A5014249597- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Orthopaedic implants and arthroplasty
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Lepidoptera: Biology and Taxonomy
- Species Distribution and Climate Change
- Plant and animal studies
- Electrospun Nanofibers in Biomedical Applications
- Engineering Technology and Methodologies
- Additive Manufacturing and 3D Printing Technologies
- Hydraulic and Pneumatic Systems
- Cardiac Structural Anomalies and Repair
- Dental materials and restorations
- Parathyroid Disorders and Treatments
- Streptococcal Infections and Treatments
- Cardiomyopathy and Myosin Studies
- Aortic Thrombus and Embolism
- Advanced Electron Microscopy Techniques and Applications
- Aortic aneurysm repair treatments
- Bone health and treatments
- Graphene and Nanomaterials Applications
- Infectious Aortic and Vascular Conditions
- Advanced materials and composites
- Mechanical Failure Analysis and Simulation
Kemerovo State University
2018-2025
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences
2024
Kemerovo Cardiology Center
2017-2023
Institute of Systematics and Ecology of Animals
2015
Atherosclerosis, calcific aortic valve disease (CAVD), and bioprosthetic heart degeneration (alternatively termed structural deterioration, SVD) represent three diseases affecting distinct components of the circulatory system their substitutes, yet sharing multiple risk factors commonly leading to extraskeletal calcification. Whereas histopathology mentioned disorders is well-described, ultrastructural pathology largely obscure due lack appropriate investigation techniques. Employing an...
Background: Infective endocarditis (IE) is an infectious disease caused by the hematogenous dissemination of bacteria into heart valves. Improving identification pathogens that cause IE important to increase effectiveness its therapy and reduce mortality this pathology. Methods: Ten native valves obtained from patients undergoing valve replacements were analyzed. Bacterial invasion in was studied Gram staining histological sections. Histopathological changes accompanied with bacterial...
An association between high serum calcium/phosphate and cardiovascular events or death is well-established. However, a mechanistic explanation of this correlation lacking. Here, we examined the role calciprotein particles (CPPs), nanoscale bodies forming in human blood upon its supersaturation with calcium phosphate, disease. The patients coronary artery disease cerebrovascular displayed an increased propensity to form CPPs combination elevated ionised as well reduced albumin levels,...
Currently, an ultrastructural analysis of cardiovascular tissues is significantly complicated. Routine histopathological examinations and immunohistochemical staining suffer from a relatively low resolution light microscopy, whereas the fluorescence imaging plaques bioprosthetic heart valves yields considerable background noise convoluted extracellular matrix that often results in signal-to-noise ratio. Besides, sectioning calcified or stent-expanded blood vessels mineralised leads to...
Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde-treated bioprosthetic heart valves (BHVs) are well studied, those responsible failure BHVs fixed with alternative next-generation chemicals remain largely unknown. This study aimed to investigate reasons behind development SVD in ethylene glycol diglycidyl ether-treated BHVs. Methods and Results Ten excised because SVD, 5 calcified aortic (AVs) replaced calcific AV disease were collected their...
Background. Around half of bioprosthetic heart valves become dysfunctional 15 years postimplantation because structural valve deterioration notable for the degradation and calcification prosthetic tissue. Protection from requires innovative materials, science approaches including enveloping into polymer sheath. Aim. To develop a polyvinyl alcohol sheath improving resistance to calcification. Material methods. Bovine pericardium fixed with ethylene glycol diglycidyl ether was incubated...
The physical-mechanical characteristics of materials-components bioprostheses heart valves presented in clinical practice Russia, with subsequent adaptation properties for numerical modeling tasks, have been obtained and generalized. It is shown that all the studied materials a pronounced nonlinearity can be represented only form polynomial models. Comparison results computer based on coefficients showed no differences data full-scale bench tests, which made possible to verify
Hitherto, calcified aortic valves (AVs) and failing bioprosthetic heart (BHVs) have been investigated by similar approaches, mostly limited to various immunostaining techniques. Having employed multiple combinations, we demonstrated that AVs retain a well-defined cellular hierarchy even at severe stenosis, whilst BHVs were notable for the stochastic degradation of extracellular matrix (ECM) aggressive infiltration ECM-digesting macrophages. Leukocytes (CD45+) comprised ≤10% cells in but...
