A5008093265- Plant-Microbe Interactions and Immunity
- GABA and Rice Research
- Rice Cultivation and Yield Improvement
- Flavonoids in Medical Research
- Plant Pathogenic Bacteria Studies
- Genetic Mapping and Diversity in Plants and Animals
- Plant Disease Resistance and Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Plant Gene Expression Analysis
- Cancer, Lipids, and Metabolism
- Hereditary Neurological Disorders
- Spinal Cord Injury Research
- Liver Disease Diagnosis and Treatment
- Plant tissue culture and regeneration
- Fungal and yeast genetics research
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Medicinal Plants and Neuroprotection
- Calcium signaling and nucleotide metabolism
- Tissue Engineering and Regenerative Medicine
- Estrogen and related hormone effects
- Hepatocellular Carcinoma Treatment and Prognosis
- PARP inhibition in cancer therapy
Sichuan University
2019-2025
West China Hospital of Sichuan University
2019-2025
Guangdong Academy of Agricultural Sciences
2015-2025
Rice Research Institute
2010-2025
Ministry of Agriculture and Rural Affairs
2023-2025
State Key Laboratory of Biotherapy
2025
First Hospital of China Medical University
2024
China Medical University
2024
Fujian Medical University
2024
First Affiliated Hospital of Nanchang University
2023
• The rice–rice blast pathosystem is of great interest, not only because the damaging potential rice to crop, but also both pathogen and its host are experimentally amenable. resistance gene Pik, which one five classical alleles located at Pik locus on long arm chromosome 11, confers high stable many Chinese isolates. isolation functional characterization were performed in present study through genetic genomic approaches. A combination Pik-1 Pik-2 required for expression resistance. Both...
Rat neonate cardiomyocytes were cultured and treated with AGEs at different concentration. Two classic autophagy markers, microtubule-associated protein 1 light chain 3 (LC3) Beclin-1, detected by western blot assay. The inhibition of RAGE phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mTOR pathway applied to cells, respectively. administration enhanced the expression Beclin-1 LC3 II in cardiomyocytes, increased number autophagic vacuoles impaired cell viability dose-dependant manners....
Glioma is the most common primary intracranial tumors. Although great achievements have been made in treatment, efficacy still unsatisfactory, which imposes a hefty burden on patients and society. Therefore, exploration of new effective anti-glioma drugs urgent. Human glioma cell lines U251 LN229 were included study. Cell proliferation was detected by counting kit-8 (CCK8), plate clone formation assay, EdU incorporation assay xCELLigence real-time analyzer. apoptosis evaluated TUNEL flow...
This study aimed to develop an aromatic thermosensitive genic male sterile (TGMS) line in indica rice using CRISPR/Cas9 technology. The TMS5 and FGR the high-quality conventional variety Huahang 48 were targeted for editing vectors designed constructed introduced into calli through Agrobacterium-mediated transformation. Transgenic seedlings subsequently regenerated, target sites of edited plants analyzed via sequencing. A total fifteen T0 double mutants successfully obtained. Three without...
ABSTRACT Aims Neuropathic pain (NP) is a debilitating condition characterized by chronic resulting from nerve damage or lesion. Despite the ongoing efforts of clinically defining NP, its distinctive mechanisms that lead to various NP phenotypes remain unresolved. Methods Using spared injury (SNI) model, we investigated underlying development caused in peripheral nerves. With CRISPR‐Cas9‐mediated knockout and virus‐mediated overexpression strategies, role LncRNA Vof16 (abbreviated as Vof16)...
Bacterial blight (BB) is an important constraint on achieving a high and stable rice grain yield. An increasing number of BB resistance (R) genes have been identified cloned to increase the available options for disease breeding. However, it necessary understand distribution R in varieties rational Here, we genotyped five against seventy main cultivars from Guangdong Province, South China, using corresponding specific markers. Our results showed that 87.1% tested carried Xa4, only three...
Abstract Leaf senescence is one of the most precisely modulated developmental process and affects various agronomic traits rice. Anti-senescence rice varieties are important for breeding application. However, little known about mechanisms underlying metabolic regulatory leaf in In this study, we performed transcriptomic metabolomic analyses flag leaves Yuenong Simiao (YN) YB, two indica cultivars that differ terms their senescence. We found 8524 genes/204 metabolites were differentially...
