A5024936477- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Oral microbiology and periodontitis research
- Urinary Tract Infections Management
- Malaria Research and Control
- Vibrio bacteria research studies
- Pneumonia and Respiratory Infections
- Infection Control and Ventilation
- Dental Research and COVID-19
- Gut microbiota and health
- Hemoglobinopathies and Related Disorders
- Infection Control in Healthcare
- Reproductive tract infections research
- Streptococcal Infections and Treatments
- Probiotics and Fermented Foods
- Focus Groups and Qualitative Methods
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
Cardiff University
2023-2025
Mohammed Bin Rashid University of Medicine and Health Sciences
2016-2025
University of Medicine and Health Sciences
2024
Alfaisal University
2011-2017
King Faisal Specialist Hospital & Research Centre
2016
King Khalid University Hospital
2016
King Saud University
2016
University of Sharjah
2007-2011
Arabian Gulf University
2005-2007
University of Glasgow
2005
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity clonal complexes (CCs) identified. COVID-19 pandemic, its increased hospitalization rates and antibiotic use, may have further influenced MRSA’s genetic evolution epidemiology country. Methods: To investigate this influence, genomic profiling of 310 clinical...
To assess the prevalence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella strains in nosocomial community-acquired infections.The study was conducted at a centralized microbiology laboratory Eastern Province Saudi Arabia. Laboratory records (January 2004 - December 2005) were assessed. Associated resistance to panel antibiotics determined.A total 6,750 Gram-negative organisms assessed for ESBL-phenotype. ESBL detected 6% (409/6,750) isolates, majority...
ObjectivesTo investigate the emergence of NDM-, OXA-48-, and VIM-producing Klebsiella pneumoniae in Saudi Arabia.MethodsFrom June to December 2011, we obtained K. isolates with reduced sensitivity carbapenem identified Riyadh, Arabia. Only non-duplicate clinical surveillance from inpatients were included. PCR amplification was carried out for detection extended-spectrum beta-lactamase genes (blaCTX-M, blaTEM, blaSHV) carbapenemase (blaKPC, blaVIM, blaIMP, blaNDM, blaOXA-48). Susceptibility...
The ongoing COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Age, smoking, obesity, and chronic diseases such as cardiovascular disease diabetes have been described risk factors for severe complications mortality in COVID-19. Obesity are usually associated with dysregulated lipid synthesis clearance, which can initiate or aggravate pulmonary inflammation injury. It has shown that viral entry into host cell, SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) receptors...
Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward development a vaccine against SARS-CoV-2, such will not be available in time to contribute containment pandemic. Therefore, there is an urgent need develop framework rapid identification novel targets diagnostic and therapeutic interventions. We analyzed publicly transcriptomic datasets SARS-CoV infected humans mammals identify consistent differentially expressed...
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To investigate the prevalence and antibiotic susceptibility pattern of extended-spectrum beta-lactamases (ESBL)-producing Enterobacteriaceae among patients in United Arab Emirates.A total 130 comprising Escherichia coli (n = 83), Klebsiella pneumoniae 45) oxytoca 2) was studied. Of these isolates, 64 were from urine. ESBL screening by disc diffusion confirmatory tests for phenotype conducted using BD Phoenix System cephalosporin/clavulanate combination discs. Susceptibility to a panel...
With the easing of restriction measures, repeated community-based sampling for tracking new COVID-19 infections is anticipated next 6 to 12 months. A non-invasive, self-collected specimen like saliva will be useful such public health surveillance. Investigations on use SARS-CoV-2 RT-PCR have largely been among in-pa\tients and symptomatic ambulatory patients with limited work in a screening setting. This study was carried out address this paucity data reported discrepancies diagnostic...
ST239-MRSA-III is probably the oldest truly pandemic MRSA strain, circulating in many countries since 1970s. It still frequently isolated some parts of world although it has been replaced by other strains in, e.g., most Europe. Previous genotyping work (Harris et al., 2010; Castillo-Ramírez 2012) suggested a split geographically defined clades. In present study, collection 184 isolates, mainly from not covered previous studies were characterized using two DNA microarrays (i) targeting an...
