Neuropathic pain (NP) represents a debilitating and refractory condition. However, the understanding of NP current treatment approaches available for its management are limited. Therefore, there is significant need to address dearth effective therapeutic interventions. This study aims investigate regulation transient receptor potential vanilloid 1 (TRPV1) cyclin-dependent kinase 5 (CDK5) expression levels by miR-142-5p as common upstream molecule, delve into mature process from perspective...

Abstract Background Ovarian cancer (OVCA) is prevalent in female reproductive organs. Despite recent advances, clinical outcomes remain poor, warranting fresh treatment avenues. Honokiol has an inhibitory effect on proliferation, invasion, and survival of cells vitro vivo. Therefore, this study intended to explore specific molecular mechanism by which honokiol affected OVCA progression. Methods Bioinformatics analyzed the drug that bound OTU deubiquitinase, ubiquitin aldehyde binding 2...

With its estrogenic activity, (

Statins, a class of drugs that can effectively remove cholesterol from serum, are used to regulate plasma total and reduce the risk cardiovascular diseases, but it is still unclear whether drug modulated by gut microbiota or structures shaped statins. We investigated interactions between statins human during in vitro fermentation process 16S rRNA gene sequencing, gas chromatography (GC), high-performance liquid (HPLC) analyses. The presence fluvastatin (FLU2) specifically promoted growth...

Bifidobacteria are a very important group of gut microbiota, and the presence these bacteria has many beneficial effects for host. Thus, bifidobacteria have attracted growing interest owing to their potential probiotic properties.

Antibiotic resistance is a growing threat to human health. More than anything else, multidrug-resistant gram-negative bacteria pose the biggest challenge healthcare, which predominantly due lack of effective therapeutic options. In present study, we investigated activities peptides HX-12A, HX-12B and HX-12C against MDRAB MDRKP isolates in vitro. Those three displayed high antibacterial rapid bactericidal effects isolates. Additionally, retained their activity even being pH 6.8 8.0, salt...

Bone marrow mesenchymal stem cell (BMSC)-derived exosomes are a promising therapeutic agent for human disease, but their effects on neural cells (NSCs) subject to spinal cord ischaemia-reperfusion injury (SCIRI) remain unknown. Here, we examine the impact of miR-199a-5p-enriched derived from BMSCs NSC proliferation. We establish rat model aortic cross-clamping induce SCIRI in vivo and primary oxygen-glucose deprivation/reoxygenation (OGD/R) simulate vitro. CCK8, EdU, BrdU assays performed...

Abstract Background Serous ovarian carcinoma (SOC) is a common malignant tumor in female reproductive system. Long noncoding RNA (lncRNA) LIFR‐AS1 suppressor gene colorectal cancer, but its effect and underlying mechanism SOC are still unclear. Therefore, this study focuses on unveiling the regulatory of SOC. Methods The relationship between expression prognosis patients was analyzed by TCGA database Starbase, then, tissues cells detected quantitative real‐time PCR (qRT‐PCR) situ...

A stable intestinal microflora is an essential prerequisite for human health. This study investigated the interaction between Escherichia coli exopolysaccharides (named EPS-m2) and gut microbiota (HGM) in vitro . The EPS-m2 was produced by E WM3064 when treated with ceftriaxone. monosaccharide composition analysis revealed that composed of glucuronic acid, glucose, fucose, galactose/N-acetyl glucosamine, arabinose, xylose, ribose a molar ratio approximately 77:44:29:28:2:1:1. carbohydrates,...

(S)-equol (EQ) is an isoflavone with high estrogen-like activity in the human body, and only produced by some gut bacteria vivo. It plays important role maintaining individual health, however, dearth of resources associated (S)-EQ-producing has seriously restricted production application (S)-EQ. We report here a new functional gene KEC48-07020 (K-07020) that was identified from chick bacterium (Clostridium sp. ZJ6, ZJ6). found recombinant protein K-07020 possessed similar function to...

Abstract The activation of endogenous neural stem cells (NSCs) is considered an important mechanism repair after mechanical spinal cord injury; however, whether NSC proliferation can also occur ischemia–reperfusion injury (SCIRI) remains unclear. In this study, we aimed to verify the existence SCIRI and explore underlying molecular mechanism. was observed in vivo oxygen–glucose deprivation reperfusion (OGD/R) vitro, accompanied by a decrease forkhead box protein O 3a (FOXO3a) expression....

Human intestinal microorganisms have recently become an important target of research in promoting human health and preventing diseases. Consequently, investigations interactions between endobiotics (e.g., drugs prebiotics) gut microbiota topic. However, vivo experiments with volunteers are not ideal for such studies due to bioethics economic constraints. As a result, animal models been used evaluate these vivo. Nevertheless, model still limited by considerations, addition differing...

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Abstract Background Ovarian cancer (OVCA) stands as one of the most fatal gynecological malignancies. Honokiol (HNK) has been substantiated by numerous studies for its anti‐tumor activity against malignancies including OVCA. Consequently, this work was designed to elucidate impact HNK‐mediated modulation YAP/TAZ pathway on biological functions OVCA cells. Methods cells were subjected treatment with varying concentrations (0, 25, 50, 75, and 100 μM) HNK, concomitant administration YAP agonist...

This paper analyses the concept of resilience, and summarizes regional differences recovery performances innovations when coping with crisis. Taking flood as an example, constructing conceptual model resilience analytic hierarchy process (AHP) method, we get five most important indicators in a crisis: government’s credibility, crisis experience, medical health level, population density informal organization. Thereby this provides information support for government decision-making before after

The surface exopolysaccharide of Bifidobacterium spp. was found to be involved in many processes, including bacterial colonization and host immune modulation. Here, we report the draft genome sequence an exopolysaccharide-producing strain longum, BB-79.

Abstract (S) -equol is an isoflavone with high estrogen-like activity and no toxic effects in the human body, only produced by some gut bacteria vivo . It plays important role maintaining individual health, however, dearth of resources associated -equol-producing has seriously restricted production application -equol. We report here a novel functional gene C1-07020 that was identified from chick bacterium (Clostridium C1). found recombinant protein possessed similar function to daidzein...