A5064874945- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- ATP Synthase and ATPases Research
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- interferon and immune responses
- Epigenetics and DNA Methylation
- Energy and Environment Impacts
- Influenza Virus Research Studies
- CRISPR and Genetic Engineering
- Air Quality and Health Impacts
- Animal Genetics and Reproduction
- Peptidase Inhibition and Analysis
Instituto Nacional de Enfermedades Respiratorias
2015-2024
The University of Texas MD Anderson Cancer Center
2010-2012
Idiopathic pulmonary fibrosis is a devastating lung disorder of unknown etiology. Although its pathogenesis unclear, considerable evidence supports an important role aberrantly activated alveolar epithelial cells (AECs), which produce large variety mediators, including several matrix metalloproteases (MMPs), participate in fibroblast activation and remodeling. MMP-1 has been shown to be highly expressed AECs from idiopathic lungs although unknown. In this study, we explored the functions....
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. A conspicuous feature the formation and persistence fibroblastic/myofibroblastic foci throughout parenchyma. Mechanisms remain unknown, but data indicate that fibroblasts acquire an antiapoptotic phenotype. We hypothesized transcriptional silencing proapoptotic genes may be implicated, accordingly we evaluated epigenetic regulation p14 ARF . The expression was analyzed by RT-PCR in IPF ( n = 8) normal...
The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically/transcriptionally involved terms resistance to oncology therapy poorer clinical outcomes for patients with lung cancer. We evaluated the role using RT‐qPCR, western blot, immunofluorescence analyses, gene silencing, cellular cytotoxic,...
Lung cancer is the leading cause of death from malignant diseases worldwide, with non-small cell (NSCLC) subtype accounting for majority cases. NSCLC characterized by frequent genomic imbalances and copy number variations (CNVs), but epigenetic aberrations that are associated clinical prognosis therapeutic failure remain not completely identify. In present study, a total 55 lung patients were included we conducted genetic expression analyses, immunohistochemical protein detection, DNA...
// Leonel Armas-López 1 , Patricia Piña-Sánchez 2 Oscar Arrieta 3 Enrique Guzman de Alba 4 Blanca Ortiz-Quintero Patricio Santillán-Doherty David C. Christiani 5 Joaquín Zúñiga and Federico Ávila-Moreno 1, National University Autonomous of México (UNAM), Facultad Estudios Superiores (FES) Iztacala, Biomedicine Research Unit (UBIMED), Lung Diseases And Cancer Epigenomics Laboratory, Mexico State, Instituto Mexicano del Seguro Social (IMSS), Centro Medico Nacional (CMN) Siglo XXI, Unidad...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive aging-associated disease of unknown etiology. A growing body evidence indicates that aberrant activated alveolar epithelial cells induce the expansion activation fibroblast population, leading to destruction lung architecture. Some matrix metalloproteinases (MMPs) are upregulated in IPF, indicating they may be important pathogenesis and/or progression IPF. In present study, we examined expression MMP28 this evaluated its...
Interstitial lung abnormalities (ILA) are observed in around 9% of older respiratory asymptomatic subjects, mainly smokers. Evidence suggests that ILA may precede the development interstitial diseases and evolve to progressive fibrosis. Identifying biomarkers this subclinical status is relevant for early diagnosis predict outcome. We aimed identify circulating microRNAs (miRNAs) associated a cohort subjects than 60 years. identified 81 with from our Lung-Aging Program Mexico City (n = 826)....
Cigarette smoking is a known risk factor for the development of lung cancer. We investigated whether circulating microRNA expression levels and their potential diagnostic value are affected by cigarette in adenocarcinoma (AD) patients healthy (H) participants. In total, 71 female AD 91 H individuals were recruited, including 42 never-smokers (AD/CS−), 29 smokers (AD/CS+), 54 (H/CS−), 37 (H/CS+). PCR array (754 microRNAs) qPCR performed on sera from discovery validation cohorts, respectively....
. In passages above ten and growing very actively, we observed that some human lung fibroblasts cultured under standard conditions were transformed into a lineage of epithelial-like cells (ELC). To systematically evaluate the possible mesenchymal–epithelial transition (MET) occurrence, obtained from normal lungs also affected by idiopathic interstitial diseases. When an unusual phenotypic change was observed, characterized confocal immunofluorescence microscopy, immunoblotting,...