Gavino Napolitano

ORCID: 0000-0001-6256-6235
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About
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Research Areas
  • Clinical Laboratory Practices and Quality Control
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • COVID-19 diagnosis using AI
  • Reliability and Agreement in Measurement
  • Meta-analysis and systematic reviews
  • Vaccine Coverage and Hesitancy
  • Blood properties and coagulation
  • Mycobacterium research and diagnosis
  • Data-Driven Disease Surveillance
  • Intravenous Infusion Technology and Safety
  • Tuberculosis Research and Epidemiology
  • Diagnosis and treatment of tuberculosis
  • Animal Virus Infections Studies
  • Monoclonal and Polyclonal Antibodies Research
  • Health and Medical Research Impacts
  • Digital Imaging for Blood Diseases

Ospedale Papa Giovanni XXIII
2016-2024

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic calls for rapid actions, now principally oriented to a world‐wide vaccination campaign. In this study we verified if, in individuals with previous SARS‐CoV‐2 infection, single dose of messenger RNA (mRNA) vaccine would be immunologically equivalent full schedule naïve individuals. Health care workers (184) infection were sampled soon before the second and between 7 10 days after dose, last sampling time was...

10.1002/jmv.26982 article EN Journal of Medical Virology 2021-03-31

Different hematological analyzers have different analytical performances that are often reflected in the criteria for sample stability of complete blood count. This study aimed to assess several parameters using XN-9000 Sysmex and BC-6800 Mindray analyzers.The impact storage at room temperature 4°C was evaluated after 2, 4, 6, 8, 24, 36 48h ten normal 40 abnormal samples. The variation from baseline measurement by Steel-Dwass-Critchlow-Fligner test Bland-Altman plots, quality specifications...

10.1016/j.bjhh.2016.05.010 article EN cc-by-nc-nd Revista Brasileira de Hematologia e Hemoterapia 2016-06-23

Abstract Introduction In the hub and spoke laboratory network, number of hematology analyzers (HAs) within each core center has increased, control HAs alignment is becoming necessary requirement to ensure analytical quality. this scenario, HA can be assessed by analyzing same material used for internal quality on multiple HAs, assuming its commutability. The aim study was verify applicability a protocol based rather than fresh whole‐blood samples. Methods five evaluated red (RBC, Hb, MCV,...

10.1111/ijlh.13379 article EN International Journal of Laboratory Hematology 2020-11-10

Abstract Background The SARS-CoV-2 pandemic calls for rapid actions, now principally oriented to a world-wide vaccination campaign. In this study we verified if, in individuals with previous infection, single dose of mRNA vaccine would be immunologically equivalent full schedule naïve individuals. Methods Health care workers (184) infection were sampled soon before the second and between 7 10 days after dose, last sampling time was applied individuals, too. Antibodies against measured using...

10.1101/2021.03.09.21253203 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-03-11

We report the isolation of two human IgG1k monoclonal antibodies (mAbs) directed against SARS-CoV-2 spike protein. These mAbs were isolated from donors who had recovered COVID-19 infection during first pandemic peak in Lombardy region Italy, European and initially most affected March 2020. used method EBV immortalization purified memory B cells supernatant screening with a S1/2 assay for mAb isolation. This allowed rapid clones, one donor showing about 7% clones positive protein, whereas...

10.3390/antib10030026 article EN cc-by Antibodies 2021-07-05

INTRODUCTION. The transport and storage of biological material represent critical phases the entire analytical process, which must ensure stability samples to be analyzed in laboratory. AIM The aim this paper is describe state art relation problems samples. In particular, handling, packaging procedures will described order protect health safety staff involved these operations not modify diagnostic properties samples. MATERIALS AND METHODS The chain begins with ends delivery recipient....

10.30459/2020-31 article EN 2019-06-24

On January 12, 2020, the World Health Organization (WHO) declared Covid-19 an emergency of international interest. The first documented case in "Pope John XXIII" Hospital Bergamo was identified on Friday, February 21, 2020. ASST Pope XXIII among very Companies to implement a series organizational remodelling quickly face health from Sars-Cov-2 outbreak. In this context, we will describe role and changes adopted by Complex Operating Unit (UOC) Microbiology Virology. Laboratory diagnostics can...

10.36017/jahc2102-004 article EN Journal of Advanced Health Care 2021-02-26

Abstract Introduction Point of care testing (POCT) represents a valuable option when laboratory data shall be urgently available for timely clinical management, with turnaround time (TAT) that is unfeasible using conventional instrumentation. This study was aimed to compare the performance QBC STAR™ compared Sysmex XN‐module and reference optical microscopy (OM) assessment. Material Methods One hundred peripheral blood samples, collected in K 3 EDTA tubes, 50 capillary samples obtained by...

10.1111/ijlh.13515 article EN International Journal of Laboratory Hematology 2021-03-22

On January 12, 2020, the World Health Organization (WHO) declared Covid-19 an emergency of internationalinterest. The first documented case in “Pope John XXIII” Hospital Bergamo was identified on Friday, February21, 2020.The ASST Pope XXIII among very Companies to implement a series oforganizational remodelling quickly face health from Sars-Cov-2 outbreak.In this context, we will describe role and organizational changes adopted by Complex Operating Unit (UOC)Microbiology Virology.Laboratory...

10.36017/jahc202133159 article EN Journal of Advanced Health Care 2021-02-26
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