A5053170787- Intracranial Aneurysms: Treatment and Complications
- Fibroblast Growth Factor Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Semiconductor Quantum Structures and Devices
- Cerebrovascular and Carotid Artery Diseases
- Proteoglycans and glycosaminoglycans research
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer-related Molecular Pathways
- Metabolism and Genetic Disorders
- Semiconductor materials and interfaces
- Semiconductor materials and devices
- Carbohydrate Chemistry and Synthesis
- Terahertz technology and applications
- Microwave-Assisted Synthesis and Applications
- Hair Growth and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
Tokyo Institute of Technology
2005-2024
National Institute of Advanced Industrial Science and Technology
2006-2020
Albert Einstein College of Medicine
2020
University of Hyogo
2007-2017
Kobe University
1988-2015
Mukogawa Women's University
2015
Biomedical Research Institute
2012
Itami City Hospital
2004-2011
Chibune General Hospital
2009-2010
Yodogawa Christian Hospital
1998-2008
Fibroblast growth factor (FGF) 21, a structural relative of FGF23 that regulates phosphate homeostasis, is regulator insulin-independent glucose transport in adipocytes and plays role the regulation body weight. It also ketogenesis adaptive responses to starvation. We report reconstituted receptor activation assay system using BaF3 cells, which do not endogenously express any type FGF (FGFR) or heparan sulfate proteoglycan, FGF21 alone does activate FGFRs betaKlotho required for two specific...
The clonal composition of EBV-infected cells was examined in three cases EBV-associated hemophagocytic syndrome by analysis the heterogeneity terminal repetitive sequences EBV genome, indicating monoclonal expansion all cases. Involvement T lymphoid determined situ hybridization using 35S-labeled RNA probes specific for small EBV-encoded nuclear RNAs, EBER1 and EBER2, combination with immunostaining TCR-beta chain, CD45RO, CD20, CD30 CD68 antigens these majority showing EBER transcripts were...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMacrocyclic ligands composed of tetrahydrofuran for selective transport monovalent cations through liquid membranesYoshiaki Kobuke, Katsumi Hanji, Koichi Horiguchi, Masahiro Asada, Yoshinori Nakayama, and Junji FurukawaCite this: J. Am. Chem. Soc. 1976, 98, 23, 7414–7419Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October...
The highly ordered process of wound healing involves the coordinated regulation cell proliferation and migration tissue remodeling, predominantly by polypeptide growth factors. Consequently, slowing that occurs in aged may be related to changes activity these various regulatory To gain additional insight into issues, we quantified absolute copy numbers mRNAs encoding all fibroblast factors (FGFs), their receptors (FGFRs) two other dorsal skin young mice during full-thickness excisional...
A 61-year-old man had osteosclerotic myeloma that was localized in the eleventh thoracic vertebral body and associated with sensorimotor polyneuropathy, skin hyperpigmentation, edema, hypertrichosis, gynecomastia, white nails. Cases of without polyneuropathy literature were reviewed special reference to accompanying dermatologic endocrinologic signs symptoms. We assume cutaneous nails are causally related each other a remote effect myeloma. Quantitative histologic analysis two sural nerves...
By a tblastn search with β1,4-galactosyltransferases as query sequences, we found an expressed sequence tag that showed similarity in β1,4-glycosyltransferase motifs. The full-length complementary DNA was obtained by method of 5′-rapid amplification ends. predicted open reading frame encodes typical type II membrane protein comprising 543 amino acids, the which highly homologous to chondroitin sulfate <i>N</i>-acetylgalactosaminyltransferase (CSGalNAcT-1), and designated this novel enzyme...
The extracellular effect of fibroblast growth factor-12 (FGF12) remains unknown because FGF12 cannot activate any factor receptors (FGFRs), and is not currently thought to be released from cells. We reported previously that plays an intracellular role in the inhibition radiation-induced apoptosis. In this study, we demonstrated recombinant was able internalized into cytoplasm a rat intestinal epithelial cell line, IEC6, process dependent on two novel cell-penetrating peptide (CPP) domains...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural study of the sugar chains human leukocyte cell adhesion molecules CD11/CD18Masahiro Asada, Kiyoshi Furukawa, Carmela Kantor, Carl G. Gahmberg, and Akira KobataCite this: Biochemistry 1991, 30, 6, 1561–1571Publication Date (Print):February 12, 1991Publication History Published online1 May 2002Published inissue 12 February 1991https://pubs.acs.org/doi/10.1021/bi00220a017https://doi.org/10.1021/bi00220a017research-articleACS...
The effects of various types alginic acid consisting l-guluronic acids (G) and d-mannuronic (M) on hyaluronidase mast cell degranulation were examined. Alginic with an M/G ratio 1.0 exhibited the strongest inhibition both activities, higher molecular weight 150 to 370 kDa being preferable in cases. Esterification carboxyl residue enhanced latter activity.
The authors have devised a "trapping-evacuation" technique to facilitate direct clipping of giant aneurysms in the paraophthalmic region internal carotid artery (ICA). aneurysm is collapsed by first trapping temporary occlusion cervical common and external arteries, along with intracranial ICA distal aneurysm. Thereafter, intra-aneurysmal blood simultaneously aspirated through catheter placed ICA. Exposure proximal end neck mandatory for successful clipping. This accomplished extensive...
In this study, microwave irradiation was applied to hanging droplets of both water and ethylene glycol. Once the had ceased droplet allowed return its original temperature, it found that surface tension glycol returned value. contrast, remained well below value for an extended period time. Similar observations have been reported magnetically treated water, but is first time such a lasting effect has irradiation. The can be attributed unique hydrogen bonds interfacial molecules. While...
Persistent and stable expression of foreign genes has been achieved in mammalian cells by integrating the into host chromosomes. However, this approach several shortcomings practical applications. For example, large scale production protein pharmaceutics frequently requires laborious amplification inserted to optimize gene expression. The random chromosomal insertion exogenous DNA also results occasionally malignant transformation normal tissue cells, raising safety concerns medical Here we...
The plasma concentration of the platelet-specific protein beta-thromboglobulin (beta-TG) was measured in 39 normal subjects and 568 patients neurological diseases. beta-TG RIA commercially available KIT also evaluated. Abnormally high levels were demonstrated groups ischemic or obstructive cerebrovascular diseases as compared with that subjects. highest concentrations found 8 Moya-Moya disease, (mean 204.4 ng/ml), completed stroke at an acute stage next level 194.8 +/- 70.8 ng/ml). On other...