A5061397066- Acute Myeloid Leukemia Research
- Zebrafish Biomedical Research Applications
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Aquaculture disease management and microbiota
- Trace Elements in Health
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- PARP inhibition in cancer therapy
- Kruppel-like factors research
- TGF-β signaling in diseases
- Extracellular vesicles in disease
- Occupational and environmental lung diseases
- Cancer Treatment and Pharmacology
- Congenital heart defects research
- Calcium signaling and nucleotide metabolism
- Genetics, Bioinformatics, and Biomedical Research
- Biochemical and Molecular Research
- Hematopoietic Stem Cell Transplantation
Sun Yat-sen University
2008-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2020-2024
University of Hong Kong
2013-2020
Queen Mary Hospital
2018
Chinese University of Hong Kong
2013-2017
Most of the current methods for programmable RNA drug therapies are unsuitable clinic due to low uptake efficiency and high cytotoxicity. Extracellular vesicles (EVs) could solve these problems because they represent a natural mode intercellular communication. However, cellular sources EV production limited in availability safety terms horizontal gene transfer. One potentially ideal source be human red blood cells (RBCs). Group O-RBCs can used as universal donors large-scale since readily...
Copper is an essential trace element for the human body, and its requirement optimistic immune functions has been recognized decades. How copper involved in innate pathway, however, remains to be clarified. Here, we report that serves as a signal molecule regulate kinase activity of alpha-kinase 1 (ALPK1), cytosolic pattern-recognition receptor (PRR), therefore promotes host cell defense against bacterial infection. We show response infection, cells actively accumulate cytosol, accumulated...
An in vitro drug screening using primary AML samples identified homoharringtonine (omacetaxine mepesuccinate) as an effective adjunct for treatment of FLT3-ITD AML.
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and myelosuppression attributed to a 'synthetic lethal toxicity' arising from simultaneous inhibition of KIT. We report novel chemical strategy selective while avoiding KIT the staurosporine analog, Star 27. 27 maintains potency against proliferation assays...
Due to drug resistance, the clinical response cisplatin (CDDP) from patients with liver cancer is unsatisfactory.The alleviation or overcoming of CDDP resistance an urgent problem be solved in clinics.Tumor cells rapidly change signal pathways mediate under exposure.Here, multiple phosphor-kinase assays were performed and c-Jun N-terminal kinase (JNK) was activated treated CDDP.The high activity JNK promotes poor progression mediates cancer, leading a prognosis cancer.Mechanistically, highly...
Infectious spleen and kidney necrosis virus (ISKNV) causes a pandemic serious disease in fish. Infection by ISKNV epidermal lesions, which petechial hemorrhages abdominal edema are prominent features. ORF48R contains domain similar to that of the platelet-derived growth factor vascular endothelial (VEGF) families proteins. showed higher similarity VEGFs encoded Megalocytivirus Parapoxvirus than those fish mammals. We used zebrafish as model constructed recombinant plasmid containing DNA...
Infectious spleen and kidney necrosis virus (ISKNV) is the type species of Megalocytivirus genus Iridoviridae family. It causes a serious potentially pandemic disease in wild cultured fishes. ISKNV infection induces evident apoptosis mandarin fish (Siniperca chuatsi) zebrafish (Danio renio). However, mechanism still unknown. After genome-wide bioinformatics analysis ISKNV-encoded proteins, open reading frame 111L (ORF111L) shows high similarity to tumour factor receptor-associated (TRAF)...
Purpose: In this study, we aimed to investigate the effect of follistatin (FST) on hepatic steatosis in NAFLD and underlying mechanism, which has rarely been reported before. Methods: Liver samples from patients normal liver (from donors) were collected FST expression humans. Additionally, human cells (LO2) treated with free fatty acid (FFA) induce lipid accumulation. Furthermore, lentivirus overexpression or knockdown vectors used generate stable cell lines, subsequently FFA rapamycin....
Article5 March 2020Open Access Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia Bai-Liang He Division of Hematology, Department Medicine, Li Ka Shing Faculty The University Hong Kong, Kong SAR, China Guangdong Provincial Key Laboratory Biomedical Imaging, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Province, Search for more papers by this author Ning Yang Cheuk Him Man Nelson Ka-Lam Ng Chae-Yin Cher Ho-Ching Leung Leo Lai-Hok Kan Bowie...
Infectious spleen and kidney necrosis virus (ISKNV) is the type species of Megalocytivirus genus, Iridoviridae family, causing a severe systemic disease with high mortality in mandarin fish (Siniperca chuatsi) China Southeast Asia. At present, pathogenesis ISKNV infection still not fully understood. Based on genome-wide bioinformatics analysis ISKNV-encoded proteins, we found that open reading frame 119L (ORF119L) predicted to encode three-ankyrin-repeat (3ANK)-domain-containing protein,...
ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the factor family. It expressed in hematopoietic tissue during embryonic development, but its function was unknown. Zebrafish arl4aa preferentially ventral wall dorsal aorta (VDA) at 24 and 36 hpf caudal 48 hpf. Morpholino knockdown transcription activator-like effector nuclease (TALEN) knockout significantly reduced expression genes associated with definitive stem cells (HSCs). Golgi complex integrity VDA disrupted as shown by...
Acute myeloid leukemia (AML) is the most common type of acute in adults. Internal tandem duplication FMS-like tyrosine kinase 3 (FLT3-ITD) mutations occur about 25%-30% AML cases and are associated with adverse prognosis. Recent advances indicate that M2-like leukemia-associated macrophages (M2-LAM) highly infiltrated bone marrow FLT3-ITD+ patients; however, underlying mechanisms therapeutic implications still elusive. Herein, we reveal conditioned medium from MOLM-13 cells polarized M2-LAM...