles and shortage critical raw materials for batteries, spent lithium-ion power battery (LIPB) recycling industry has exhibited explosive growth in both quantity scale. However, relatively little information is known about environmental risks posed LIPB recycling, particular with regards to perfluoroalkyl polyfluoroalkyl substances (PFAS). In this work, suspect screening nontarget analysis were carried out characterize PFAS soil, dust, water...
The ubiquitous presence of micro/nanoplastics (MP/NP) in the atmosphere has raised significant concerns about their potential health risks through inhalation, yet effects natural respiratory exposure remain underexplored. This study addresses this critical knowledge void by utilizing a whole-body inhalation system to investigate distribution, accumulation, and pulmonary toxicity polystyrene MP/NP (1.5 × 105 particles/m3) male ICR mice (n = 16/group). Fluorescently labeled revealed highest...
Significance Plants respond to a delicate force signal, such as light touch, similar animal neural systems, demonstrated by thigmotropism, thigmonastic movement, and thigmomorphogenesis. To understand the force-signaling networks, we applied stable isotope labeling in Arabidopsis (SILIA)-based quantitative posttranslational modification proteomics assess protein phosphorylation changes subjected 40-second cotton-swab identified 4,895 nonredundant phosphopeptides, 579 of which are previously...
The flexible and controlled synthesis of metal–organic framework (MOF)-derived hybrid nanostructures is great significance in fine tuning their enrichment performance large-scale in-depth phosphoproteome analysis. Herein, a magnetic guanidyl-functionalized MOF coating with multiaffinity sites, denoted as Fe3O4@G-ZIF-8, was fast fabricated via one-pot epitaxial growth strategy for the first time applied selective highly efficient global phosphopeptides. intrinsic unsaturated metal sites ZIF-8...
Cadmium (Cd) pollution reduces rice production and quality, putting food security human health at risk. We conducted comparative physiology metabolomic analyses in two indica ('NH199' 'NH224') to elucidate the Cd-tolerance mechanism. Cd hampered growth, induced oxidative stress, changed metabolomics profiling of root. The biochemical physiological analysis demonstrated that NH224 exhibited a more potent ability than NH199. was primarily distributed root, had lower translocation factor NH199...
High-fructose diet-fed rats as one of the insulin resistant models was used widely for understanding mechanisms type 2 diabetes mellitus. Systems-level metabolic profiling rat model, however, has not been deciphered clearly. To address this issue, mass spectrometry-based metabolomics employed to unlock snapshots oral glucose tolerance test (oGTT) effect in either healthy or diabetic rats, well delineate signatures tissues fed with high-fructose diet. Several differentiating metabolites were...
Protein acetylation, one of many types post-translational modifications (PTMs), is involved in a variety biological and cellular processes. In the present study, we applied both CsCl density gradient (CDG) centrifugation-based protein fractionation dimethyl-labeling-based 4C quantitative PTM proteomics workflow study dynamic acetylproteomic changes Arabidopsis. This integrates dimethyl chemical labeling with chromatography-based acetylpeptide separation enrichment followed by mass...
The COVID-19 pandemic has incurred tremendous costs worldwide and is still threatening public health in the “new normal.” association between neutralizing antibody levels metabolic alterations convalescent patients with poorly understood. In present work, we conducted absolutely quantitative profiling to compare plasma cytokines metabolome of ordinary antibodies (CA), convalescents rapidly faded (CO), healthy subjects. As a result, identified that such as M-CSF IL-12p40 metabolites...
Epidemiology has associated fine particulate matter (PM2.5) exposure with an increased cardiovascular risk. However, the underlying mechanism, particularly from liver perspective, remains unclear. Here, influence of chronic PM2.5 on risk in mice fed a high-fat and high-cholesterol diet (HFCD) was studied by using real-world system. Results showed that elevated serum levels nonhigh-density lipoprotein cholesterol (non-HDL-C) oxidized low-density (oxLDL) HFCD-fed mice, demonstrating To...