A5089210087- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Biomarkers in Disease Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipose Tissue and Metabolism
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Lipoproteins and Cardiovascular Health
- Sphingolipid Metabolism and Signaling
- Acute Myocardial Infarction Research
- Healthcare Systems and Public Health
- Cardiac, Anesthesia and Surgical Outcomes
- Human Health and Disease
- Mesenchymal stem cell research
- Apelin-related biomedical research
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Dietary Effects on Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipid metabolism and disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
Kemerovo State University
2015-2024
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences
2013-2024
Russian Academy of Sciences
2008-2024
Academy of Medical Sciences
2008-2011
Determination of the impact visceral obesity and epicardial adipose tissue thickness on stimulating growth factor levels during hospitalization for myocardial infarction is potential importance predicting outcomes assessing development cardiofibrotic changes associated with maladaptive remodeling. In this study, we aimed to investigate relationships between thickness, adipokine profiles, 2/interleukin-33 signaling system infarction, cardiac fibrosis extent 1-year post-MI in patients obesity....
This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial subcutaneous adipose tissues in interconnection with visceral tissue area biochemical clinical characteristics patients coronary artery disease. We assessed 84 disease (65 men, 19 women) divided them into two groups based on presence obesity. sampled then cultured evaluated their pro-inflammatory activity. Results show that mRNA expression adiponectin cultures without obesity was lower than...
Free fatty acids (FFA), oxidized low-density lipoprotein (LDL) and its antibodies, lipid profile markers, which are formed under oxidative stress, play an important role in atherosclerotic disease. Assess the levels of these markers myocardial infarction patients depending on extent coronary artery disease (CAD).ST-elevation MI with hemodynamically significant stenoses ≥ 75% one, two, three, or more arteries were examined. The divided into three groups according to severity lesions. Patients...
Here, we examined the expression of ceramide metabolism enzymes in subcutaneous adipose tissue (SAT), epicardial (EAT) and perivascular (PVAT) 30 patients with coronary artery disease (CAD) valvular heart (VHD) by means quantitative polymerase chain reaction fluorescent Western blotting. The EAT CAD showed higher genes responsible for biosynthesis (SPTLC1, SPTLC2, CERS1, 5, 6, DEGS1, SMPD1) utilization (ASAH1, SGMS1). PVAT was characterized mRNA levels CERS3, CERS4, SMPD1, enzyme (SGMS2). In...
Background: Insulin resistance (IR) is known to be characteristic of type 2 diabetes mellitus, and regarded as an important mechanism in disease pathogenesis. One the key pathogenetic mechanisms IR progression impaired free fatty acid (FFA) metabolism. Plasminogen-activator inhibitor 1 (PAI-1) inflammation markers, ie, interleukin 6 (IL-6) C-reactive protein (CRP), also play a role. Purpose: To assess changing levels metabolic proinflammation markers IL-6, CRP PAI-1 their association with...
Patients with myocardial infarction (MI) have a high mortality. Therefore, new risk markers and predictors of an adverse outcome for MI are required. The role hyperglycemia in the development cardiovascular complications patients is still unclear.A total 529 consecutive diagnosis ST-segment elevation acute coronary syndrome within 24 h onset symptoms were included study. All underwent blood glucose measurement at admission to hospital. glycemic profile, including levels early night morning...
This study aimed to evaluate the markers of insulin resistance and adipokine status in patients with visceral obesity during hospitalization following myocardial infarction (MI) assess disturbances carbohydrate metabolism present 1 year after MI onset.94 male were recruited. The exclusion criteria as follows: age less than 50 or greater 80 years, presence type 2 diabetes mellitus (T2DM), a prior history pronounced renal failure.Obesity types defined according body mass index (BMI), waist...
Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful predicting course and development complications.We included 88 patients with MI (median age, 58 yr). Depending on hospitalization, were divided into two groups: favorable (n=58) unfavorable (n=30) outcome groups. On days 1 12 after MI, serum sST2 N-terminal pro-brain natriuretic peptide (NT-proBNP) measured by ELISA.On day 1, concentrations NT-proBNP increased 2.4- 4.5-fold, compared...
Abstract Background Insulin resistance (IR) is a risk factor for ischaemic heart disease and myocardial infarction (MI). IR often manifests in MI regarded as an independent predictor of in-hospital mortality, which can provide early stratification recurrent acute coronary events. Methods The study enrolled 200 patients (130 males 70 females aged 61.4 ± 1.12 years) diagnosed with ST elevation MI. At days 1 12 from the onset, levels lipid profiles, well serum glucose, insulin, adipokine...