The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 that impacts lower respiratory tract. spectrum of symptoms ranges from asymptomatic infections mild lethal form which associated with severe pneumonia, acute distress and fatality. At present, global case fatality rate laboratory confirmed cases ~4.7% ranging ~0.3-0.4% in Chile Israel ~10.8% Italy. To address this crisis, up-to-date information on viral genomics transcriptomics crucial for understanding origins...
The SEIR (Susceptible-Exposed-Infected-Removed) model is widely used in epidemiology to mathematically the spread of infectious diseases with incubation periods. However, prototype generic and not able capture unique nature a novel viral pandemic such as SARS-CoV-2. We have developed tested specialized version model, called SEAHIR (Susceptible-Exposed-Asymptomatic-Hospitalized-Isolated-Removed) model. This proposed dynamics COVID-19 outbreak including further dividing Infected compartment...
Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; high negative charge density provides with immense chelating ability valuable antioxidant properties. also simple cost-effective to produce. These features have attracted researchers entrepreneurs further study wide variety of applications areas such as pharmaceutical, food chemical...
Differentiation between Campylobacter jejuni and coli is problematic in clinical specimens due to fastidious growth requirements limited biochemical tests. This study describes a rapid, multiplex PCR protocol for the direct detection differentiation of C. stools. An evaluation was carried out this based on cadF (genus specific), hipO (C. jejuni) asp coli) genes, using stool from patients with enteritis chicken. Protocol sensitivity assessed specificity determined panel enteric bacteria, 30...
Changes in the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) continue to be reported. This study was carried out characterize MRSA isolates Saudi Arabia. causing nosocomial infections (n = 117) obtained from 2009–2015 at a tertiary-care facility Riyadh, Arabia, were studied. Molecular characterization using StaphyType DNA microarray (Alere Technologies, Jena, Germany). Fourteen clonal complexes (CC) identified, with most common being CC80 35), CC6 15), CC5 13)...
Abstract The ongoing COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Age, smoking, obesity, and chronic diseases such as cardiovascular disease diabetes have been described risk factors for severe complications mortality in COVID-19. Obesity are usually associated with dysregulated lipid synthesis clearance which can initiate or aggravate pulmonary inflammation injury. It has shown that viral entry into host cell, SARS-CoV-2 utilizes angiotensin converting enzyme 2 (ACE2)...
Microbial coinfections in COVID-19 patients carry a risk of poor outcomes. This study aimed to characterize the clinical and microbiological profiles with COVID-19.A retrospective review laboratory records laboratory-confirmed infections bacteria, fungi, viruses was conducted. Only adult hospitalized at participating health-care facilities between February 1 July 31, 2020 were included. Data collected from centralized electronic system Dubai Health Authority hospitals Sheikh Khalifa General...
Objectives Staphylococcus aureus is a leading cause of hospital acquired infections worldwide. Over recent decades, methicillin resistant (MRSA), which to multiple antimicrobials, has emerged as significant pathogenic strain in both and community settings. The rapid emergence dissemination MRSA clones are driven by dynamic evolving population, spreading swiftly across regions on epidemiological time scales. Despite the vast geographical expanse diverse demographics Kingdom Saudi Arabia...
The microbiota of endodontic infections in patients from the Arabian Gulf region (AGR) is largely unexplored. While research different global regions has investigated microbial composition such infections, studies using shotgun metagenomic sequencing (SMS) alongside culture-dependent techniques (CDT) are limited. There also few vitro biofilm models that reflect profiles infections. Therefore, by employing SMS and CDT, this aimed to explore compositional functional AGR. sought develop ex vivo...
Limited data exist from the Gulf Cooperation Council states on prevalence and population dynamics of Staphylococcus aureus colonizing livestock or contaminating retail meat. This study was designed to determine presence genetic characteristics isolated raw meat sold in Riyadh, Saudi Arabia. Over a period 9 months, different types were aseptically processed using double broth enrichment technique, characteristic colonies chromogenic mannitol salt agar further identified conventional methods....
International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions world will further inform dynamics pandemic. Using data Dubai United Arab Emirates (UAE), major international hub Middle East, we establish SARS-CoV-2 full genome sequences index and COVID-19 patients UAE. The are analysed context virus introductions, chain transmissions, possible links to earlier strains other world. Phylogenetic analysis showed...