A5053640365- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Diabetes Management and Research
- Fatty Acid Research and Health
- Statistical Methods and Inference
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic function and diabetes
- Venous Thromboembolism Diagnosis and Management
- Natural Products and Biological Research
- Cardiovascular Function and Risk Factors
- Nutritional Studies and Diet
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes and associated disorders
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Heart Failure Treatment and Management
- Statistical Methods and Bayesian Inference
- Blood transfusion and management
- Cardiac Imaging and Diagnostics
- Complex Systems and Time Series Analysis
- Retinal Diseases and Treatments
- Genetic and phenotypic traits in livestock
- Metabolism, Diabetes, and Cancer
Novo Nordisk (Denmark)
2018-2024
Aalborg University Hospital
2007-2018
Aalborg University
2006-2016
University of Birmingham
2015-2016
Birmingham City Hospital
2015-2016
Thrombosis Research Institute
2014
Aarhus University Hospital
2007-2013
The University of Melbourne
2013
Aarhus University
2009-2012
Svendborg Sygehus
2012
The CHA2DS2-VASc score (congestive heart failure, hypertension, age ≥75 years [doubled], diabetes, stroke/transient ischemic attack/thromboembolism vascular disease [prior myocardial infarction, peripheral artery disease, or aortic plaque], 65-75 years, sex category [female]) is used clinically for stroke risk stratification in atrial fibrillation (AF). Its usefulness a population of patients with failure (HF) unclear.To investigate whether predicts stroke, thromboembolism, and death cohort...
Background— Intracranial hemorrhage is the most feared complication of oral anticoagulant treatment. The optimal treatment option for patients with atrial fibrillation who survive an intracranial remains unknown. We hypothesized that restarting was associated a lower risk stroke and mortality in comparison not restarting. Methods Results— Linkage 3 Danish nationwide registries period between 1997 2013 identified on incident hemorrhage. Patients were stratified by regimens (no treatment, or...
Summary In data sets with many more features than observations, independent screening based on all univariate regression models leads to a computationally convenient variable selection method. Recent efforts have shown that, in the case of generalized linear models, may suffice capture relevant high probability, even ultrahigh dimension. It is unclear whether this formal sure property attainable when response right-censored survival time. We propose very efficient method for which can be...
To evaluate effectiveness and safety of rivaroxaban versus warfarin or dabigatran etexilate in a prospective cohort routine care non-valvular atrial fibrillation (AF) patients during February 2012 to August 2014.We identified nationwide health registries AF who were new-users 15 mg (R15) 20 (R20); 110 (D110) 150 (D150); warfarin. Propensity-adjusted Cox regression was used compare outcome rates four settings: 'R15 vs. warfarin'; D110'; 'R20 D150'.Rivaroxaban users (R15: n = 776; R20: 1629)...
For survival data with a large number of explanatory variables, lasso penalized Cox regression is popular regularization strategy. However, model may not always provide the best fit to and can be difficult estimate in high dimension because its intrinsic nonlinearity. The semiparametric additive hazards flexible alternative which natural analogue standard linear model. Building on this analogy, we develop cyclic coordinate descent algorithm for fitting elastic net requires no nonlinear...
Principal component analysis (PCA) has been used extensively in the field of nutritional epidemiology to derive patterns that summarize food and nutrient intake, but interpreting it can be difficult. The authors propose use a new statistical technique, treelet transform (TT), as an alternative PCA. TT combines quantitative pattern extraction capabilities PCA with interpretational advantages cluster produces involving only naturally grouped subsets original variables. compared derived using...
Recent data suggest that β-blockers are associated with prognostic advantages in heart failure (HF) patients without concomitant atrial fibrillation (AF), but not HF AF. We aimed to investigate associations between β-blocker treatment and cardiovascular outcome mortality AF HF.Three nationwide registries were used identify nonvalvular or HF. Patients stratified into users nonusers, according the presence of a diagnosis. followed ≤ 5 years after baseline. Six different outcomes investigated,...
