A5056916467- Malaria Research and Control
- Global Public Health Policies and Epidemiology
- Complement system in diseases
- Ferroelectric and Negative Capacitance Devices
- Plant Molecular Biology Research
- Mosquito-borne diseases and control
- Ferroelectric and Piezoelectric Materials
- Global Maternal and Child Health
- Drug Transport and Resistance Mechanisms
- Healthcare Systems and Reforms
- Epilepsy research and treatment
- Plant-Microbe Interactions and Immunity
- Legume Nitrogen Fixing Symbiosis
- Pharmacological Effects and Toxicity Studies
- Psychosocial Factors Impacting Youth
- Acoustic Wave Resonator Technologies
- Photosynthetic Processes and Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Machine Learning and Data Classification
- Liver Disease Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
- MXene and MAX Phase Materials
- Light effects on plants
Pusan National University
2014-2025
The University of Sydney
2023-2025
Seoul National University
2019-2023
SK Group (South Korea)
2022-2023
Children's Medical Research Institute
2023
Gates Foundation
2016-2021
University Health Network
2011-2017
University of Toronto
1998-2017
Toronto General Hospital
2011-2017
Ewha Womans University Medical Center
2017
Abstract This work investigates the evolution of ferroelectric (FE) performance sputtered aluminum scandium nitride (AlScN) thin film, which has a high remanent polarization ( P r , > 100 µC cm −2 ) and coercive field E c 6 MV −1 ), with electric cycling. The aims at elucidating underlying origin severe fatigue behavior, even relatively small number endurance cycles (<10 5 ). When cycled low field, an internal is created by charges trapped between FE layer interfacial dielectric...
Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly Staphylococcus aureus and Streptococcus pyogenes. TSS characterized aberrant activation of T cells excessive release pro-inflammatory cytokines ultimately resulting in capillary leak, septic shock, multiple organ dysfunction high mortality rates. No therapeutic or vaccine has been approved the U.S. Food Drug Administration for TSS, novel strategies improve clinical...
miR-155 has been shown to participate in host response infection and neuro-inflammation via negative regulation of blood-brain-barrier (BBB) integrity T cell function. We hypothesized that may contribute the pathogenesis cerebral malaria (CM). To test this hypothesis, we used a genetic approach modulate expression an experimental model (ECM). In addition, engineered endothelialized microvessel system serum samples from Ugandan children with CM were examine anti-miR-155 as potential...
### Summary box One formidable barrier to equity in the global health field is its implicit function of legitimising and reproducing existing power structure addition explicit goal improving population equity. In October 2019, Johns Hopkins Bloomberg School Public Health, Nuclear Threat Initiative, Economist Intelligence Unit published Global Health Security Index.1 An international advisory panel ‘21 experts from 13 countries ranked 195 based on a comprehensive framework 140 questions,...
Abstract Ferroelectric aluminum scandium nitride (Al 0.7 Sc 0.3 N) has attracted increasing interest due to its high remanent polarization ( P r , >100 µC cm −2 ) and coercive field E c >5 MV −1 ). The four radio frequency reactive magnetron sputtering conditions (sputtering power, N 2 flow ratio, pressure, temperature) influence the ferroelectric material properties of 45 nm‐thick Al deposited on TiN/SiO /Si substrate. Crystallinity is enhanced under deposition with higher adatom...
The host immune response contributes to the onset and progression of severe malaria syndromes, such as cerebral malaria. Adjunctive immunomodulatory strategies for may improve clinical outcome beyond that achievable with artemisinin-based therapy alone. Here, we report prophylaxis inhaled nitric oxide significantly reduced systemic inflammation (lower TNF, IFNγ MCP-1 in peripheral blood) endothelial activation (decreased sICAM-1 vWF, increased angiopoeitin-1 levels an experimental model....
Rationale Severe influenza remains a major public health threat and is responsible for thousands of deaths annually. Increasing antiviral resistance limited effectiveness current therapies highlight the need new approaches to treatment. Extensive pre-clinical data have shown that mesenchymal stromal (stem) cell (MSC) therapy can induce anti-inflammatory effects enhance repair injured lung. We hypothesized MSC would improve survival, dampen lung inflammation decrease acute injury (ALI) in...
