A5003936132- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Protein Kinase Regulation and GTPase Signaling
- Botulinum Toxin and Related Neurological Disorders
- Nuclear Receptors and Signaling
- Ocular Surface and Contact Lens
- Neurological diseases and metabolism
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Marine animal studies overview
- Advanced Glycation End Products research
- Animal Vocal Communication and Behavior
- Cellular transport and secretion
- Nerve injury and regeneration
- CRISPR and Genetic Engineering
- Infant Health and Development
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Autophagy in Disease and Therapy
- Neurological disorders and treatments
- Glaucoma and retinal disorders
Universitätsmedizin Göttingen
2018-2022
University of Göttingen
2018-2021
Deutsche Forschungsgemeinschaft
2019
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2017-2018
University of Veterinary Medicine Hannover, Foundation
2012
The homeostasis of iron is fundamental importance in the central nervous system (CNS) to ensure biological processes such as oxygen transport, mitochondrial respiration or myelin synthesis. Dyshomeostasis and accumulation can be observed during aging both are shared characteristics several neurodegenerative diseases. Iron-mediated generation reactive species (ROS) may lead protein aggregation cellular toxicity. process misfolding neuronal proteins α-synuclein, Tau, amyloid beta (Aβ), TDP-43...
Human speech does not only communicate linguistic information but also paralinguistic features, e.g. about the identity and arousal state of sender. Comparable morphological physiological constraints on vocal production in mammals suggest existence commonalities encoding sender-identity a sender across mammals. To explore this hypothesis to investigate whether specific acoustic parameters encode for while others arousal, we studied infants domestic cat (Felis silvestris catus). Kittens are...
Parkinson's disease (PD) is the second-most-frequent neurodegenerative disorder worldwide. One major hallmark of PD degeneration dopaminergic (DA) neurons in substantia nigra. Glial cell line-derived neurotrophic factor (GDNF) potently increases DA neuron survival models PD; however, underlying mechanisms are incompletely understood. MicroRNAs (miRNAs) small, non-coding RNAs that important for post-transcriptional regulation gene expression. Using small RNA sequencing, we show GDNF...
Abstract Axonal degeneration is a key and early pathological feature in traumatic neurodegenerative disorders of the CNS. Following focal lesion to axons, extended axonal disintegration by acute (AAD) occurs within several hours. During AAD, accumulation autophagic proteins including Unc-51 like autophagy activating kinase 1 (ULK1) has been demonstrated, but its role incompletely understood. Here, we study effect ULK1 inhibition different models lesion-induced vitro vivo. Overexpression...
Regional iron accumulation and α-synuclein (α-syn) spreading pathology within the central nervous system are common pathological findings in Parkinson's disease (PD). Whereas is known to bind α-syn, facilitating its aggregation regulating α-syn expression, it remains unclear if how also modulates spreading. To elucidate influence of on propagation pathology, we investigated after stereotactic injection preformed fibrils (PFFs) into striatum mouse brains neonatal brain enrichment. C57Bl/6J...
Abstract The Rho kinase (ROCK) signaling pathway is an attractive therapeutic target in neurodegeneration since it has been linked to the prevention of neuronal death and neurite regeneration. isoquinoline derivative fasudil a potent ROCK inhibitor, which already approved for chronic clinical treatment humans. However, effects treatments on function are still unknown. We analyzed here primary rat hippocampal cultures. Neurons were stimulated with 20 Hz field stimulation we investigated...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder whose prevalence rapidly increasing worldwide. The mechanisms of sporadic PD are not yet completely understood. Therefore, causative therapies still lacking. To obtain a more integrative view disease-mediated alterations, we investigated molecular landscape in human post-mortem midbrains. Tissue from 13 patients and 10 controls was subjected to small RNA sequencing, transcriptomics, proteomics analysis....