A5030998423- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Orthopaedic implants and arthroplasty
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Cardiac pacing and defibrillation studies
- Sphingolipid Metabolism and Signaling
- Cardiac, Anesthesia and Surgical Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Infectious Aortic and Vascular Conditions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Orthopedic Infections and Treatments
- Lipid metabolism and biosynthesis
- Coronary Interventions and Diagnostics
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Advanced Electron Microscopy Techniques and Applications
- Surgical Sutures and Adhesives
- Hemostasis and retained surgical items
- Molecular Biology Techniques and Applications
- Hip disorders and treatments
- Intramuscular injections and effects
Kemerovo State University
2016-2025
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences
2020-2023
Highlights Acquired valvular heart disease (AVHD) is a widespread pathology that remains one of the leading causes cardiac mortality and disability in population. The article presents an analysis changes “portrait” patients undergoing surgical treatment AVHD. Aim. To assess from baseline characteristics with acquired mitral valve before implantation bioprosthetic valve. Methods . study included 600 admitted 2000–2020 AVHD using bioprosthesis produced domestically at Research Institute for...
Here, we examined the expression of ceramide metabolism enzymes in subcutaneous adipose tissue (SAT), epicardial (EAT) and perivascular (PVAT) 30 patients with coronary artery disease (CAD) valvular heart (VHD) by means quantitative polymerase chain reaction fluorescent Western blotting. The EAT CAD showed higher genes responsible for biosynthesis (SPTLC1, SPTLC2, CERS1, 5, 6, DEGS1, SMPD1) utilization (ASAH1, SGMS1). PVAT was characterized mRNA levels CERS3, CERS4, SMPD1, enzyme (SGMS2). In...
Currently, an ultrastructural analysis of cardiovascular tissues is significantly complicated. Routine histopathological examinations and immunohistochemical staining suffer from a relatively low resolution light microscopy, whereas the fluorescence imaging plaques bioprosthetic heart valves yields considerable background noise convoluted extracellular matrix that often results in signal-to-noise ratio. Besides, sectioning calcified or stent-expanded blood vessels mineralised leads to...
Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde-treated bioprosthetic heart valves (BHVs) are well studied, those responsible failure BHVs fixed with alternative next-generation chemicals remain largely unknown. This study aimed to investigate reasons behind development SVD in ethylene glycol diglycidyl ether-treated BHVs. Methods and Results Ten excised because SVD, 5 calcified aortic (AVs) replaced calcific AV disease were collected their...
The problem of prosthetic heart valve selection in fertile women with acquired defects remains crucial modern cardiology. Mechanical valves require lifelong indirect anticoagulant therapy, which has significant fetal toxicity and is unacceptable for planning pregnancy. Bioprosthetic are the best choice women; however, their durability limited, reoperations required. We describe clinical case a 21-year-old Russian woman infectious endocarditis who underwent replacement an epoxy-treated mitral...
Highlights The article describes the first conducted pseudorandomized comparative study of mitral valve replacement using either traditional or “valve-in-valve” techniques. Abstract Aim. To compare short-term (perioperative) and medium-term (6 months) outcomes surgical treatment bioprosthetic dysfunction methods. Methods. included 18 patients undergoing (open replacement) chosen according to following criteria: heart disease type, predominant type defect, age, gender, severity presence...
<p><strong>Background</strong>. Patients with bioprosthetic valve dysfunction have a higher risk for redo procedures because of advanced age, comorbidities and redo-related technical difficulties. Thus, valve-in-valve replacement seems to be an easier safer option this group patients.<br />Objective. To assess the immediate results mitral implantation dysfunction.<br /><strong>Methods</strong>. 6 patients underwent using “UniLine” prostheses at...
A 72-year-old female patient with mixed rheumatic mitral valve disease and persistent atrial fibrillation underwent replacement suffered from a combined thrombosis of the bioprosthetic left atrium as soon 2 days post operation. The immediately repeated thrombectomy. Yet, four later died due to recurrent prosthetic which both resulted in an extremely low cardiac output. In this patient's case, was notable for resistance anticoagulant therapy well aggressive neutrophil infiltration release...
Assessment of the blood lipid spectrum does not always properly reflect local dysfunctional changes in adipose tissue and prevents identification all patients at high risk cardiovascular diseases (CVD). Monitoring sphingomyelin levels allows to assess anticipate development and/or severity these diseases, as well make sphingomyelins new therapeutic targets.
