A5030956640- Physiological and biochemical adaptations
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Classical Antiquity Studies
- Genetics and Physical Performance
- Aquaculture disease management and microbiota
- Fish Ecology and Management Studies
- Muscle Physiology and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Hemoglobin structure and function
- Congenital heart defects research
- Genetic diversity and population structure
- Hemoglobinopathies and Related Disorders
- Classical Philosophy and Thought
- RNA Research and Splicing
- Hypothalamic control of reproductive hormones
- Genetic and phenotypic traits in livestock
- Birth, Development, and Health
- Neurobiology and Insect Physiology Research
- Heat shock proteins research
- Adipose Tissue and Metabolism
- Linguistics and language evolution
- Developmental Biology and Gene Regulation
Norwegian University of Life Sciences
2016-2025
Nofima
2016-2025
University of Bergen
2024
Fafo Foundation
2012-2023
University of Oslo
1975-2018
Akvaforsk Genetics Center (Norway)
1995-2008
Norwegian Biodiversity Information Centre
2005-2006
Herlev Hospital
1994
The Research Council of Norway
1992
Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster an unusual immune architecture compared to other sequenced vertebrates. The assembly was obtained exclusively by 454 sequencing shotgun paired-end libraries, automated annotation identified 22,154 genes. major histocompatibility (MHC)...
Abstract Atlantic cod is composed of multiple migratory and stationary populations widely distributed in the North Ocean. The Northeast Arctic (NEAC) population Barents Sea undertakes annual spawning migrations to northern Norwegian coast. Although occurs sympatrically with coastal (NCC), phenotypic genetic differences between NEAC NCC are maintained. In this study, we resolve enigma by revealing mechanisms underlying these differences. Extended linkage disequilibrium (LD) divergence were...
The extreme polymorphism found at some major histocompatibility complex (MHC) loci is believed to be maintained by balancing selection caused infectious pathogens. Experimental support for this inconclusive. We have studied the interaction between certain MHC alleles and bacterium Aeromonas salmonicida, which causes severe disease furunculosis, in Atlantic salmon (Salmo salar L.). designed full–sibling broods consisting of combinations homozygote heterozygote genotypes with respect...
Two myostatin isoforms were identified in Atlantic salmon (Salmo salar) by RT-PCR, and genomic sequences encoding this negative muscle growth factor for the first time isolated from a nonmammalian species. Salmon isoform I is transcribed white skeletal as 2346-nucleotide mRNA species that encodes precursor protein of 373 amino acids. shows 93% sequence identity with II which was partial cDNA 1409 nucleotides. In contrast to restricted gene expression mammals, mRNAs RT-PCR multiple tissues,...
Apoptosis has a vital impact on the development and homeostasis of all multicellular organisms. Hence, metazoan species seem to possess necessary components apoptotic machinery, but in general, their numbers complexity have increased during evolution. The key factors are cascade cysteine proteases known as caspases. fish homologous almost mammalian caspases also been identified, several fish‐specific with putative distinct functions reported. Despite these differences, extrinsic intrinsic...
The development of ectothermic embryos is strongly affected by incubation temperature, and thermal imprinting body growth muscle phenotype has been reported in various teleost fishes. complex epigenetic regulation vertebrates involves DNA methylation the myogenin promoter. Body a heritable highly variable trait among fish populations that allows for local adaptations, but also selective breeding. Here we studied effects embryonic temperature genetic background on growth, cellularity...
Atlantic salmon (Salmo salar) might encounter toxic hydrogen sulphide (H
A 30-residue N-terminally acetylated peptide derived from the N-terminal part of histone H1 was identified as dominant antimicrobial in skin mucus Atlantic salmon (Salmo salar). The (termed [SAMP H1]) purified to homogeneity by a combination reversed-phase and cation-exchange chromatographies. By Edman degradation deacetylated sequencing PCR-amplified DNA that encodes peptide, complete amino acid sequence determined be AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS. theoretical molecular weight SAMP...
A major challenge in evolutionary biology is to identify the genes underlying adaptation. The oxygen-transporting haemoglobins directly link external conditions with metabolic needs and therefore represent a unique system for studying environmental effects on molecular evolution. We have discovered two haemoglobin polymorphisms Atlantic cod populations inhabiting varying temperature oxygen regimes North Atlantic. Three-dimensional modelling of tetrameric structure demonstrated that amino...
(1976). Some thoughts on the shield of Achilles. Symbolae Osloenses: Vol. 51, No. 1, pp. 5-18.
Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation be altered by such stimuli. To assess how stress might affect methylome transcriptome in salmon, fish were treated using cold-shock air-exposure from eye-stage until start-feeding. The either stressed prior hatching (E), post-hatching (PH), pre- (EPH) or not (CO). Assessing abundances just start feeding, E PH...
The factors of the Sox9-Amh-Cyp19a1 cascade play a crucial role in complex process sex differentiation mammals. involvement Sox9 and Cyp19a1 paralogs single Amh ortholog development gonads brain Atlantic cod was examined by analyzing bimodal sex-dimorphic gene expression patterns, respectively, during early stages maturing males females. Expression sox9a sox9b were initiated at blastulation, both expressed chondrogenic tissue hatched larvae. male-specific adult supports conserved testis...
Hydrogen sulphide (H2S) is known to regulate various physiological processes, but its role in fish cardiac function, especially at the molecular level, poorly understood. This study examined functions of exogenous H2S, using sodium hydrosulphide (NaHS) as a donor, on Atlantic salmon cardiomyocytes. NaHS concentrations 10 160 μM showed limited cytotoxicity and no impact cell proliferation, though higher doses increased ATP activity. Menadione administered separately or sequentially...
Stress during early life has potential to program and alter the response stressful events metabolism in later life. Repeated short exposure of Atlantic salmon cold water air embryonic (E), post-hatch (PH) or both phases development (EPH) been shown methylome transcriptome affect growth performance compared untreated controls (CO). The aim this study was investigate how these fish responds subsequent acute stress at start feeding stage, describe methylation differences that might steer...