Abstract Rice quality is one of the main targets rice breeding and a complex trait that involves grain appearance, milling, cooking, eating nutritional quality. For many years, has contended with imbalances in yield, quality, disease lodging resistance. Here, milling appearance cooking starch rapid viscosity analyzer (RVA) profile, grains Yuenongsimiao (YNSM), an indica variety high resistance, were determined. YNSM had excellent low amylose contents gel consistency, these characteristics...
The elite rice cultivar Yuejingsimiao 2 (YJ2) is characterized by a high level of grain quality and yield, resistance against Magnaporthe oryzae. YJ2 showed 100% to four fungal populations collected from Guangdong, Sichuan, Liaoning, Heilongjiang Provinces, which higher frequency than that shown the well-known (R) gene donor cultivars such as Sanhuangzhan 28zhan. Segregation analysis for with F(2) F(4) indicated was controlled multiple genes are dominant or recessive. putative R were roughly...
Transplantation of neural stem cells (NSCs) is a potential strategy for the treatment spinal cord transection (SCT). Here we investigated whether transplanted NSCs would improve motor function rats with SCT and explored underlying mechanism. First, were divided into sham, SCT, NSC groups. Rats in groups all subjected to T10, administered media transplantation lesion site, respectively. Immunohistochemistry was used label Nestin-, TUNEL-, NeuN-positive reveal expression location type I...
Traumatic brain injury (TBI) often leads to severe neurobehavioral impairment, but the underlying molecular mechanism remains be elucidated. Here, we collected sera from 23 patients (aged 19 81 years old, third day after TBI as TBI-third group) subjected The First Hospital of Kunming City, and 22 healthy donors 18 old control group). Then, three samples group were protein microarray detection, bioinformatics analysis. enzyme-linked immunosorbent assay (ELISA) was used verify significantly...
Blast, caused by the ascomycete fungus Magnaporthe oryzae, is one of most devastating diseases rice due to high variation pathogen. Breeding high-yielding cultivar with durable resistance blast a priority in Southern China and places where cultivation an important branch farming. Effectiveness accuracy resistant breeding largely depend on development markers specific target gene. In silico prediction (R) Pi39 gene content interval was made hence candidate identified develop perfect...
Harvest index (HI) in rice is defined as the ratio of grain yield (GY) to biomass (BM). Although it has been demonstrated that HI significantly related and considered one most important traits high-yielding breeding, HI-based breeding difficult due its polygenic nature insufficient knowledge on genetic basis HI. Therefore, searching for varieties with high mapping genes associated can facilitate marker-assisted rice.Yuexiangzhan, a popular indica cultivar good reputation was crossed...
Glioma is the most common malignant brain tumor and patients are prone to poor prognosis. Due limited treatments, new drug exploration has become a general trend. Therefore, objective of this study investigate effect drugs C18H17NO6 its combination with Scutellarin on glioma cells underlying mechanism.U251 LN229 were administrated Scutellarin. The proliferation ability was determined by cell counting kit-8, plate clone formation assay, EdU incorporation assay. cycle apoptosis detection...
Glioma, the most common intracranial tumor, harbors great harm. Since treatment for it has reached bottleneck stage, development of new drugs becomes a trend. Therefore, we focus on effect scutellarin (SCU) and its combination with C 18 H 17 NO 6 (abbreviated as ) glioma possible mechanism in this study. Firstly, SCU both suppressed proliferation U251 LN229 cells dose-dependent manner, augmented inhibition vitro . Moreover, there was an interactive between them. Secondly, decreased G2 phase...
The genetic control of grain weight (GW) remains poorly understood.Quantitative trait loci (QTLs) determining the GW rice were identified using a natural mutant, sgw.Using segregating population derived from sgw (low GW) and cultivar 9311 ('9311'; indica, high GW), chromosome segment associated with was detected on short arm 7.To validate further refine locus, QTL analysis based F 2 3 populations conducted, single major (designated as qsgw7) affecting 1000-grain paddy region 7 between simple...