Highlights As evidenced in literature, mitral valve (MV) repair for regurgitation has many advantages, however, elderly patients have an extremely low risk of tissue degeneration, thus making the use this type surgery patient population controversial. Aim . To analyze role bioprostheses older age group undergoing replacement and compare results to outcomes. Methods The study included (over 65 years old) with who underwent annuloplasty using biological ring NeoRing (Neokor CJSC, Kemerovo) or...
Aim . To evaluate the expression of leptin receptor isoforms in local fat depots patients with coronary artery disease (CAD) and acquired heart defects (AHDs). Material methods The study included 120 CAD. comparison group consisted 96 degenerative aortic stenosis (AS). Expression six ( LEPR1 , LEPR2 LEPR2/2 LEPR3 LEPR3/2 LEPR4 ) was assessed using quantitative real-time polymerase chain reaction subcutaneous (SAT), epicardial (EAT) perivascular (PVAT) adipose tissue. Statistical processing...
Highlights Formation of adhesions after chest surgery remains an unresolved issue. The use biodegradable anti-adhesion membranes with anti-inflammatory activity can reduce the risk adhesion. Preclinical assessment developed in a large laboratory animal model is mandatory step development medical device. Aim. To conduct preclinical evaluation effectiveness anti-adhesive membrane (sheep). Methods . A composition polymers was used to manufacture membranes: polylactide-co-glycolide copolymer...
The aim of the study was to perform a series in vitro tests prototype developing heart valve prosthesis evaluate its functional characteristics. Materials and methods. In this work we have used frames full prototypes prosthesis, consisting stent-like stainless steel support frame with mounted biological leaflets cover. authors evaluated calculated experimental forces necessary for displacement sutureless implanted using test machine under uniaxial tension. risk defects damages supporting...
Aim : to evaluate the manipulative properties of system being developed for cardiac valve re-operation on an in vitro bovine heart model. Material and methods. The prototype prosthesis developed, mounted implant holder, as well dilatation balloon its own design, were used objects study. bioprosthesis «UniLine» 21 mm size aortic position was chosen target site implantation, which established by «classical» suture method. After that, implantation tested device carried out a «valve valve»...
Highlights. In the present study, we conducted a retrospective analysis redo mitral valve replacement due to prosthesis failure. Predictors of adverse events and death have been analyzed. The quality obtained predictors was verified using ROC analysis. Aim. To analyze in procedure for treating bioprostheses Methods. registry study catamnesis patients undergoing treatment dysfunction carried out. age gender patients, medical history, underlying comorbid diseases, features primary reoperation,...
Highlights . It is the first pseudorandomized comparative study of xenopericardial frame and half-frame bioprostheses treated with diepoxin in aortic position use its direct results. Aim A assessment using Propensity Score Matching method in-hospital clinical hemodynamic results semi-framed epoxy-treated prosthesis “T-ara” framed “UniLine” (“NeoKor”, Kemerovo, Russia) for isolated valve replacement implantation. Methods 33 recipients were selected by a ratio 1:1 to observations from group...
Aim. The aim of this review was to analyze publications describing studies focusing on the pathophysiological mechanisms calcification bioprosthetic heart valves, and substantiate new promising methods prevention for implantable medical devices. Material . Databases electronic libraries such as PubMed, Google Scholar eLibrary were used searching relevant articles. Search queries included following word combinations: “bioprosthetic valves”, “structural valve degeneration”, “calcification”,...
Aim. The aim of this study is to compare hospital and long-term outcomes in patients with low surgical risk after aortic stenosis correction valve replacement (SAVR) transcatheter implantation (TAVI). Materials methods . Patients (AS) were included the study. main criterion for inclusion - presence indications an isolated defect. first group TAVI (n = 11). As a control group, who underwent 23). used non-repositories CoreValve (Medtronic) repositioned Lotus (Boston Scientific) valves....
Aim. To study calcium-phosphor homeostasis and proinflammatory status of the cardiac valves bioprostheses (BP) recipients related to their interference with calcium degeneration biomaterials. Material methods. A retrospective assessment was performed metabolism markers non-specific inflammatory response in BP mitral position: histologically confirmed calcification — group I (n=22) normal morphology prosthesis function II (n=48). Results. In patients degeneration, comparing biological...
A clinical report on surgical treatment of an elderly patient with a dysfunction the bioprosthesis in mitral position is presented. Considered are methods management and at stages preparation for surgery, anesthetic management, re-intervention early postoperative period. Using proposed techniques intensive care allowed to prevent development persistent organ failure provide satisfactory stable outcome during long-term follow-up.