Dyslipidemia is one of the primary causes cardiovascular disease. Therefore, attention has been focused on development drugs that normalize lipid levels and exert an effect markers atherothrombosis, insulin resistance (IR), inflammation. Atorvastatin a drug with not only lipid-lowering potential, but it multiple non-lipid effects. This study aimed to evaluate atorvastatin effects lipid, adipokine, IR, inflammatory statuses in patients myocardial infarction (MI) in-hospital setting. included...
Background: The most common cause of myocardial infarction (MI) is stenotic atherosclerotic lesions in subepicardial coronary arteries. Artery disease progression induces clinical signs and symptoms, among which MI the leader mortality morbidity. Recent studies have been trying to find new biochemical markers that could predict evolution complications; those markers, free fatty acids (FFA) oxidative modification low-density lipoproteins (oxidized LDL) a special place. Materials methods:...
To analyze the influence of recipient-related metabolic factors on rate structural dysfunction caused by calcification xenoaortic bioprostheses.We retrospectively analyzed clinical status, calcium-phosphorus metabolism, and nonspecific markers inflammatory response in bioprosthetic mitral valve recipients with calcific degeneration confirmed histological electron microscopic studies (group 1, n=22), those without 2, n=48).Patients bioprostheses were more likely to have a severe state...
The aim of this study was to determine the relationship between thickness epicardial adipose tissue (EAT) and perivascular (PVAT) adipokine-cytokine profile patients with coronary heart disease, which can be significant importance for predicting course cardiovascular disease (CVD). Eighty-four CVD were assessed divided into two groups based on presence visceral obesity (VO). In VO, deposits left right ventricles 1.75 1.43 times greater, respectively, than in without VO. For prevalence volume...
Abstract Background To study the genetic forms and pathophysiology of arterial hypertension by evaluating plasma renin activity in Shors, minor indigenous peoples inhabiting south Western Siberia. Methods A single-stage (the Shors) non-indigenous living villages Gornaya Shoria Kemerovo region Siberia was conducted period from 2013 to 2017. One thousand four hundred nine adults (901 Shors 508 inhabitants) were recruited using a continuous sampling plan. Arterial blood pressure measured...
Background: Dyslipidemia is a key factor determining the development of both myocardial infarction (MI) and its subsequent complications. associated with endothelial dysfunction, activation inflammation, thrombogenesis, formation insulin resistance. Statin therapy thought to be effective for primary secondary prevention complications atherosclerosis. Methods: This study examined 210 patients Segment elevated MI (ST MI) who were treated atorvastatin from first 24 hours after MI. Group 1...
On average, 19-23% of patients with acute myocardial infarction (MI) suffer from type 2 diabetes mellitus, which is newly diagnosed in a significant number patients. Both classic carbohydrate metabolism and lipid may be promising diagnostic markers for insulin resistance coronary syndrome.Two hundred (130 males 70 females aged 61.4 ±1.12 years) ST-segment elevation MI were included the study. Patients divided into two groups based on manifestations diabetes: (1) 171 without within 1 year...
Insulin resistance is known to be a common feature of type 2 diabetes mellitus and regarded as an important mechanism in the pathogenesis this disease. The key pathogenetic mechanisms insulin progression are free fatty acids metabolism impairment enhanced activity plasminogen activator inhibitor 1. Both 1 recognized risk factors for coronary heart disease.THE PATIENTS WERE DIVIDED INTO TWO GROUPS: group included 65 non-diabetic myocardial infarction patients enrolled 60 diabetic patients....
Visceral adipose tissue is an important predictor of cardiovascular diseases, which carry more risk than total fat accumulation. Epicardial fat, a special form visceral deposited around the heart, considered disease, taking into account production and release adipocytokines. Recently, number experimental clinical data proving physiological metabolic significance epicardial increasing. The thickness volume (EAT) have strong correlation with obesity, impaired fasting glucose, insulin...
Background: Cardiovascular diseases and type 2 diabetes mellitus (T2DM) may have common developmental mechanisms associated with lipid metabolism disorders. Dyslipidemia progression of atherosclerosis in people T2DM are accompanied by an increase cardiovascular mortality. This study examined the dose-dependent action atorvastatin on carbohydrate adipokine status patients within 12 months after myocardial infarction (MI). Methods: A total 156 male MI who had received 20 mg/day (78 patients)...
Cytokines play an significant role in regulating non-specific inflammatory response involved many pathological processes. The current study tested the hypothesis that myocardial infarction patients with obesity can lead to increased production of proinflammatory cytokines and unfavorable course process. recruited 232 male ST-elevated infarction. mean age was 58.7 (52.2-69.9) years. All were assigned two groups according computed tomography findings: 1 (n = 160) visceral (VO), 2 72) without...