Background and Purpose— The CHA 2 DS VASc score the Essen Stroke Risk Score are respectively used for risk stratification in patients with atrial fibrillation cerebrovascular incidents. We aimed to test ability of scores predict stroke recurrence, death, cardiovascular events (stroke, transient ischemic attack, myocardial infarction, or arterial thromboembolism) a nationwide Danish cohort study, among incident no fibrillation. Methods— conducted registry-based study Patients were stratified...
The purpose was to elucidate the association between parity and incidence of diabetes using national register data.The study population consisted all Danish women with a singleton delivery in 1982/1983 (n = 100,669), who subsequently had 74,966 deliveries. included were followed up via registries until end 2006 for subsequent deliveries, diagnosis death/emigration.A total 2021 cases (2.0%) diagnosed connection hospitalization or outpatient treatment during follow-up. Analyses adjusted fetal...
The objective of the present retrospective study was to assess long-term morbidity and postoperative complications after autogenous bone harvesting from ascending mandibular ramus.Bone ramus conducted in a consecutive case series, including 325 patients, at Department Oral Maxillofacial Surgery, Aalborg University Hospital, Denmark January 1, 2000 December 31, 2010. Records radiographs were retrospectively analyzed.Temporary neurosensory disturbances inferior alveolar nerve found 6.1%...
Patients with end-stage renal disease (ESRD) have an increased mortality from cardiovascular (CVD). N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is independent predictor of in patients ischemic heart and congestive failure. Previous data shown markedly elevated levels NT-pro-BNP ESRD, while the prognostic value ESRD largely unknown. The aim present study was to examine if level predicts ERSD CVD.We prospectively followed 206 documented CVD. Levels were measured at baseline, for 2...
Several population-based studies have reported blood glucose levels and pressure to be risk factors for the development of diabetic retinopathy. These were initiated more than two decades ago may therefore reflect treatment population composition a previous era, suggesting new present with diabetes.This cross-section study included 656 people type 1 diabetes 328 2 diabetes. Crude prevalence rates proliferative retinopathy, clinically significant macular oedema several specific retinal...
Abstract Background The few published studies on caries among childhood cancer survivors are small and their results conflicting. study aim was to examine the risk of dental children who have survived cancer. Procedure We included 299,426 7‐year‐old, 313,461 12‐year‐old, 301,930 15‐year‐old born between 1984 1988 in a nationwide population‐based linking records from Danish Cancer Registry with national database oral health. Children whose examinations had been preceded by diagnosis (288 459...
The treelet transform is a recent data reduction technique from the field of machine learning. Sharing many similarities with principal component analysis, can reduce multidimensional dataset to projections on small number directions or components that account for much variation in original data. However, contrast produces sparse components. This greatly simplify interpretation. I describe tt Stata add-on performing transform. addon includes Mata implementation algorithm alongside other...
The aim of this study was to investigate whether there is a similar mortality and thrombo-embolic risk, after an atrial ablation procedure, compared with fibrillation (AF) procedure.Using data from nationwide Danish health registries, we identified patients aged 18-75 years undergoing first-time flutter or AF procedure in the period 2000-13. Cox proportional hazards regression used calculate hazard ratios (HRs) 5 follow-up, adjusting for concomitant risk factors. A total 1096 2266 underwent...
To compare the effects of semaglutide 1.0 mg versus dulaglutide 3.0 and 4.5 on HbA1c body weight in patients with type 2 diabetes.A Bucher indirect comparison was conducted to efficacy outcomes using published results from SUSTAIN 7 AWARD-11 trials. Sensitivity analyses individual patient data aggregate were explore impact adjustment for cross-trial imbalances baseline characteristics.Semaglutide significantly reduced mg, an estimated treatment difference (ETD) -0.24%-points (95% confidence...