A5060554948- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Hormonal Regulation and Hypertension
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory Support and Mechanisms
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Venous Thromboembolism Diagnosis and Management
- Liver Disease and Transplantation
- Acute Myocardial Infarction Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Parkinson's Disease Mechanisms and Treatments
German Centre for Cardiovascular Research
2021-2025
University Medical Center Hamburg-Eppendorf
2023-2024
Universität Hamburg
2023-2024
University of Göttingen
2020
Universitätsmedizin Göttingen
2020
Early risk stratification is essential to guide treatment in cardiogenic shock (CS). Existing CS scores were derived selected cohorts, without accounting for the heterogeneity of CS. The aim this study was develop a universal score (the Cardiogenic Shock Score, CSS) all patients, irrespective underlying cause.Within registry 1308 unselected patients admitted tertiary care hospital between 2009 and 2019, Cox regression model fitted derive CSS, with 30-day mortality as main outcome. CSS's...
Despite its high incidence and mortality risk, there is no evidence-based treatment for non-ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use mechanical circulatory support (MCS) CS treatment.In multicentre, international, retrospective study, data from 890 patients with CS, defined as due severe de-novo or acute-on-chronic heart failure need urgent revascularization, treated without active MCS, were collected. association between MCS primary endpoint 30-day...
This study aimed to investigate incidence and predictors of weaning failure in-hospital death after successful from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS). Overall, 685 CS treated VA-ECMO 23 tertiary care centres 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.6 4.1-12.7] mmol/L). The cause was acute myocardial infarction 438 (63.9%) patients, 431 (62.9%) presented...
Mechanical circulatory support devices (MCS) are potentially effective treatments for cardiogenic shock (CS) and thus evaluated in several randomised controlled trials (RCTs). However, it is not clear how enrolment criteria of these RCTs apply to a real-world CS population. This study aimed shed light on eligibility trials.Pragmatic the IABP-SHOCK II, DanGer-SHOCK, ECLS-SHOCK EURO-SHOCK were retrospectively applied 1305 patients admitted tertiary care hospital between 2009 2019. Based this,...
Abstract Axonal degeneration is a key and early pathological feature in traumatic neurodegenerative disorders of the CNS. Following focal lesion to axons, extended axonal disintegration by acute (AAD) occurs within several hours. During AAD, accumulation autophagic proteins including Unc-51 like autophagy activating kinase 1 (ULK1) has been demonstrated, but its role incompletely understood. Here, we study effect ULK1 inhibition different models lesion-induced vitro vivo. Overexpression...
Aims Heart failure‐related cardiogenic shock (HF‐CS) accounts for a significant proportion of CS cases. Whether patients with de novo HF and those acute‐on‐chronic in differ clinical characteristics outcome remains unclear. The aim this study was to evaluate differences presentation mortality between HF‐CS. Methods results In international observational study, HF‐CS from 16 tertiary care centres five countries were enrolled 2010 2021. To investigate 30‐day mortality, adjusted logistic/Cox...
Abstract Background Heart failure–related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is lack evidence on sex-related differences in HF-CS, especially regarding use treatment and mortality risk women vs. men. This study aimed to investigate potential clinical presentation, treatments, between men with HF-CS. Methods In this international observational study, patients HF-CS (without acute myocardial infarction) from 16 tertiary-care...
Acute heart failure (AHF) can result in worsening of (WHF), cardiogenic shock (CS), or death. Risk factors for these adverse outcomes are not well characterized. This study aimed to identify predictors WHF new-onset CS patients hospitalized AHF.
Veno-arterial extracorporeal membrane oxygenation therapy (VA-ECMO) restores circulation and tissue in cardiogenic shock (CS) patients, but can also lead to complications. This study aimed quantify VA-ECMO complications analyse their association with overall survival as well favourable neurological outcome (cerebral performance categories 1 + 2). All-comer patients CS treated were retrospectively enrolled from 16 centres four countries (2005-2019). Neurological, bleeding, ischaemic adverse...
Shock of any cause leads to end-organ damage due ischaemia, especially in perfusion-sensitive organs such as the liver. In septic shock, hypoxic hepatitis (S-HH) is defined 20-fold increase upper normal limit aspartate aminotransferase (ASAT) and alanine (ALAT) associated with a mortality up 60%. However, pathophysiology, dynamics, treatment differ between cardiogenic shock (CS), S-HH definition may not be suitable for CS. Therefore, we aim evaluate if applicable CS patients. This analysis...
Abstract Background Currently, use of mechanical circulatory support (MCS) in non-ischaemic cardiogenic shock (CS) is predominantly guided by shock-specific markers, and not markers cardiac function. We hypothesise that left ventricular ejection fraction (LVEF) can identify patients with a higher likelihood to benefit from MCS thus help optimise their expected benefit. Methods Patients CS available data on LVEF 16 tertiary-care centres five countries were analysed. Cox regression models...
Abstract Background Mortality in cardiogenic shock (CS) remains high even when mechanical circulatory support (MCS) restores adequate circulation. To detect a potential contribution of systemic inflammation to severity, this study determined associations between C-reactive protein (CRP) concentrations and outcomes patients with CS. Methods Unselected, consecutive CS CRP measurements treated at single large cardiovascular center 2009 2019 were analyzed. Adjusted regression models fitted...
Abstract Aims The optimal timing for implementing mechanical circulatory support (MCS) in cardiogenic shock (CS) remains indeterminate. This study aims to evaluate patient characteristics and outcome associated with the time interval between CS onset veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) implementation. Methods results In this study, patients treated MCS at 15 tertiary care centres three countries were enrolled. Patients stratified into early (<2 h), intermediate...
Congestion is a major determinant of outcomes in acute heart failure. Its assessment complex, making sufficient decongestive therapy challenge. Residual congestion frequent at discharge, increasing the risk re-hospitalization and death. Mid-regional pro-adrenomedullin mirrors vascular integrity may therefore be an objective marker to quantify guide therapies patients with
Abstract Background Evidence supporting pre-hospital heparin administration in patients with suspected non-ST segment elevation acute coronary syndrome (NSTE-ACS) is lacking. We aim to evaluate if by emergency medical service improves clinical outcome NSTE-ACS. Methods Patients myocardial infarction (MI) presenting the department were prospectively enrolled from 2013 2021, excluding those ST MI. and without prehospital compared using propensity score matching. To assess association between...