Aim. To study the expression patterns of matrix metalloproteinases (MMPs) -1, -2, -9, -12 in leaflets epoxy-treated bioprostheses explanted due to dysfunction and identify pathways for accumulation these enzymes xenogenic tissues. Methods. 19 from seven (Kemcor (n = 2), PeriCor UniLine 2) TiAra 1)) mitral or aortic positions during repeat heart valve replacements were included a study. Sections microscopic studies cut on standard rotary microtome. Cell typing MMP-1, evaluated using...
A 72-year-old female patient with mixed rheumatic mitral valve disease and persistent atrial fibrillation underwent replacement suffered from a combined thrombosis of the bioprosthetic left atrium as soon 2 days post operation. The immediately repeated thrombectomy. Yet, four later died due to recurrent prosthetic which both resulted in an extremely low cardiac output. In this patient's case, was notable for resistance anticoagulant therapy well aggressive neutrophil infiltration release...
Background . Using numerical modeling to study biomechanics of implantable devices for cardiovascular healthcare can help specialists understand underlying mechanisms clinical complications caused by these devices. Aim: To describe the results aneurysm formation in vascular grafts based on simulation degradation their mechanical properties. Material and Methods The was carried out using a three-dimensional computer model obtained high-resolution computed tomography graft “KemAngioProtez”...
is to assess protective capabilities of the polymer coating made polyvinyl alcohol prevent leukocyte adhesion epoxy-treated bovine pericardium, which used in production bioprosthetic heart valves.
Background . Detailed study of the histopathological events and mechanisms accompanying infectious process in native heart valves their biological prostheses is very important due to variability clinical manifestation infective endocarditis (IE). Aim : To cellular infiltration aortic (AVs) bioprosthetic (BPs) affected by infection, as well search for common patterns or differences BPs characterized degenerative changes leaflet apparatus. Material Methods We studied leaflets AVs IE (n = 10)...
Background . The average lifespan of a bioprosthetic heart valves (BHVs) is limited to 10–15 years due structural valve degeneration (SVD). One the causes SVD infiltration immune cells. Inflammation like this usually develops several after replacement, cause it remains unknown. Presumably, main stimulus response an asymptomatic colonization by bacterial agents. Aim : To study invasion BHVs explanted SVD, and identify patterns in microorganism cellular infiltrate localization. Material...
Percutaneous coronary intervention, a common treatment for atherosclerotic artery lesions, occasionally results in perforations associated with increased mortality rates. Stents coated bioresorbable polymer membrane may offer an effective solution sealing perforations. Additionally, such coatings could be mitigating neointimal hyperplasia within the vascular lumen and correcting symptomatic aneurysms. This study examines membranes fabricated by electrospinning of polycaprolactone,...
Aim: To perform a quantitative analysis of the effectiveness three concepts heart valve prosthesis support frames from perspective their safety under most critical loads, conducted through numerical modeling. Materials and Methods. The study utilized computer-generated stent-like frames, created based on similar balloon-expandable prostheses. modeling was using Abaqus/CAE software included two key loads characteristic for this element: compression implantation phases. A linear description...
Highlights Micro-computed tomography allows specialists to qualitatively and quantitatively assess the structure of calcified areas explanted bioprosthetic heart valves. This method enables evaluation changes in bioprosthesis that have occurred during its prolonged operation. Aim study . To evaluate potential high-resolution for mitral valve bioprostheses different designs due dysfunction various calcification patterns (microcalcification macrocalcification). Methods Single samples «UniLine»...