Severe malaria remains a major cause of childhood mortality globally. Decreased endothelial nitric oxide is associated with severe and fatal malaria. The hypothesis was that adjunctive inhaled (iNO) would improve outcomes in African children A randomized, blinded, placebo-controlled trial iNO at 80 ppm by non-rebreather mask versus room air placebo as treatment to artesunate conducted. primary outcome the longitudinal course angiopoietin-2 (Ang-2), an biomarker severity clinical outcome. One...
Chemotherapy often kills a large fraction of cancer cells but leaves behind small population drug-tolerant persister cells. These survive drug treatments through reversible, non-genetic mechanisms and cause tumour recurrence upon cessation therapy. Here, we report tolerance mechanism regulated by the germ-cell-specific H3K4 methyltransferase PRDM9. Through histone proteomic, transcriptomic, lipidomic, ChIP-sequencing studies combined with CRISPR knockout phenotypic screen, identified that...
ABSTRACT The host immune response plays an important role in the onset and progression of cerebral malaria (CM). complement system is essential component innate to malaria, its activation generates anaphylatoxin C5a. To test hypothesis that C5a signaling contributes pathogenesis CM, we investigated a causal for receptors C5aR C5L2 mouse model experimental CM (ECM) induced by Plasmodium berghei ANKA infection, using case-control design, examined levels plasma samples from Ugandan children...
The in utero environment profoundly impacts childhood neurodevelopment and behaviour. A substantial proportion of pregnancies Africa are at risk malaria pregnancy (MIP) however the impact exposure to MIP on fetal is unknown. Complement activation, particular C5a, may contribute neuropathology adverse outcomes during MIP. We used an experimental model standardized neurocognitive testing, MRI, micro-CT HPLC analysis neurotransmitter levels, test hypothesis that alters through a C5a-C5aR...
Abstract Background Severe falciparum malaria (SM) pathogenesis has been attributed, in part, to deleterious systemic host inflammatory responses infection. High mobility group box 1 (HMGB1) protein is an important mediator of inflammation implicated sepsis pathophysiology. Methods Plasma levels HMGB1 were quantified a cohort febrile Ugandan children with Plasmodium infection, enrolled prospective observational case-controlled study, using commercial enzyme-linked immunosorbent assay. The...
Abstract Background. Host responses to infection are critical determinants of disease severity and clinical outcome. The development tools risk stratify children with malaria is needed identify most likely benefit from targeted interventions. Methods. This study investigated the kinetics candidate biomarkers mortality associated endothelial activation dysfunction (angiopoietin-2 [Ang-2], soluble FMS-like tyrosine kinase-1 [sFlt-1], intercellular adhesion molecule-1 [sICAM-1]) inflammation...
► The existing reports tend to portray the effective interventions and policies as if they operate independently of surrounding political social processes.As a result, these have limited insights public health value for diverse system contexts, especially more resource-constrained settings.► In times global pandemic an unprecedented scale that has shaken human societies profoundly COVID-19 has, it is urgent us collectively challenge ourselves think beyond business-as-usual mode imagine new...
Abstract Ti layer inserted in the TiN gate electrode effectively scavenges oxygen low‐ k interfacial SiO 2 of metal–ferroelectric–insulator–semiconductor (MFIS) capacitors with ferroelectric Al‐doped HfO (HAO) thin film. The scavenging effect increases remanent polarization (P r ) and reduces coercive voltage (V c capacitance equivalent thickness (CET) HAO films, particularly when MFIS capacitor is annealed at 800 °C. Additionally, frequency dispersion characteristics interface trap density...
Background: The current approach to global health has significantly contributed improving it, as evidenced by the progress made toward Millennium Development Goals (MDGs). However, gains achieved are often highly unequitable, and is expected be insufficient meet future equity challenges. There an urgent need re-think expand scope of research programmatic strategies.Objective: This paper aims assess ideological underpinnings currently dominant norms in health, with goal highlighting areas...